抗TSLP Receptor抗体(Anti-TSLP Receptor, Goat-Poly, PE antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Mouse
Label	Phycoerythrin
Immunogen	Mouse myeloma cell line NS0-derived recombinant mouse TSLP RAla20-Leu233Accession # BAA92159
Source	Polyclonal Goat IgG
Purification	Antigen Affinity-purified
Specificity	Detects mouse TSLP R in direct ELISAs and Western blots.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry
	Detection of TSLP R in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Goat Anti-Mouse TSLP R PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB5461P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Background

TSLP R

background_content

Background: TSLP R TSLP R, also named Delta (1) and CRLM-2 (2) (cytokine receptor-like module-2), was originally cloned as a novel type 1 cytokine receptor with similarity to the common gamma chain. It was subsequently identified to be a subunit of the cellular receptor for the IL-7-like cytokine TSLP and termed TSLP R (3). The TSLP R cDNA encodes a 359 amino acid (aa) residue type 1 membrane protein with a 24 aa residue signal peptide, a 206 aa residue extracellular domain that showed 24% sequence identity with the mouse common gamma receptor, a 23 aa residue transmembrane domain, and a 106 aa residue cytoplasmic domain. The cytoplasmic domain of TSLP R contains a membrane-proximal box1 motif which is known to be important for association with JAKs. An alternatively spliced mRNA variant encoding a soluble TSLP R has also been reported (2). TSLP R expression is ubiquitous in the immune and hematopoietic cells, but is up-regulated in Th2-skewed cells. Cells expressing TSLP R alone bind TSLP with low affinity. Co-expression of TSLP R and IL-7 R alpha is required for high-affinity TSLP binding and signal transduction (3, 4).

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Citations

1. Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells
   Authors: A Onodera, M Kiuchi, K Kokubo, M Kato, T Ogino, S Horiuchi, U Kanai, K Hirahara, T Nakayama
   J. Immunol., 2017;0(0):.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


2. Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection.
   Authors: Wiesner, Darin L, Specht, Charles, Lee, Chrono K, Smith, Kyle D, Mukaremera, Liliane, Lee, S Thera, Lee, Chun G, Elias, Jack A, Nielsen, Judith N, Boulware, David R, Bohjanen, Paul R, Jenkins, Marc K, Levitz, Stuart M, Nielsen, Kirsten
   PLoS Pathog, 2015;11(3):e1004701.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


3. IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin.
   Authors: Oh MH, Oh SY, Yu J
   J. Immunol., 2011;186(12):7232-42.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


4. Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9⁺ and IL-13⁺ type 2 innate lymphoid cell subpopulations.
   Authors: Verma M, Liu S, Michalec L, Sripada A, Gorska M, Alam R
   J Allergy Clin Immunol, 0;0(0):.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow

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