抗Human/Rat CCR4 Phycoerythrin抗体(Anti-Human/Rat CCR4 Phycoerythrin antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human, Rat
Label	Phycoerythrin
Immunogen	Human CCR4 transfectantsMet1-Leu360Accession # P51679
Source	Monoclonal Mouse IgG2B Clone # 205410
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Stains human CCR4-transfected cell lines but not the corresponding parent cell lines. Also detects human CCR4 on human PBLs and platelets and rat CCR4 on rat splenocytes.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry
	Detection of CCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD3 epsilon APC‑conjugated Monoclonal Antibody (Catalog # FAB100A) and either (A) Mouse Anti-Human/Rat CCR4 PE‑conjugated Monoclonal Antibody (Catalog # FAB1567P) or (B) Mouse IgG2B Phycoerythrin Isotype Control (Catalog # IC0041P). View our protocol for Staining Membrane-associated Proteins.
Flow Cytometry
	Detection of CCR4 in Rat Peripheral Blood Cells by Flow Cytometry. Rat peripheral blood cells were stained with Mouse Anti-Human/Rat CCR4 PE‑conjugated Monoclonal Antibody (Catalog # FAB1567P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Entrez Gene IDs	1233 (Human); 12773 (Mouse); 171054 (Rat)
Background	CCR4
background_content	Background: CCR4 CCR4 is a G protein-linked seven transmembrane domain chemokine receptor that binds the chemokines CCL17/TARC and CCL22/MDC. Current evidence suggests that CCR4 expression is associated with Th-2 type T cells and with platelets. CCR4 expression has also been reported in mature dendritic cells.

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Citations

1. Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity
   Authors: Lee Faulkner
   Toxicol. Sci, 2016;154(2):416-429.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma
   Authors: Grégory Seumois
   J Immunol, 2016;0(0):.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


3. Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin
   Authors: Zhirui Wang
   Vet. Immunol. Immunopathol., 2016;182(0):150-158.
   Species: Porcine
   Sample Type: Whole Blood
   Application: Flow


4. Aberrant CCR4 expression is involved in tumor invasion of lymph node-negative human gastric cancer.
   Authors: Yang, Yongmei, Du, Lutao, Yang, Xiaoyun, Qu, Ailin, Zhang, Xin, Zhou, Chengjun, Wang, Chuanxin
   PLoS ONE, 2015;10(3):e0120059.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


5. Phase I clinical trial of multiple-peptide vaccination for patients with advanced biliary tract cancer.
   Authors: Aruga, Atsushi, Takeshita, Nobuhiro, Kotera, Yoshihit, Okuyama, Ryuji, Matsushita, Norimasa, Ohta, Takehiro, Takeda, Kazuyosh, Yamamoto, Masakazu
   J Transl Med, 2014;12(0):61.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


6. Chemokines as novel and versatile reagents for flow cytometry and cell sorting.
   Authors: Le Brocq M, Fraser A, Cotton G, Woznica K, McCulloch C, Hewit K, McKimmie C, Nibbs R, Campbell J, Graham G
   J Immunol, 2014;192(12):6120-30.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


7. IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation.
   Authors: Morandi, Fabio, Di Carlo, Emma, Ferrone, Soldano, Petretto, Andrea, Pistoia, Vito, Airoldi, Irma
   J Immunol, 2014;192(6):2634-42.
   


8. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
   Authors: Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH
   J. Immunol., 2010;184(6):2886-98.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


9. CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses.
   Authors: Carbone T, Nasorri F, Pennino D
   J. Immunol., 2010;184(2):1102-10.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


10. The Lupane-type Triterpene 30-Oxo-calenduladiol Is a CCR5 Antagonist with Anti-HIV-1 and Anti-chemotactic Activities.
    Authors: Barroso-Gonzalez J, El Jaber-Vazdekis N, Garcia-Exposito L, Machado JD, Zarate R, Ravelo AG, Estevez-Braun A, Valenzuela-Fernandez A
    J. Biol. Chem., 2009;284(24):16609-20.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow

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