抗CD68抗体(Anti-CD68, Mouse-Mono antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Unconjugated
Immunogen	Mouse myeloma cell line NS0-derived recombinant human CD68/SR‑D1Asn22-Ile320Accession # AAB25811
Source	Monoclonal Mouse IgG2B Clone # 298807
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human CD68/SR‑D1 in direct ELISAs.

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Applications and Data

	Recommended Concentration	Sample
CyTOF-ready	Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
Immunocytochemistry	8-25 µg/mL	See below
Intracellular Staining by Flow Cytometry	2.5 µg/106 cells	U937 human histiocytic lymphoma cell line fixed with paraformaldehyde and permeabilized with methanol

Immunocytochemistry

CD68/SR-D1 in Human PBMCs. CD68/SR-D1 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) stimulated with PHA using Human CD68/SR-D1 Monoclonal Antibody (Catalog # MAB20401) at 25 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to the plasma membrane and cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

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Related Product & Information

Entrez Gene IDs	968 (Human)
Background	CD68/SR-D1
background_content	Background: CD68/SR-D1 CD68, also called Scavenger Receptor D1 (SR-D1), is a type I transmembrane glycoprotein that belongs to the LAMP family of molecules. CD68 is expressed on monocytes and macrophages and serves as a scavenger receptor for oxidized LDL.

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Citations

1. Autophagy Is an Innate Mechanism Associated with Leprosy Polarization
   Authors: BJ Silva, MG Barbosa, PR Andrade, H Ferreira, JA Nery, S C“rte-Real, GM da Silva, PS Rosa, M Fabri, EN Sarno, RO Pinheiro
   PLoS Pathog, 2017;13(1):e1006103.
   Species: Human
   Sample Type: Whole Cells
   Application: ICC


2. Association between PON1 rs662 polymorphism and coronary artery disease.
   Authors: Liu T, Zhang X, Zhang J, Liang Z, Cai W, Huang M, Yan C, Zhu Z, Han Y
   Eur J Clin Nutr, 2014;68(9):1029-35.
   Species: Human
   Sample Type: Whole Tissue
   Application: IHC - paraffin


3. Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy.
   Authors: Lu TC, Wang ZH, Feng X, Chuang PY, Fang W, Shen Y, Levy DE, Xiong H, Chen N, He JC
   Kidney Int., 2009;76(1):63-71.
   Species: Mouse
   Sample Type: Whole Tissue
   Application: IHC Paraffin-embedded


4. Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema.
   Authors: Shan M, Cheng HF, Song LZ
   Sci Transl Med, 2009;1(4):4ra10.
   Species: Human
   Sample Type: Whole Cells
   Application: ICC


5. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity.
   Authors: Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR
   Diabetes, 2007;56(1):16-23.
   Species: Mouse
   Sample Type: Whole Cells
   Application: ICC


6. Human periprosthetic tissues implanted in severe combined immunodeficient mice respond to gene transfer of a cytokine inhibitor.
   Authors: Yang SY, Nasser S, Markel DC, Robbins PD, Wooley PH
   J Bone Joint Surg Am, 2005;87(5):1088-97.
   Species: Human
   Sample Type: Whole Tissue
   Application: IHC

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