抗Mouse ACE-2抗体(Anti-Mouse ACE-2 antibody)
掲載日情報：2019/10/21 現在Webページ番号：32852
Mouse ACE-2に対する抗体(Anti-Mouse ACE-2 )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2024年04月26日 19時15分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-Mouse ACE-2 Affinity Purified Polyclonal Ab (100 UG) |
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Anti-Mouse ACE-2 Affinity Purified Polyclonal Ab |
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[在庫・価格 ：2024年04月26日 19時15分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-Mouse ACE-2 Affinity Purified Polyclonal Ab (100 UG)
文献数： 7
- 商品コード：AF3437
- メーカー：RSD
- 包装：100μg
- 価格：¥106,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
別名：ACE2 Genbank No： 59272 Protein Accession No： Q8R0I0 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | Mouse | 免疫動物 | Goat | ||||
| 交差性 | Mouse | 適用 | ELISA,FCM,IHC,IP,Simple Western,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Polyclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 |
免疫染色システム ImmPRESS® Reagent Anti-Goat IgG 肺オルガノイド培養関連製品（Products for Lung Organoids） |
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| 関連記事 | |||||||
Anti-Mouse ACE-2 Affinity Purified Polyclonal Ab
文献数： 3
- 商品コード：AF3437-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
※受注発注品。形状：溶液または凍結乾燥 別名：ACE2 Genbank No： 59272 Protein Accession No： Q8R0I0 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Goat | |||||
| 交差性 | Mouse | 適用 | ELISA,FCM,IHC,IP,Simple Western,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Polyclonal | フォーマット | |||||
| 掲載カタログ |
|
||||||
| 製品記事 |
免疫染色システム ImmPRESS® Reagent Anti-Goat IgG 肺オルガノイド培養関連製品（Products for Lung Organoids） |
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| 関連記事 | |||||||
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Product Details
| Species Reactivity | Mouse |
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| Label | Unconjugated |
| Immunogen | Chinese hamster ovary cell line CHO-derived recombinant mouse ACE-2Gln18-Thr740Accession # Q8R0I0 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects mouse ACE-2 in direct ELISAs and Western blots. In Western blots, approximately 40% cross-reactivity with recombinant human ACE‑2 is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.25 µg/mL | See below |
| Simple Western | 2.5 µg/mL | See below |
| Immunohistochemistry | 5-15 µg/mL | See below |
| Immunoprecipitation | 25 µg/mL | Conditioned cell culture medium spiked with Recombinant Mouse ACE‑2 (Catalog # 3437‑ZN), see our available Western blot detection antibodies |
| Western Blot | |
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 | Detection of Mouse ACE‑2 by Western Blot. Western blot shows lysates of mouse kidney tissue. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse ACE‑2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3437) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for ACE‑2 at approximately 95 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1. |
| Immunohistochemistry | |
 | ACE‑2 in Mouse Kidney. ACE‑2 was detected in perfusion fixed frozen sections of mouse kidney using 15 µg/mL Goat Anti-Mouse ACE‑2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3437) overnight at 4 °C. Tissue was stained (red) and counterstained (green). View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections. |
| Immunohistochemistry | |
 | ACE‑2 in Mouse Kidney. ACE‑2 was detected in perfusion fixed frozen sections of mouse kidney using Goat Anti-Mouse ACE‑2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3437) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections. |
| Simple Western | |
 | Detection of Mouse ACE‑2 by Simple WesternTM. Simple Western lane view shows lysates of mouse kidney tissue, loaded at 0.2 mg/mL. A specific band was detected for ACE‑2 at approximately 141 kDa (as indicated) using 2.5 µg/mL of Goat Anti-Mouse ACE‑2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3437) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system. |
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Related Product & Information
| Background | ACE-2 |
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| background_content | Background: ACE-2 ACE-2, also called ACEH (ACE homologue), is an integral membrane protein and a zinc metalloprotease of the ACE family that also includes somatic and germinal ACE (1). Mouse ACE-2 has about 40% amino acid identity to the N- and C-terminal domains of mouse somatic ACE. The predicted mouse ACE-2 protein sequence consists of 798 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 cleaves angiotensins I and II as a carboxypeptidase. ACE-2 mRNA is found at high levels in testis, kidney and heart and at moderate levels in colon, small intestine and ovary. Classical ACE inhibitors such as captopril and lisinopril do not inhibit ACE-2 activity. Novel peptide inhibitors of ACE-2 do not inhibit ACE activity (2). Genetic data from Drosophila, mice and rats show that ACE-2 is an essential regulator of heart function in vivo (3). In addition, ACE-2 is a key SARS-CoV Spike protein receptor in vivo and has a critical function in acute lung injury (4, 5). |
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
- Expression and regulation of the neutral amino acid transporter B0AT1 in rat small intestine
Authors: J Jando, SMR Camargo, B Herzog, F Verrey
PLoS ONE, 2017;12(9):e0184845.
Species: Rat
Sample Type: Cell Lysates
Application: WB - ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.
Authors: Hashimoto T, Perlot T, Rehman A
Nature, 2012;487(7408):477-81.
Species: Mouse
Sample Type: Tissue Homogenates
Application: WB - Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3.
Authors: Singer D, Camargo SM, Huggel K, Romeo E, Danilczyk U, Kuba K, Chesnov S, Caron MG, Penninger JM, Verrey F
J. Biol. Chem., 2009;284(30):19953-60.
Species: Mouse
Sample Type: Cell Lysates
Application: WB
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