抗Human Siglec-6抗体(Anti-Human Siglec-6 antibody)
掲載日情報:2019/10/21 現在Webページ番号:32768
Human Siglec-6に対する抗体(Anti-Human Siglec-6 )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2025年04月26日 20時55分現在]
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Anti-Human Siglec-6 Affinity Purified Polyclonal Ab (100 UG) |
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Anti-Human Siglec-6/CD327 Affinity Purified Polyclonal Ab |
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[在庫・価格 :2025年04月26日 20時55分現在]
Anti-Human Siglec-6 Affinity Purified Polyclonal Ab (100 UG)
文献数: 1
- 商品コード:AF2859
- メーカー:RSD
- 包装:100μg
- 価格:¥100,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 別名:CD327 Genbank No: 946 Protein Accession No: NP_942142 |
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別包装品 | 別包装品あり | ||||||
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保存条件 | -20℃ | 法規備考 | |||||
抗原種 | Human | 免疫動物 | Sheep | ||||
交差性 | Human | 適用 | ELISA,Western Blot | ||||
標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Polyclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | Myeloid-derived Suppressor Cell Marker |
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関連記事 |
Anti-Human Siglec-6/CD327 Affinity Purified Polyclonal Ab
文献数: 0
- 商品コード:AF2859-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥30,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
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Product Details
Species Reactivity | Human |
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Label | Unconjugated |
Immunogen | Chinese hamster ovary cell line CHO-derived recombinant human Siglec‑6/CD327Gln27-Val331Accession # NP_942142 |
Source | Polyclonal Sheep IgG |
Purification | Antigen Affinity-purified |
Specificity | Detects human Siglec‑6/CD327 in direct ELISAs and Western blots. In Western blots, approximately 20% cross‑reactivity with recombinant human (rh) Siglec-3, rhSiglec-5 and rhSiglec-9 is observed, approximately 5% cross‑reactivity with rhSiglec-10 is observed, and less than 1% cross‑reactivity with rhSiglec-2, rhSiglec-7, and rhSiglec-11 is observed. |
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Applications and Data
Recommended Concentration | Sample | |
Western Blot | 0.1 µg/mL | Recombinant Human Siglec‑6 Fc Chimera (Catalog # 2859-SL) |
ELISA | This antibody functions as an ELISA detection antibody when paired with Mouse Anti-Human Siglec‑6/CD327 Monoclonal Antibody (Catalog # MAB28591). This product is intended for assay development on various assay platforms requiring antibody pairs. We recommend the Human Siglec-6/CD327 DuoSet ELISA Kit (Catalog # DY2859-05) for convenient development of a sandwich ELISA. |
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Related Product & Information
Background | Siglec-6/CD327 |
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background_content | Background: Siglec-6/CD327 Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins that belong to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (1‑4). Eleven human Siglecs (Siglec-1 through 11) have been cloned and characterized. Within these eleven, there are at least two groups, one of which is termed the CD33-related group. CD33-related Siglecs include CD33/Siglec-3 and Siglec-5 through 11 (1, 3). To date, no Siglec has been shown to recognize any cell surface ligand other than sialic acid. This suggests that interactions with glycans containing this carbohydrate are important in mediating the biological functions of Siglecs. The cDNA of human Siglec-6 (also known as OB-BP1 and CD33L), encodes a putative 442 amino acid (aa) protein that contains a 15 aa signal peptide, a 321 aa extracellular region, a 21 aa transmembrane region (TM), and an 85 aa cytoplasmic tail (5, 6). The extracellular region contains one N-terminal V-type Ig-like domain followed by two Ig-like C2-type domains. The cytoplasmic domain has one immunoreceptor tyrosine-based inhibition motif (ITIM). At least three additional isoforms exist, all of which encode an additional 11 aa’s at the N-terminus, likely due to the utilization of an alternate start site. Two of the three isoforms also show splicing. One isoform shows a 16 aa in-frame deletion in the second C2-like domain, while the other shows a deletion of the TM and cytoplasmic region, thus potentially generating a soluble form (6‑9). Siglec-6 is found on B cells and in placenta, and would seem to have a restricted specificity for the sialyl Tn antigen (6, 10). |
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Citations
- Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway.
Authors: Lam KK, Chiu PC, Lee CL
J. Biol. Chem., 2011;286(43):37118-27.
Species: Human
Sample Type: Protein
Application: WB
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