抗MAdCAM-1抗体(Anti-MAdCAM-1, Rat-Mono antibody)
掲載日情報：2021/01/28 現在Webページ番号：32223
MAdCAM-1に対する抗体(Anti-MAdCAM-1, Rat-Mono )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
価格
[在庫・価格 ：2025年07月02日 15時35分現在]
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Anti-MAdCAM-1, Rat-Mono(200530) |
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Anti-Mouse MAdCAM-1 MAb (Clone 200530) |
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[在庫・価格 ：2025年07月02日 15時35分現在]
Anti-MAdCAM-1, Rat-Mono(200530)
文献数： 0
- 商品コード：MAB9931
- メーカー：RSD
- 包装：500μg
- 価格：¥93,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Mouse MAdCAM-1 サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAF993，スタンダードとして#993-MC-050を用いる。 別名：hMAdCAM-1 クローン：200530 Genbank No： 8174 Protein Accession No： NP_038619 |
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| 保存条件 | 法規備考 | ||||||
| 抗原種 | Mouse | 免疫動物 | Rat | ||||
| 交差性 | Mouse | 適用 | ELISA | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
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| 製品記事 | |||||||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Mouse MAdCAM-1 MAb (Clone 200530)
文献数： 0
- 商品コード：MAB9931-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥25,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：hMAdCAM-1 クローン：200530 Genbank No： 8174 Protein Accession No： NP_038619 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | 法規備考 | ||||||
| 抗原種 | 免疫動物 | Rat | |||||
| 交差性 | Mouse | 適用 | ELISA | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | 使いっきり抗体 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Mouse |
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| Label | Unconjugated |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse MAdCAM-1Gln22-Thr365 (predicted)Accession # NP_038619 |
| Source | Monoclonal Rat IgG1 Clone # 200530 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects human and mouse MAdCAM‑1 in ELISAs. |
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Applications and Data
| Recommended Concentration | Sample | |
| Mouse MAdCAM-1 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Mouse MAdCAM‑1 Antibody (Catalog #MAB9931 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse MAdCAM‑1 Biotinylated Antibody (Catalog #BAF993 ) |
| ELISA Standard | Recombinant Mouse MAdCAM-1 Fc Chimera Protein, CF (Catalog #993-MC ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: MAdCAM-1 | Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is an immunoglobulin (Ig) cell adhesion molecule family member. In addition to Ig domains, it contains a mucin-like domain and a membrane proximal domain with similarity to IgA. MAdCAM-1 is involved in lymphocyte homing to mucosal sites and is expressed on high endothelial venules (HEV) of both mesenteric lymph nodes and Peyer’s patches. It has also been found to be expressed on sinus-lining cells of the spleen. The integrin, alpha 4 beta 7, has been shown to function as the MAdCAM-1 receptor. The Ig domains of MAdCAM-1 have been found to be critical to alpha 4 beta 7 binding. The mucin domain has been shown to have activity in L-Selectin binding. MAdCAM-1 expression has been demonstrated to be up-regulated by TNF-alpha and IL-1 beta. MAdCAM-1 appears to play a role in inflammatory bowel disease (IBD) as its expression is highly up-regulated in IBD and most likely serves to recruit alpha 4 beta 7-expressing lymphocytes to the region. In vivo studies involving nonobese diabetic (NOD) mice have also suggested that MAdCAM-1/ alpha 4 beta 7 interaction plays a role in diabetes development in this model. Mouse MAdCAM-1 is a 405 amino acid (aa) residue protein with a 21 aa signal sequence, a 344 aa extracellular domain, a 20 aa transmembrane domain and a 20 aa cytoplasmic domain. |
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References
| Briskin, M.J. et al. (1993) Nature 363:461. | |
| Yang, X.D. et al. (1997) Diabetes 46:1542. | |
| Sampaio, S.O. et al. (1995) J. Immunol. 155:2477. | |
| Kraal, G. et al. (1995) Am. J. Pathol. 147:763. | |
| Berg, E.L. et al. (1993) Nature 366:695. | |
| Takeuchi, M. and V.R. Baichwal (1995) Proc. Natl. Acad. Sci. USA 92:3561. | |
| Long Name: | Mucosal Addressin Cell Adhesion Molecule 1 |
| Entrez Gene IDs: | 8174 (Human); 17123 (Mouse) |
| Alternate Names: | hMAdCAM-1; MACAM1; MAdCAM1; MAdCAM-1; mucosal addressin cell adhesion molecule 1; mucosal addressin cell adhesion molecule-1; mucosal vascular addressin cell adhesion molecule 1 |
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Related Research Areas
| Adhesion Molecules in Angiogenesis |
| Immunoglobulin Superfamily CAMs |
| Regulatory T Cells (Tregs) |
追加しました。
Related Product & Information
| Background | MAdCAM-1 |
|---|---|
| background_content | Background: MAdCAM-1 Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is an immunoglobulin (Ig) cell adhesion molecule family member. In addition to Ig domains, it contains a mucin-like domain and a membrane proximal domain with similarity to IgA. MAdCAM-1 is involved in lymphocyte homing to mucosal sites and is expressed on high endothelial venules (HEV) of both mesenteric lymph nodes and Peyer’s patches. It has also been found to be expressed on sinus-lining cells of the spleen. The integrin, alpha 4 beta 7, has been shown to function as the MAdCAM-1 receptor. The Ig domains of MAdCAM-1 have been found to be critical to alpha 4 beta 7 binding. The mucin domain has been shown to have activity in L-Selectin binding. MAdCAM-1 expression has been demonstrated to be up-regulated by TNF-alpha and IL-1 beta. MAdCAM-1 appears to play a role in inflammatory bowel disease (IBD) as its expression is highly up-regulated in IBD and most likely serves to recruit alpha 4 beta 7-expressing lymphocytes to the region. In vivo studies involving nonobese diabetic (NOD) mice have also suggested that MAdCAM-1/ alpha 4 beta 7 interaction plays a role in diabetes development in this model. Mouse MAdCAM-1 is a 405 amino acid (aa) residue protein with a 21 aa signal sequence, a 344 aa extracellular domain, a 20 aa transmembrane domain and a 20 aa cytoplasmic domain. |
追加しました。
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