抗FcγRIIB/C抗体(Anti-FcγRIIB/C, Mouse-Mono, Biotin antibody)

• 価格
• Product Details
• Applications and Data
• Related Research Areas
• Related Product & Information

価格

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Product Details

Species Reactivity	Human
Label	Biotin
Immunogen	Mouse myeloma cell line NS0-derived recombinant human Fc gamma RIIB/CAla46-Pro217Accession # P31994
Source	Monoclonal Mouse IgG2A Clone # 190703
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human Fc gamma RIIB/C in ELISAs. In ELISAs, this antibody shows approximately 40% cross-reactivity with recombinant human (rh) Fc gamma  RIIA and no cross‑reactivity with rhFc gamma RI, rmFc gamma RI, rmFc gamma RIIB, rhFc gamma RIIIB, rmFc gamma RIII, or rmFcrl3/CD16-2.

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Applications and Data

	Recommended Concentration	Sample
Human Fc gamma RIIB/CD32b Sandwich Immunoassay	Reagent
ELISA Capture (Matched Antibody Pair)	2-8 µg/mL	Human Fc gamma  RIIB/C (CD32b/c) Antibody (Catalog #MAB18751 )
ELISA Detection (Matched Antibody Pair)	0.5-2.0 µg/mL	Human Fc gamma  RIIB/C (CD32b/c) Biotinylated Antibody (Catalog #BAM1875 )
ELISA Standard		Recombinant Human Fc gamma RIIB/C (CD32b/c) Protein, CF (Catalog #1875-CD )
Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website.		Preparation and Storage
Reconstitution	Reconstitute at 0.5 mg/mL in sterile PBS.	Reconstitution Buffer Available
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Fc gamma RIIB/C (CD32b/c)	Fc gamma RII, also known as CD32, is a group of three closely related proteins (Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIC) that share greater than 94% amino acid identity in their extracellular domains. They function as transmembrane receptors for the Fc portion of IgG molecules. These proteins are expressed by various hematopoietic cells including monocytes, macrophages, neutrophils, NK, T and B cells. The Fc gamma RII proteins are involved in phagocytosis of immune complexes and modulation of antibody production by B cells.
Long Name:	Fc gamma Receptor IIB/C
Entrez Gene IDs:	2213 (Human); 14130 (Mouse)
Alternate Names:	Fc gamma RIIB/C (CD32b/c)

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Related Research Areas

B Cell Activation

Dendritic Cell Pathogen Recognition/Uptake

Fc Receptors

Granulocyte Markers

ITIM/ITAM Immunoreceptors and Related Molecules

Myeloid-derived Suppressor Cells (MDSC)

Uptake of Amyloid beta by Glia Cells

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Related Product & Information

Background

Fc gamma RIIB/C (CD32b/c)

background_content

Background: Fc gamma RIIB/C (CD32b/c) Fc gamma RII, also known as CD32, is a group of three closely related proteins (Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIC) that share greater than 94% amino acid identity in their extracellular domains. They function as transmembrane receptors for the Fc portion of IgG molecules. These proteins are expressed by various hematopoietic cells including monocytes, macrophages, neutrophils, NK, T and B cells. The Fc gamma RII proteins are involved in phagocytosis of immune complexes and modulation of antibody production by B cells.

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