抗Indian Hedgehog抗体(Anti-Indian Hedgehog, N-terminal, Human/Mouse, Goat-Poly antibody)
掲載日情報:2018/11/26 現在Webページ番号:31083
Indian Hedgehogに対する抗体(Anti-Indian Hedgehog, N-terminal, Human/Mouse, Goat-Poly )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2025年05月02日 20時55分現在]
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Anti-Indian Hedgehog, N-terminal, Human/Mouse, Goat-Poly <Anti-Ihh> |
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Anti-Mouse Indian Hedgehog/Ihh N-Term Affinity Purified PAb |
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[在庫・価格 :2025年05月02日 20時55分現在]
Anti-Indian Hedgehog, N-terminal, Human/Mouse, Goat-Poly <Anti-Ihh>
文献数: 4
- 商品コード:AF1705
- メーカー:RSD
- 包装:100μg
- 価格:¥100,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 別名:BDA1 Genbank No: 3549 Protein Accession No: P97812 |
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別包装品 | 別包装品あり | ||||||
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保存条件 | -20℃ | 法規備考 | |||||
抗原種 | Mouse | 免疫動物 | Goat | ||||
交差性 | Mouse | 適用 | IHC,Western Blot | ||||
標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Polyclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | 免疫染色システム ImmPRESS® Reagent Anti-Goat IgG R&D Systems社 Hedgehog Family関連製品 |
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関連記事 |
Anti-Mouse Indian Hedgehog/Ihh N-Term Affinity Purified PAb
文献数: 1
- 商品コード:AF1705-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥30,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | ※受注発注品。形状:溶液または凍結乾燥 別名:BDA1 Genbank No: 3549 Protein Accession No: P97812 |
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別包装品 | 別包装品あり | ||||||
法規制等 | |||||||
保存条件 | -20℃ | 法規備考 | |||||
抗原種 | 免疫動物 | Goat | |||||
交差性 | Mouse | 適用 | IHC,Western Blot | ||||
標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Polyclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | 免疫染色システム ImmPRESS® Reagent Anti-Goat IgG 使いっきり抗体 |
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関連記事 |
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Product Details
Species Reactivity | Mouse |
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Label | Unconjugated |
Immunogen | E. coli-derived recombinant mouse Indian Hedgehog Cys28-Gly202Accession # P97812 |
Source | Polyclonal Goat IgG |
Purification | Antigen Affinity-purified |
Specificity | Detects mouse Indian Hedgehog (Ihh) N-terminal peptide in Western blots. In Western blots, approximately 80% cross-reactivity with recombinant human Shh N-terminal peptide and recombinant mouse (rm) Shh N-terminal peptide is observed, and less than 1% cross‑reactivity with rmIhh C-terminal peptide (amino acids 241-449) is observed. |
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Applications and Data
Recommended Concentration | Sample | |
Western Blot | 0.1 µg/mL | Recombinant Mouse Indian Hedgehog (C28II), N-Terminus |
Immunohistochemistry | 5-15 µg/mL | See below |
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Related Product & Information
Background | Indian Hedgehog/Ihh |
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background_content | Background: Indian Hedgehog/Ihh The hedgehog (hh) gene encoding a secreted protein was originally identified in Drosophila as a segment polarity gene. The vertebrate homologues of Hh comprise several proteins including sonic hedgehog (Shh), Indian hedgehog (Ihh), and Desert hedgehog (Dhh) (1). Hedgehog proteins are important signaling molecules during embryonic development and are highly conserved within and across species (1). Mouse and human Ihh share 100% amino acid (aa) sequence identity in the signaling domain, while mouse Ihh and Shh share 90% aa identity in the N-terminal signaling domain. Ihh mRNA expression is detected in fetal lung, gut, stomach, liver, kidney, pancreas, and strongly in cartilage, in growth regions of the developing bone (2, 3). Ihh, along with parathyroid hormone related protein, regulate the rate of chondrocyte proliferation and differentiation (4). Ihh is also involved in yolk sac vasculogenesis, playing an important role in differentiation of epiblast cells into endothelial and red blood cells (5). Mouse Ihh cDNA encodes a 411 aa polypeptide with a predicted 27 aa signal peptide. This polypeptide is cleaved to generate a 45 kDa precursor protein that undergoes the same post-translation processing as Shh (3). An autocatalytic reaction yields a 19 kDa amino-terminal domain Ihh-N protein that retains all known signaling capabilities, and a 23 kDa carboxy-terminal domain Ihh-C protein (3). Since hydrophobic modifications to Shh, including the substitution of the N-terminal cysteine residue with two hydrophobic isoleucine residues, can also increase its potency (6), a similar modification was made for Ihh. This modified form also shows increased potency in a bioassay measuring induction of alkaline phosphatase. At the cell surface, Hedgehog activity is mediated by a multicomponent receptor complex involving the 12-pass transmembrane protein Patched (Ptc) which binds Hedgehogs with high affinity and Smoothened (Smo), a signaling seven transmembrane G-protein coupled receptor (1). |
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Citations
- Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets
Authors: LK Veistinen, T Mustonen, MR Hasan, M Takatalo, Y Kobayashi, DA Kesper, A Vortkamp, DP Rice
Front Physiol, 2017;8(0):1036.
Species: Mouse
Sample Type: Tissue Homogenates
Application: WB - Inhibition of p38 MAPK signaling in chondrocyte cultures results in enhanced osteogenic differentiation of perichondral cells.
Authors: Stanton LA, Beier F
Exp. Cell Res., 2007;313(1):146-55.
Species: Mouse
Sample Type: Whole Cells
Application: ICC
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