抗Human Mer抗体(Anti-Human Mer antibody)
掲載日情報:2021/01/28 現在Webページ番号:30546
Human Merに対する抗体(Anti-Human Mer )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- Data Examples
- References
- Related Research Areas
- Summary
- Related Product & Information
- Citations
価格
[在庫・価格 :2024年05月04日 00時00分現在]
詳細 | 商品名 |
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Anti-Human Mer MAb (Clone 125518) |
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Anti-Human Mer MAb (Clone 125518) |
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Anti-Human Mer MAb (Clone 125518) |
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[在庫・価格 :2024年05月04日 00時00分現在]
Anti-Human Mer MAb (Clone 125518)
文献数: 0
- 商品コード:MAB8912-100
- メーカー:RSD
- 包装:100μg
- 価格:¥104,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 |
別名:c-Eyk クローン:125518 Genbank No: 10461 Protein Accession No: AAB60430 |
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保存条件 | -20℃ | 法規備考 | |
抗原種 | 免疫動物 | Mouse | |
交差性 | Human | 適用 | ELISA,FCM |
標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
吸収処理 | クラス | IgG | |
クロナリティ | Monoclonal | フォーマット | |
掲載カタログ |
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製品記事 | |||
関連記事 |
R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
Anti-Human Mer MAb (Clone 125518)
文献数: 0
- 商品コード:MAB8912-500
- メーカー:RSD
- 包装:500μg
- 価格:¥232,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 |
マッチドペア:Human Mer サンドイッチELISAの補足用抗体として利用可能,検出用抗体として#BAF891,スタンダードとして#891-MR-100を用いる。 別名:c-Eyk クローン:125518 Genbank No: 10461 Protein Accession No: AAB60430 |
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法規制等 | |||
保存条件 | -20℃ | 法規備考 | |
抗原種 | 免疫動物 | Mouse | |
交差性 | Human | 適用 | ELISA,FCM |
標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
吸収処理 | クラス | IgG | |
クロナリティ | Monoclonal | フォーマット | |
掲載カタログ |
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製品記事 | |||
関連記事 |
R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
Anti-Human Mer MAb (Clone 125518)
文献数: 0
- 商品コード:MAB8912-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥30,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 |
※受注発注品。形状:溶液または凍結乾燥 別名:c-Eyk クローン:125518 Genbank No: 10461 Protein Accession No: AAB60430 |
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法規制等 | |||
保存条件 | -20℃ | 法規備考 | |
抗原種 | 免疫動物 | Mouse | |
交差性 | Human | 適用 | ELISA,FCM |
標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
吸収処理 | クラス | IgG | |
クロナリティ | Monoclonal | フォーマット | |
掲載カタログ |
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製品記事 | |||
関連記事 |
R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
Species Reactivity | Human |
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Label | Unconjugated |
Immunogen | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human MerMet1-Ala499Accession # AAB60430 |
Source | Monoclonal Mouse IgG2B Clone # 125518 |
Purification | Protein A or G purified from hybridoma culture supernatant |
Specificity | Detects human Mer in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) Axl, rhDtk, or recombinant mouse Mer is observed. |
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Applications and Data
Recommended Concentration | Sample | |
Flow Cytometry | 0.25 µg/106 cells | See below |
CyTOF-ready | Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation. | |
Human Mer Sandwich Immunoassay | Reagent | |
ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human Mer Antibody (Catalog #MAB8912 ) |
ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Human Mer Biotinylated Antibody (Catalog #BAF891 ) |
ELISA Standard | Recombinant Human Mer Fc Chimera Protein, CF (Catalog #891-MR ) | |
Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. |
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Data Examples
Flow Cytometry |
click image to view larger | Detection of Mer in HepG2 Human Cell Line by Flow Cytometry.HepG2 human hepatocellular carcinoma cell line was stained with Mouse Anti-Human Mer Monoclonal Antibody (Catalog # MAB8912, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B). |
Flow Cytometry |
click image to view larger | Detection of Mer in U937 Human Cell Line by Flow Cytometry.U937 human histiocytic lymphoma cell line was stained with Mouse Anti-Human Mer Monoclonal Antibody (Catalog # MAB8912, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B). |
Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
Background: Mer | Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Recent studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions. |
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References
Nagata, K. et al. (1996) J. Biol. Chem. 22:30022. | |
Crosier, K.E. and P.S Crosier (1997) Pathology 29:131. | |
Long Name: | Receptor Tyrosine Protein Kinase Mer |
Entrez Gene IDs: | 10461 (Human); 17289 (Mouse) |
Alternate Names: | c-Eyk; c-mer proto-oncogene tyrosine kinase; C-mer; EC 2.7.10; EC 2.7.10.1; MER receptor tyrosine kinase; Mer; MerTK; MGC133349; Receptor tyrosine kinase MerTK; RP38Proto-oncogene c-Mer; STK kinase; tyrosine-protein kinase Mer |
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Related Research Areas
Cancer Biomarkers | ||||||||||
Infectious Diseases | ||||||||||
Mouse Tissue-Resident Macrophage Markers | ||||||||||
Receptor Tyrosine Kinases (RTKs) | ||||||||||
Receptor Tyrosine Kinases (RTKs) in the Akt Pathway | ||||||||||
Receptors in the Jak/STAT Pathway | ||||||||||
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Images | Ratings | Applications | Species | Reviewed By | Date | Details | ||||
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Very Good | Anonymous | 04/26/2017 | ||||||||
Enlarge | Excellent | Functional Assay | Human | Anonymous | 06/07/2016 | Image Details |
Functional Assay: Human Mer Antibody [MAB8912]. |
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Summary
Application | Functional Assay |
Sample Tested | NCI-H1299 |
Species | Human |
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Related Product & Information
Background | Mer |
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background_content | Background: Mer Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Recent studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions. |
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Citations
- CD14(+)CD15(-)HLA-DR(-) myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure
Authors: C Bernsmeier, E Triantafyl, R Brenig, FJ Lebosse, A Singanayag, VC Patel, OT Pop, W Khamri, R Nathwani, R Tidswell, CJ Weston, DH Adams, MR Thursz, JA Wendon, CG Antoniades
Gut, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Flow - The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles
Authors: KE Happonen, S Tran, M Mörgelin, R Prince, S Calzavarin, A Angelillo-, B Dahlbäck
J. Biol. Chem., 2016;291(20):10586-601.
Species: Human
Sample Type: Cell Lysates
Application: WB - Identification of Axl as a downstream effector of TGF-beta1 during Langerhans cell differentiation and epidermal homeostasis.
J. Exp. Med., 2012;209(11):2033-47.
Species: Human
Sample Type: Whole Cells
Application: Flow - Expression of the vitamin K-dependent proteins GAS6 and protein S and the TAM receptor tyrosine kinases in human atherosclerotic carotid plaques.
Authors: Hurtado B, Munoz X, Recarte-Pelz P, Garcia N, Luque A, Krupinski J, Sala N, Garcia de Frutos P
Thromb. Haemost., 2011;105(5):873-82.
Species: Human
Sample Type: Tissue Homogenates
Application: WB - GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche.
Authors: Shiozawa Y, Pedersen EA, Taichman RS
Exp. Hematol., 2010;38(2):132-40.
Species: Human
Sample Type: Whole Cells
Application: Flow
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