抗Human CD4 Allophycocyanin抗体(Anti-Human CD4 Allophycocyanin antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Allophycocyanin
Immunogen	Recombinant Human CD4.Extracellular DomainAccession # P01730
Source	Monoclonal Mouse IgG2A Clone # 11830
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human CD4 in direct ELISAs.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry

Detection of CD4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD3 epsilon PE‑conjugated Monoclonal Antibody (Catalog # FAB100P) and either (A) Mouse Anti-Human CD4 APC‑conjugated Monoclonal Antibody (Catalog # FAB3791A) or (B) Mouse IgG2A Allophycocyanin Isotype Control (Catalog # IC003A). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Entrez Gene IDs	920 (Human); 12504 (Mouse); 24932 (Rat); 403931 (Canine); 493775 (Feline)
Background	CD4
background_content	Background: CD4 CD4 is a type I membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed predominantly on thymocytes and a subset of mature T lymphocytes. CD4 functions in collaboration with the T cell receptor in the recognition of peptide antigens that are presented by class II major histocompatibility complexes. CD4 also has been shown to be a coreceptor of HIV entry and specifically binds gp120, the external envelope glycoprotein of HIV.

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Citations

1. IL-4 primes the dynamics of breast cancer progression via DUSP4 inhibition
   Authors: M Gaggianesi, A Turdo, A Chinnici, E Lipari, T Apuzzo, A Benfante, I Sperduti, S Di Franco, S Meraviglia, E Lo Presti, F Dieli, V Caputo, G Militello, S Vieni, G Stassi, M Todaro
   Cancer Res., 2017;0(0):.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. Increased numbers of CD5+CD19+CD1dhighIL-10+ Bregs, CD4+Foxp3+ Tregs, CD4+CXCR5+Foxp3+ follicular regulatory T (TFR) cells in CHB or CHC patients.
   Authors: Wang L, Qiu J, Yu L, Hu X, Zhao P, Jiang Y
   J Transl Med, 2014;12(0):251.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


3. CD8(+) tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma.
   Authors: Fujii H, Arakawa A, Utsumi D, Sumiyoshi S, Yamamoto Y, Kitoh A, Ono M, Matsumura Y, Kato M, Konishi K, Shiga T, Sano S, Sakaguchi S, Miyagawa-Hayashino A, Takahashi K, Uezato H, Miyachi Y, Tanioka M
   Int J Cancer, 2014;134(10):2393-402.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


4. The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4.
   Authors: van Wilgenburg, Bonnie, Moore, Michael, James, William, Cowley, Sally A
   PLoS ONE, 2014;9(1):e86071.
   


5. VEGFR2 is selectively expressed by FOXP3high CD4+ Treg.
   Authors: Suzuki H, Onishi H, Wada J, Yamasaki A, Tanaka H, Nakano K, Morisaki T, Katano M
   Eur. J. Immunol., 2010;40(1):197-203.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


6. The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors.
   Authors: Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS
   J. Immunol., 2006;177(7):4488-94.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow

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