抗Human/Rat CCR4 Fluorescein抗体(Anti-Human/Rat CCR4 Fluorescein antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human, Rat
Label	Fluorescein
Immunogen	Human CCR4 transfectantsMet1-Leu360Accession # P51679
Source	Monoclonal Mouse IgG2B Clone # 205410
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Stains human CCR4-transfected cell lines but not the corresponding parent cell lines. Also detects human CCR4 on human PBLs and platelets and rat CCR4 on rat splenocytes.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry

Detection of CCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human/Rat CCR4 Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB1567F) and Mouse Anti-Human CD3 epsilon APC‑conjugated Monoclonal Antibody (Catalog # FAB100A). Quadrant markers were set based on control antibody staining (Catalog # IC0041F). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Entrez Gene IDs	1233 (Human); 12773 (Mouse); 171054 (Rat)
Background	CCR4
background_content	Background: CCR4 CCR4 is a G protein-linked seven transmembrane domain chemokine receptor that binds the chemokines CCL17/TARC and CCL22/MDC. Current evidence suggests that CCR4 expression is associated with Th-2 type T cells and with platelets. CCR4 expression has also been reported in mature dendritic cells.

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Citations

1. Histone deacetylase inhibitors downregulate CCR4 expression and decrease mogamulizumab efficacy in CCR4-positive mature T-cell lymphomas
   Authors: A Kitadate, S Ikeda, F Abe, N Takahashi, N Shimizu, K Matsue, H Tagawa
   Haematologica, 2017;0(0):.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome.
   Authors: James E, Gates T, LaFond R, Yamamoto S, Ni C, Mai D, Gersuk V, O'Brien K, Nguyen Q, Zeitner B, Lanteri M, Norris P, Chaussabel D, Malhotra U, Kwok W
   PLoS Pathog, 2016;12(1):e1005375.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


3. Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and Cytotoxicity
   Authors: Zaidoon Al-Jaderi
   Front Immunol, 2016;7(0):437.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


4. Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin
   Authors: Zhirui Wang
   Vet. Immunol. Immunopathol., 2016;182(0):150-158.
   Species: Porcine
   Sample Type: Whole Blood
   Application: Flow


5. Identification of human NK17/NK1 cells.
   Authors: Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA
   PLoS ONE, 2011;6(10):e26780.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


6. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
   Authors: Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH
   J. Immunol., 2010;184(6):2886-98.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


7. Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression.
   Authors: Brucklacher-Waldert V, Steinbach K, Lioznov M, Kolster M, Holscher C, Tolosa E
   J. Immunol., 2009;183(9):5494-501.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


8. Homeostatic regulation of T effector to Treg ratios in an area of seasonal malaria transmission.
   Authors: Finney OC, Nwakanma D, Conway DJ, Walther M, Riley EM
   Eur. J. Immunol., 2009;39(5):1288-300.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


9. Chemokine receptor expression on allergen-specific T cells in asthma and allergic bronchopulmonary aspergillosis.
   Authors: Garcia G, Humbert M, Capel F, Rimaniol AC, Escourrou P, Emilie D, Godot V
   Allergy, 2007;62(2):170-7.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


10. CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors.
    Authors: Baatar D, Olkhanud P, Newton D, Sumitomo K, Biragyn A
    J. Immunol., 2007;179(3):1996-2004.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow

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