抗NKG2A/CD159a抗体(Anti-Human NKG2A Phycoerythrin antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Phycoerythrin
Immunogen	BaF3 mouse pro-B cell line transfected with human NKG2A and CD94
Source	Monoclonal Mouse IgG2A Clone # 131411
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Recognizes the human NKG2A/CD94 heterodimer. It does not recognize the NKG2C/CD94 heterodimer or the CD94 homodimer.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry

Detection of NKG2A/CD159a in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM‑1/CD56 APC‑conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Mouse Anti-Human NKG2A/CD159a PE‑conjugated Monoclonal Antibody (Catalog # FAB1059P) or (B) Mouse IgG2A Phycoerythrin Isotype Control (Catalog # IC003P). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Long Name	Natural Killer G2A
Background	NKG2A/CD159a
background_content	Background: NKG2A/CD159a NKG2A is a type II transmembrane receptor having a single extracellular lectin-like domain and a cytoplasmic ITIM motif. It associates with CD94 and is expressed on NK cells and some activated T cell populations. The NKG2A/CD94 complex delivers an inhibitory signal upon recognition of its ligand, HLA-E.

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Citations

1. Varicella zoster virus productively infects human natural killer cells and manipulates phenotype
   Authors: TM Campbell, BP McSharry, M Steain, TM Ashhurst, B Slobedman, A Abendroth
   PLoS Pathog., 2018;14(4):e1006999.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-? and Engagement of CD85j
   Authors: SY Nuñez, A Ziblat, F Secchiari, NI Torres, JM Sierra, XL Raffo Irao, RE Araya, CI Domaica, MB Fuertes, NW Zwirner
   J. Immunol., 2017;0(0):.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


3. Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-?-dependent emperipolesis in HBV cirrhotic patients
   Authors: J Shi, J Zhao, X Zhang, Y Cheng, J Hu, Y Li, X Zhao, Q Shang, Y Sun, B Tu, L Shi, B Gao, FS Wang, Z Zhang
   Sci Rep, 2017;7(0):44544.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


4. Eomesodermin and T-bet mark developmentally distinct human natural killer cells
   Authors: A Collins, N Rothman, K Liu, SL Reiner
   JCI Insight, 2017;2(5):e90063.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


5. CD3(bright)CD56(+) T cells associate with pegylated interferon-alpha treatment nonresponse in chronic hepatitis B patients
   Sci Rep, 2016;6(0):25567.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


6. IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner
   Authors: Romain Loyon
   J Immunol, 2016;197(1):85-96.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


7. Overexpression of CD85j in TNBC patients inhibits Cetuximab-mediated NK-cell ADCC but can be restored with CD85j functional blockade.
   Authors: Roberti M, Julia E, Rocca Y, Amat M, Bravo A, Loza J, Colo F, Loza C, Fabiano V, Maino M, Podhorzer A, Fainboim L, Barrio M, Mordoh J, Levy E
   Eur J Immunol, 2015;45(5):1560-9.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


8. Regulatory Dendritic Cells Restrain NK Cell IFN-gamma Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors.
   Authors: Spallanzani R, Torres N, Avila D, Ziblat A, Iraolagoitia X, Rossi L, Domaica C, Fuertes M, Rabinovich G, Zwirner N
   J Immunol, 2015;195(5):2141-8.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


9. Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts.
   Authors: Picardi A, Mengarelli A, Marino M, Gallo E, Benevolo M, Pescarmona E, Cocco R, Fraioli R, Tremante E, Petti M, De Fabritiis P, Giacomini P
   J Exp Clin Cancer Res, 2015;34(0):98.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


10. NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure.
    Authors: Zou Y, Bao J, Pan X, Lu Y, Liao S, Wang X, Wang G, Lin D
    PLoS ONE, 2015;10(8):e0134568.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow

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