抗Human GITR Ligand/TNFSF18抗体(Anti-Human GITR Ligand/TNFSF18 antibody)
掲載日情報：2021/01/28 現在Webページ番号：30123
Human GITR Ligand/TNFSF18に対する抗体(Anti-Human GITR Ligand/TNFSF18 )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2026年04月06日 20時55分現在]
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Anti-Human GITR Ligand/TNFSF18 MAb (Clone 109114) |
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Anti-Human GITR Ligand/TNFSF18 MAb (Clone 109114) |
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Anti-Human GITR Ligand/TNFSF18 MAb (Clone 109114) |
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[在庫・価格 ：2026年04月06日 20時55分現在]
Anti-Human GITR Ligand/TNFSF18 MAb (Clone 109114)
文献数： 4
- 商品コード：MAB6942-100
- メーカー：RSD
- 包装：100μg
- 価格：¥78,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 別名：Activation-inducible TNF-related ligand クローン：109114 Genbank No： 8995 Protein Accession No： Q9UNG2 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | 法規備考 | ||||||
| 抗原種 | 免疫動物 | Mouse | |||||
| 交差性 | Human | 適用 | Blocking,ELISA,FCM | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | |||||||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Human GITR Ligand/TNFSF18 MAb (Clone 109114)
文献数： 4
- 商品コード：MAB6942-500
- メーカー：RSD
- 包装：500μg
- 価格：¥259,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human GITR Ligand/TNFSF18 サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAM6943，スタンダードとして#694-GL-025を用いる。 別名：Activation-inducible TNF-related ligand クローン：109114 Genbank No： 8995 Protein Accession No： Q9UNG2 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | 法規備考 | ||||||
| 抗原種 | 免疫動物 | Mouse | |||||
| 交差性 | Human | 適用 | Blocking,ELISA,FCM | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | |||||||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Human GITR Ligand/TNFSF18 MAb (Clone 109114)
文献数： 4
- 商品コード：MAB6942-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥25,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：Activation-inducible TNF-related ligand クローン：109114 Genbank No： 8995 Protein Accession No： Q9UNG2 |
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|---|---|---|---|---|---|---|---|
| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | 法規備考 | ||||||
| 抗原種 | 免疫動物 | Mouse | |||||
| 交差性 | Human | 適用 | Blocking,ELISA,FCM | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
|
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| 製品記事 | 使いっきり抗体 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human |
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| Label | Unconjugated |
| Immunogen | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human GITR Ligand/TNFSF18Glu52-Ser177Accession # Q9UNG2 |
| Source | Monoclonal Mouse IgG1 Clone # 109114 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects human GITR Ligand/TNFSF18 in ELISAs. In sandwich immunoassays, no cross-reactivity or interference with recombinant human (rh) APRIL, rhLIGHT, rhTNF-alpha, or rhVEGI is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Flow Cytometry | 2.5 µg/106 cells | HUVEC human umbilical vein endothelial cells |
| Blockade of Receptor-ligand Interaction | In a functional ELISA, 0.02-0.06 µg/mL of this antibody will block 50% of the binding of 10 ng/mL of biotinylated Recombinant Human GITR Ligand to immobilized Recombinant Human GITR/TNFRSF18 Fc Chimera (Catalog # 689-GR) coated at 2 µg/mL (100 µL/well). At 1 μg/mL, this antibody will block >90% of the binding. | |
| CyTOF-ready | Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation. | |
| Human GITR Ligand/TNFSF18 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human GITR Ligand/TNFSF18 Antibody (Catalog #MAB6942 ) |
| ELISA Detection (Matched Antibody Pair) | 0.5-2.0 µg/mL | Human GITR Ligand/TNFSF18 Biotinylated Antibody (Catalog #BAM6943 ) |
| ELISA Standard | Recombinant Human GITR Ligand/TNFSF18 Protein (Catalog #694-GL ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: GITR Ligand/TNFSF18 | GITR (glucocorticoid-induced TNF receptor superfamily-related protein, also named AITR, activation-inducible TNF receptor superfamily-related protein) and GITR Ligand (GITRL) are novel members of the TNF receptor (TNFR) and TNF superfamilies (SF) that have been designated TNFRSF18 and TNFSF18, respectively. Human GITR Ligand cDNA encodes a 177 amino acid type II membrane protein. The carboxy-terminal extracellular domain shows sequence identity to TNF/TNFSF2 (21%), Fas ligand/TNFSF6 (21%), TRAIL/TNFSF10 (18%), and lymphotoxin alpha /TNFSF1 (18%). GITR Ligand is constitutively expressed in human umbilical vein endothelial cells but is not expressed in resting or stimulated T cell lines, B cell lines or peripheral blood mononuclear cells. GITR, the receptor for GITR Ligand, is expressed at low levels in peripheral blood T cells, bone marrow, thymus, spleen and lymph nodes. In contrast to mouse GITR, expression of human GITR is not induced by treatment with dexamethasone, but is up-regulated by antigen-receptor stimulation or by treatment with soluble anti-CD3 plus anti-CD28 or PMA plus ionomycin. Ligation of GITR has been found to induce nuclear factor (NF)-kappa B activation via TNF receptor-associated factor 2 and protect cells from TCR activation-induced cell death. It has been proposed that GITR Ligand and GITR may modulate T lymphocyte functions in peripheral tissues. |
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References
| Nocentini, G. et al. (1997) Proc. Natl. Acad. Sci. USA 94:6216. | |
| Kwon, B. et al. (1999) J. Biol. Chem. 274:6056. | |
| Gurney, A.L. et al. (1999) Curr. Biol. 9:215. | |
| Kwon, B. et al. (1999) Curr. Opin. Immunol. 11:340. | |
| Long Name: | Glucocorticoid Induced TNF Receptor Family Related Gene Ligand |
| Entrez Gene IDs: | 8995 (Human); 240873 (Mouse); 364031 (Rat) |
| Alternate Names: | Activation-inducible TNF-related ligand; AITRLMGC138237; GITR Ligand; GITRL; GITRLglucocorticoid-induced TNFR-related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRLGITR ligand; TL6AITR ligand; TNFSF18; tumor necrosis factor (ligand) superfamily, member 18; tumor necrosis factor ligand superfamily member 18 |
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Related Research Areas
| Common Macrophage Markers | ||
| Co-stimulatory and Co-inhibitory Molecules | ||
| Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members | ||
| Regulation of T Cell Co-stimulation by TNF Superfamily Members | ||
| Regulatory T Cells (Tregs) | ||
| TNF Superfamily | ||
| TNF Superfamily Ligands | ||
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Related Product & Information
| Long Name | Glucocorticoid Induced TNF Receptor Family Related Gene Ligand |
|---|---|
| Entrez Gene IDs | 8995 (Human); 240873 (Mouse); 364031 (Rat) |
| Background | GITR Ligand/TNFSF18 |
| background_content | Background: GITR Ligand/TNFSF18 GITR (glucocorticoid-induced TNF receptor superfamily-related protein, also named AITR, activation-inducible TNF receptor superfamily-related protein) and GITR Ligand (GITRL) are novel members of the TNF receptor (TNFR) and TNF superfamilies (SF) that have been designated TNFRSF18 and TNFSF18, respectively. Human GITR Ligand cDNA encodes a 177 amino acid type II membrane protein. The carboxy-terminal extracellular domain shows sequence identity to TNF/TNFSF2 (21%), Fas ligand/TNFSF6 (21%), TRAIL/TNFSF10 (18%), and lymphotoxin alpha /TNFSF1 (18%). GITR Ligand is constitutively expressed in human umbilical vein endothelial cells but is not expressed in resting or stimulated T cell lines, B cell lines or peripheral blood mononuclear cells. GITR, the receptor for GITR Ligand, is expressed at low levels in peripheral blood T cells, bone marrow, thymus, spleen and lymph nodes. In contrast to mouse GITR, expression of human GITR is not induced by treatment with dexamethasone, but is up-regulated by antigen-receptor stimulation or by treatment with soluble anti-CD3 plus anti-CD28 or PMA plus ionomycin. Ligation of GITR has been found to induce nuclear factor (NF)-kappa B activation via TNF receptor-associated factor 2 and protect cells from TCR activation-induced cell death. It has been proposed that GITR Ligand and GITR may modulate T lymphocyte functions in peripheral tissues. |
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Citations
- Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells.
Authors: Tuyaerts S, Van Meirvenne S, Bonehill A, Heirman C, Corthals J, Waldmann H, Breckpot K, Thielemans K, Aerts JL
J. Leukoc. Biol., 2007;82(1):93-105.
Species: Human
Sample Type: Whole Cells
Application: Flow - Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions.
Authors: Baltz KM, Krusch M, Bringmann A, Brossart P, Mayer F, Kloss M, Baessler T, Kumbier I, Peterfi A, Kupka S, Kroeber S, Menzel D, Radsak MP, Rammensee HG, Salih HR
FASEB J., 2007;21(10):2442-54.
Species: Human
Sample Type: Whole Cells
Application: Flow - Expression of GITR ligand abrogates immunosuppressive function of ocular tissue and differentially modulates inflammatory cytokines and chemokines.
Authors: Mahesh SP, Li Z, Liu B, Fariss RN, Nussenblatt RB
Eur. J. Immunol., 2006;36(8):2128-38.
Species: Human
Sample Type: Cell Culture Supernates
Application: ELISA Development - Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis.
Authors: Baumgartner-Nielsen J, Vestergaard C, Thestrup-Pedersen K
Acta Derm. Venereol., 2006;86(5):393-8.
Species: Human
Sample Type: Whole Tissue
Application: IHC Frozen
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