抗Mouse CXCL13/BLC/BCA-1抗体(Anti-Mouse CXCL13/BLC/BCA-1 antibody)
掲載日情報：2021/01/28 現在Webページ番号：30037
Mouse CXCL13/BLC/BCA-1に対する抗体(Anti-Mouse CXCL13/BLC/BCA-1 )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- Data Examples
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年04月26日 20時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-Mouse CXCL13/BLC/BCA-1 MAb (Clone 143614) |
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Anti-Mouse CXCL13/BLC/BCA-1 MAb (Clone 143614) |
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Anti-Mouse CXCL13/BLC/BCA-1 MAb (Clone 143614) |
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[在庫・価格 ：2025年04月26日 20時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-Mouse CXCL13/BLC/BCA-1 MAb (Clone 143614)
文献数： 0
- 商品コード：MAB470-100
- メーカー：RSD
- 包装：100μg
- 価格：¥101,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 別名：ANGIE クローン：143614 Genbank No： 10563 Protein Accession No： O55038 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Rat | |||||
| 交差性 | Mouse | 適用 | ELISA,Neutralising | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | M1/M2 Macrophage Activation Marker |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Mouse CXCL13/BLC/BCA-1 MAb (Clone 143614)
文献数： 0
- 商品コード：MAB470-500
- メーカー：RSD
- 包装：500μg
- 価格：¥232,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Mouse CXCL13/BLC/BCA-1 サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAF470，スタンダードとして#470-BC-025を用いる。 別名：ANGIE クローン：143614 Genbank No： 10563 Protein Accession No： O55038 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Rat | |||||
| 交差性 | Mouse | 適用 | ELISA,Neutralising | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | M1/M2 Macrophage Activation Marker |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Mouse CXCL13/BLC/BCA-1 MAb (Clone 143614)
文献数： 0
- 商品コード：MAB470-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：ANGIE クローン：143614 Genbank No： 10563 Protein Accession No： O55038 |
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|---|---|---|---|---|---|---|---|
| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Rat | |||||
| 交差性 | Mouse | 適用 | ELISA,Neutralising | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
|
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| 製品記事 | M1/M2 Macrophage Activation Marker 使いっきり抗体 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Mouse |
|---|---|
| Label | Unconjugated |
| Immunogen | E. coli-derived recombinant mouse CXCL13Ile22-Ala109Accession # O55038 |
| Source | Monoclonal Rat IgG2A Clone # 143614 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects mouse CXCL13 in ELISAs. In ELISAs, this antibody does not cross-react with recombinant human (rh) CXCL13, rmCXCL11/I‑TAC, rmCXCL9/MIG, or rm CXCL12/SDF‑1 alpha. |
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Applications and Data
| Recommended Concentration | Sample | |
| Mouse CXCL13/BLC/BCA-1 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Mouse CXCL13/BLC/BCA‑1 Antibody (Catalog #MAB470 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse CXCL13/BLC/BCA‑1 Biotinylated Antibody (Catalog #BAF470 ) |
| ELISA Standard | Recombinant Mouse CXCL13/BLC/BCA-1 Protein (Catalog #470-BC ) | |
| Neutralization | Measured by its ability to neutralize CXCL13/BLC/BCA‑1-induced chemotaxis in the BaF3 mouse pro‑B cell line transfected with human CXCR5. The Neutralization Dose (ND50) is typically 12-30 µg/mL in the presence of 4 µg/mL Recombinant Mouse CXCL13/BLC/BCA‑1. | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | ||
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Data Examples
| Neutralization |
![Neutralization CXCL13/BLC/BCA-1 Antibody (143614) [Unconjugated]](http://resources.rndsystems.com/images/datasheets/antibody/CXCL13_MAB470_Block_Neutralize_9206.jpg) click image to view larger | Chemotaxis Induced by CXCL13/BLC/BCA‑1 and Neutralization by Mouse CXCL13/BLC/BCA‑1 Antibody.Recombinant Mouse CXCL13/BLC/BCA‑1 (Catalog # 470-BC) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR5 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Mouse CXCL13/BLC/BCA‑1 (4 µg/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse CXCL13/BLC/BCA‑1 Monoclonal Antibody (Catalog # MAB470). The ND50 is typically 12-30 µg/mL. |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: CXCL13/BLC/BCA-1 | CXCL13, also known as B-lymphocyte chemoattractant (BLC) and BCA-1, is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Mouse CXCL13 cDNA encodes a precursor protein of 109 amino acid residues with a putative leader sequence of 21 residues. Mature mouse CXCL13 shares 64% amino acid sequence similarity with the human protein and 23-34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized CXCL13 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for CXCL13. Among cells of the hematopoietic lineages, the expression of BLR1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. Mice lacking BLR1 have been shown to lack inguinal lymph nodes. These mice were also found to have impaired development of Peyer’s patches and defective formation of primary follicles and germinal centers in the spleen as a result of the inability of B lymphocytes to migrate into B cell areas. |
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References
| Gunn, M.D. et al. (1998) Nature, 391:799. | |
| Legler, D.F. et al. (1998) J. Exp. Med. 187:655. | |
| Forster, R. et al. (1996) Cell 87:1037. | |
| Entrez Gene IDs: | 10563 (Human); 55985 (Mouse) |
| Alternate Names: | ANGIE; ANGIE2; B cell-attracting chemokine 1; B lymphocyte chemoattractant; BCA1; BCA-1; BCA1B-cell chemoattractant; BCA-1CXC chemokine BLC; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); BLC; BLCSmall-inducible cytokine B13; BLR1L; B-lymphocyte chemoattractant; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); chemokine (C-X-C motif) ligand 13; C-X-C motif chemokine 13; CXCL13; SCYB13B-cell-attracting chemokine 1; small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant) |
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Related Research Areas
| B Cell Chemotaxis, Migration, and Adhesion | ||
| Chemokines and Receptors | ||
| Chemokines and Receptors in Angiogenesis | ||
| Chemokines and Receptors in Tfh Cell Differentiation and Function | ||
| CXC Chemokines and Receptors | ||
| gamma delta T Cells | ||
| Macrophage Activation Markers | ||
| Molecules Secreted by VSMC | ||
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| Neutralization | |
|---|---|
 | Chemotaxis Induced by CXCL13/BLC/BCA‑1 and Neutralization by Mouse CXCL13/BLC/BCA‑1 Antibody. Recombinant Mouse CXCL13/BLC/BCA‑1 (Catalog # 470-BC) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR5 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Mouse CXCL13/BLC/BCA‑1 (4 µg/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse CXCL13/BLC/BCA‑1 Monoclonal Antibody (Catalog # MAB470). The ND50 is typically 12-30 µg/mL. |
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Related Product & Information
| Entrez Gene IDs | 10563 (Human); 55985 (Mouse) |
|---|---|
| Background | CXCL13/BLC/BCA-1 |
| background_content | Background: CXCL13/BLC/BCA-1 CXCL13, also known as B-lymphocyte chemoattractant (BLC) and BCA-1, is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Mouse CXCL13 cDNA encodes a precursor protein of 109 amino acid residues with a putative leader sequence of 21 residues. Mature mouse CXCL13 shares 64% amino acid sequence similarity with the human protein and 23-34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized CXCL13 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for CXCL13. Among cells of the hematopoietic lineages, the expression of BLR1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. Mice lacking BLR1 have been shown to lack inguinal lymph nodes. These mice were also found to have impaired development of Peyer’s patches and defective formation of primary follicles and germinal centers in the spleen as a result of the inability of B lymphocytes to migrate into B cell areas. |
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products.The data collected includes not only links to publications in PubMed,but also provides information about sample types, species, and experimental conditions.
- Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells.
Authors: Leon B, Ballesteros-Tato A, Browning JL, Dunn R, Randall TD, Lund FE
Nat. Immunol., 2102;13(7):681-90.
Species: Mouse
Sample Type: In Vivo
Application: In vivo - CXCL13 antibody for the treatment of autoimmune disorders.
Authors: Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, Jonason A, Mallow C, Doherty M, Paris M, Smith E, Zauderer M
BMC Immunol, 2015;16(0):6. - CXCL13 is elevated in Sjogren's syndrome in mice and humans and is implicated in disease pathogenesis.
Authors: Kramer J, Klimatcheva E, Rothstein T
J Leukoc Biol, 2013;94(5):1079-89.
Species: Mouse
Sample Type: Whole Cells
Application: Neut - Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage.
J. Immunol., 2012;189(5):2181-90.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Frozen - Response patterns of cytokines/chemokines in two murine strains after irradiation.
Authors: Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, Salzman P, Wang W, Liu C, Vidyasagar S, Zhang L, Ju S, Okunieff P, Zhang L
Cytokine, 2012;58(2):169-77.
Species: Mouse
Sample Type: Plasma
Application: Luminex Assay Development - Unique requirements for reactivation of virus-specific memory B lymphocytes.
Authors: Weisel FJ, Appelt UK, Schneider AM, Horlitz JU, Van Rooijen N, Korner H, Mach M, Winkler TH
J. Immunol., 2010;185(7):4011-21.
Species: Mouse
Sample Type: In Vivo
Application: In vivo
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