抗TNF Receptor Ⅱ/TNFRSF1B抗体(Anti-TNF Receptor Ⅱ/TNFRSF1B, Mouse, Hamster-Mono antibody)
掲載日情報：2021/01/28 現在Webページ番号：30030
TNF Receptor Ⅱ/TNFRSF1Bに対する抗体(Anti-TNF Receptor Ⅱ/TNFRSF1B, Mouse, Hamster-Mono )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- Data Examples
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2026年04月06日 18時15分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-TNF Receptor II/TNFRSF1B, Mouse, Hamster-Mono(TR7554) |
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Anti-Mouse TNF RII/TNFRSF1B MAb (Clone TR7554) |
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[在庫・価格 ：2026年04月06日 18時15分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-TNF Receptor II/TNFRSF1B, Mouse, Hamster-Mono(TR7554)
文献数： 4
- 商品コード：MAB426
- メーカー：RSD
- 包装：500μg
- 価格：¥93,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Mouse TNF RII/TNFRSF1B サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAF426，スタンダードとして#426-R2-050を用いる。 別名：CD120b クローン：TR7554 Genbank No： 7133 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | Mouse | 免疫動物 | Hamster | ||||
| 交差性 | Mouse | 適用 | ELISA,FCM,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | |||||||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Mouse TNF RII/TNFRSF1B MAb (Clone TR7554)
文献数： 4
- 商品コード：MAB426-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥25,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：CD120b クローン：TR7554 Genbank No： 7133 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | 法規備考 | ||||||
| 抗原種 | 免疫動物 | Hamster | |||||
| 交差性 | Mouse | 適用 | ELISA,FCM,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | 使いっきり抗体 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Mouse |
|---|---|
| Label | Unconjugated |
| Immunogen | E. coli-derived recombinant mouse TNF RII/TNFRSF1BExtracellular domain |
| Source | Monoclonal Hamster IgG Clone # TR7554 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects mouse TNF RII/TNFRSF1B in ELISAs and Western blots. In ELISAs, no cross-reactivity with recombinant human (rh) TNF RII, recombinant mouse (rm) TNF RI, rhTNF RI, rm4‑1BB, or rmOPG is observed. In Western blots, approximately 25% cross-reactivity with rhDR3 and rhTNF RII is observed and no cross-reactivity with rm4‑1BB, rmCD27, rmCD30, rmCD40, rmFas, rmGITR, rhHVEM, rhNGF R, rmOPG, rmRANK, rmTNF RI, rmTROY, or rmEDAR is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 1 µg/mL | Recombinant Mouse TNF RII/TNFRSF1B (Catalog # 426-R2) |
| Flow Cytometry | 1 µg/106 cells | See below |
| CyTOF-ready | Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation. | |
| Mouse TNF RII/TNFRSF1B Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Mouse TNF RII/TNFRSF1B Antibody (Catalog #MAB426 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse TNF RII/TNFRSF1B Biotinylated Antibody (Catalog #BAF426 ) |
| ELISA Standard | Recombinant Mouse sTNF RII/TNFRSF1B Protein (Catalog #426-R2 ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | ||
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Data Examples
| Flow Cytometry |
![Flow Cytometry TNF RII/TNFRSF1B Antibody (TR7554) [Unconjugated]](http://resources.rndsystems.com/images/datasheets/antibody/TNF_RII_MAB426_Flow_Cytometry_9309.jpg) click image to view larger | Detection of TNF RII/TNFRSF1B in L‑929 Mouse Cell Line by Flow Cytometry.L‑929 mouse fibroblast cell line was stained with Hamster Anti-Mouse TNF RII/ TNFRSF1B Monoclonal Antibody (Catalog # MAB426, filled histogram) or isotype control antibody (open histogram), followed by Phycoerythrin-conjugated Anti-Hamster IgG Secondary Antibody (Catalog # F0120). |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: TNF RII/TNFRSF1B | Two types of soluble TNF receptors have been identified in human serum and urine which can neutralize the biological activities of TNF-alpha and TNF-beta. These binding proteins represent truncated forms of the two types of high-affinity cell surface receptors for TNF (TNFR-p60 Type B and TNFR-p80 Type A). Soluble TNF RII corresponds to TNFR-p80 Type A. In the new TNF superfamily nomenclature, TNF RII is referred to as TNFRSF1B. These apparent soluble forms of the receptors appear to arise as a result of shedding of the extracellular domains of the membrane-bound receptors. Normal concentrations as high as 4 ng/mL are found in the serum of healthy individuals, and even higher levels may be found in some pathological conditions. Although the physiological role of these proteins is not known, it has been speculated that shedding of the soluble receptors in response to TNF release could serve as a mechanism to scavenge the TNF not immediately bound and thus localize the inflammatory response. It is also possible that the pool of TNF bound to soluble receptors could represent a reservoir for the controlled release of TNF. |
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| Long Name: | Tumor Necrosis Factor Receptor II | |
| Entrez Gene IDs: | 7133 (Human); 21938 (Mouse); 156767 (Rat) | |
| Alternate Names: | CD120b antigen; CD120b; Etanercept; p75 TNF receptor; p75TBPII; p75TNFR; soluble TNFR1B variant 1; TNF RII; TNFBRp80 TNF-alpha receptor; TNF-R2; TNFR2TNFR1B; TNF-R75; TNFR80; TNFRII; TNF-RII; TNF-R-II; TNFR-II; TNFRSF1B; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor type II | |
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Related Research Areas
| Adipocytokines | ||
| Cell Structure and Signaling Molecules | ||
| Co-stimulatory and Co-inhibitory Molecules | ||
| Cytokines and Receptors in Allergy and Asthma | ||
| Cytokines and Receptors in Angiogenesis | ||
| Diabetes | ||
| Diabetic Peripheral Neuropathy | ||
| Endothelial Cell Markers | ||
| Neuroinflammation | ||
| Obesity | ||
| Platelet Cytokine and Growth Factor Receptors | ||
| Regulation of Apoptosis by TNF Superfamily Members | ||
| Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members | ||
| Regulation of T Cell Co-stimulation by TNF Superfamily Members | ||
| Regulatory T Cells (Tregs) | ||
| T Cell Cytokine Signaling | ||
| TNF Superfamily | ||
| TNF Superfamily Receptors | ||
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| Flow Cytometry | |
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 | Detection of TNF RII/TNFRSF1B in L‑929 Mouse Cell Line by Flow Cytometry. L‑929 mouse fibroblast cell line was stained with Hamster Anti-Mouse TNF RII/TNFRSF1B Monoclonal Antibody (Catalog # MAB426, filled histogram) or isotype control antibody (open histogram), followed by Phycoerythrin-conjugated Anti-Hamster IgG Secondary Antibody (Catalog # F0120). |
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Related Product & Information
| Background | TNF RII/TNFRSF1B |
|---|---|
| background_content | Background: TNF RII/TNFRSF1B Two types of soluble TNF receptors have been identified in human serum and urine which can neutralize the biological activities of TNF-alpha and TNF-beta. These binding proteins represent truncated forms of the two types of high-affinity cell surface receptors for TNF (TNFR-p60 Type B and TNFR-p80 Type A). Soluble TNF RII corresponds to TNFR-p80 Type A. In the new TNF superfamily nomenclature, TNF RII is referred to as TNFRSF1B. These apparent soluble forms of the receptors appear to arise as a result of shedding of the extracellular domains of the membrane-bound receptors. Normal concentrations as high as 4 ng/mL are found in the serum of healthy individuals, and even higher levels may be found in some pathological conditions. Although the physiological role of these proteins is not known, it has been speculated that shedding of the soluble receptors in response to TNF release could serve as a mechanism to scavenge the TNF not immediately bound and thus localize the inflammatory response. It is also possible that the pool of TNF bound to soluble receptors could represent a reservoir for the controlled release of TNF. |
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
- Activated CD8+ T cells induce expansion of Vbeta5+ regulatory T cells via TNFR2 signaling.
Authors: Joedicke J, Myers L, Carmody A, Messer R, Wajant H, Lang K, Lang P, Mak T, Hasenkrug K, Dittmer U
J Immunol, 2014;193(6):2952-60.
Species: Mouse
Sample Type: Whole Cells
Application: Flow - Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.
Authors: Osuchowski MF, Welch K, Siddiqui J, Remick DG
J. Immunol., 2006;177(3):1967-74.
Species: Mouse
Sample Type: Plasma
Application: ELISA Development - Sequential ELISA to profile multiple cytokines from small volumes.
Authors: Osuchowski MF, Siddiqui J, Copeland S, Remick DG
J. Immunol. Methods, 2005;302(1):172-81.
Species: Mouse
Sample Type: Plasma
Application: ELISA Development - Selective macrophage suppression during sepsis.
Authors: Ellaban E, Bolgos G, Remick D
Cell. Immunol., 2004;231(1):103-11.
Species: Mouse
Sample Type: Cell Culture Supernates
Application: ELISA Development
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