抗Mouse CD45抗体(Anti-Mouse CD45 antibody)
掲載日情報:2018/11/26 現在Webページ番号:29977
Mouse CD45に対する抗体(Anti-Mouse CD45 )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2025年06月25日 17時15分現在]
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Anti-Mouse CD45 MAb (Clone 30-F11) |
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Anti-Mouse CD45 MAb (Clone 30-F11) |
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Anti-Mouse CD45 MAb (Clone 30-F11) |
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[在庫・価格 :2025年06月25日 17時15分現在]
Anti-Mouse CD45 MAb (Clone 30-F11)
文献数: 1
- 商品コード:MAB114-100
- メーカー:RSD
- 包装:100μg
- 価格:¥100,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 別名:B220 クローン:30-F11 Genbank No: 5788 |
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別包装品 | 別包装品あり | ||||||
法規制等 | |||||||
保存条件 | -20℃ | 法規備考 | |||||
抗原種 | 免疫動物 | Rat | |||||
交差性 | Mouse | 適用 | FCM,IC,IHC,IP | ||||
標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Monoclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | 抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社) |
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関連記事 |
Anti-Mouse CD45 MAb (Clone 30-F11)
文献数: 1
- 商品コード:MAB114-500
- メーカー:RSD
- 包装:500μg
- 価格:¥232,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 別名:B220 クローン:30-F11 Genbank No: 5788 |
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別包装品 | 別包装品あり | ||||||
法規制等 | |||||||
保存条件 | 法規備考 | ||||||
抗原種 | 免疫動物 | Rat | |||||
交差性 | Mouse | 適用 | FCM,IC,IHC,IP | ||||
標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Monoclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | 抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社) |
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関連記事 |
Anti-Mouse CD45 MAb (Clone 30-F11)
文献数: 1
- 商品コード:MAB114-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥30,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | ※受注発注品。形状:溶液または凍結乾燥 別名:B220 クローン:30-F11 Genbank No: 5788 |
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別包装品 | 別包装品あり | ||||||
法規制等 | |||||||
保存条件 | -20℃ | 法規備考 | |||||
抗原種 | 免疫動物 | Rat | |||||
交差性 | Mouse | 適用 | FCM,IC,IHC,IP | ||||
標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Monoclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | 抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社) 使いっきり抗体 |
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関連記事 |
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Product Details
Species Reactivity | Mouse |
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Label | Unconjugated |
Immunogen | Mouse thymus and spleen cells |
Source | Monoclonal Rat IgG2B Clone # 30-F11 |
Purification | Protein A or G purified from hybridoma culture supernatant |
Specificity | Detects mouse CD45. Recognizes all CD45 isoforms as well as the known mouse CD45 alloantigens (CD45-1/Ly 5a and CD45-2/Ly 5b) (15). |
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Applications and Data
Recommended Concentration | Sample | |
Flow Cytometry | 2.5 µg/106 cells | Mouse splenocytes |
Immunohistochemistry | Simon, D.I. et al. (2000) J. Clin. Invest. 105:293. | |
Immunoprecipitation | Ledbetter, J.A. and L.A. Herzenberg (1979) Immunol. Rev. 47:63. | |
Complement-dependent Cytotoxicity | Ledbetter, J.A. and L.A. Herzenberg (1979) Immunol. Rev. 47:63. | |
CyTOF-reported | Lee, H. et al. (2015) Mucosal Immunol. 8: 1083. Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation. |
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Related Product & Information
Long Name | Cluster of Differentiation 45 |
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Entrez Gene IDs | 5788 (Human); 19264 (Mouse); 490255 (Canine); 100061950 (Equine) |
Background | CD45 |
background_content | Background: CD45 CD45, previously called LCA (leukocyte common antigen), T200, or Ly5 in mouse, is member C of the class 1 (receptor-like) protein tyrosine phosphatase family (PTPRC) (1, 2). It is a variably glycosylated 180‑220 kDa transmembrane protein that is abundantly expressed on all nucleated cells of hematopoietic origin (1‑3). CD45 has several isoforms, expressed according to cell type, developmental stage and antigenic exposure (1‑5). The longest form, CD45RABC (called B220 in mouse), is expressed on B lymphocytes (5). The mouse CD45RABC cDNA encodes 1291 amino acids (aa), including a 23 aa signal sequence, a 541 aa extracellular domain containing the splicing region, a cysteine-rich region and two fibronectin type III domains, a 22 aa transmembrane sequence, and a 705 aa cytoplasmic domain that contains two phosphatase domains, D1 and D2. Only D1 has phosphatase activity. CD45R0 is the shortest form, lacking exons 4, 5 and 6 which encodeaa 30‑169. It is expressed on memory cells, while intermediate sizes are expressed on other T cells (3, 4, 6). CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds (3, 6‑8). CD45 is moved into or out of the immunological synapse (IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton (9, 10). Galectin interaction can be fine-tuned by varying usage of the heavily O-glycosylated spliced regions and sialylation of N-linked carbohydrates (4, 9). Within the IS, CD45 dephosphorylates and negatively regulates the src family kinase, LCK (8‑10). In other leukocytes, CD45 influences differentiation and links immunoreceptor signaling with cytokine secretion and cell survival, partially overlapping in function with DEP-1/CD148 (11‑14). CD45 deletion causes in severe immunodeficiency, while point mutations may be associated with autoimmune disorders (6, 7). |
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Citations
- UHRF1 epigenetically orchestrates smooth muscle cell plasticity in arterial disease
Authors: L Elia, P Kunderfran, P Carullo, M Vacchiano, FM Farina, IF Hall, S Mantero, C Panico, R Papait, G Condorelli, M Quintavall
J. Clin. Invest., 2018;0(0):.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC - Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis
Authors: EN Komegae, TA Souza, LZ Grund, C Lima, M Lopes-Ferr
PLoS ONE, 2017;12(2):e0171796.
Species: Mouse
Sample Type: Whole Cells
Application: Flow - Combination of CD40 agonism and CSF-1R blockade reconditions tumor-associated macrophages and drives potent antitumor immunity
Authors: KR Wiehagen, NM Girgis, DH Yamada, AA Smith, SR Chan, IS Grewal, M Quigley, RI Verona
Cancer Immunol Res, 2017;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Flow - Growth inhibition of formed corneal neovascularization following Fosaprepitant treatment
Authors: F Bignami, A Lorusso, P Rama, G Ferrari
Acta Ophthalmol, 2017;0(0):.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC - Nucleosomes contribute to increase mesangial cell chemokine expression during the development of lupus nephritis.
Authors: Kanapathippillai P, Hedberg A, Fenton C, Fenton K
Cytokine, 2013;62(2):244-52.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC - Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis.
J Neuroinflammation, 2012;9(0):193.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Frozen - Long-term effects of polymer-based, slow-release, sirolimus-eluting stents in a porcine coronary model.
Authors: Carter AJ, Aggarwal M, Kopia GA, Tio F, Tsao PS, Kolata R, Yeung AC, Llanos G, Dooley J, Falotico R
Cardiovasc. Res., 2004;63(4):617-24.
Species: Porcine
Sample Type: Tissue Homogenates
Application: WB
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