抗GITR Ligand抗体(Anti-GITR Ligand, Human, Mouse-Mono, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：29909
GITR Ligandに対する抗体(Anti-GITR Ligand, Human, Mouse-Mono, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2026年04月06日 18時35分現在]
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Anti-GITR Ligand, Human, Mouse-Mono(109117), Biotin |
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[在庫・価格 ：2026年04月06日 18時35分現在]
Anti-GITR Ligand, Human, Mouse-Mono(109117), Biotin
文献数： 1
- 商品コード：BAM6943
- メーカー：RSD
- 包装：250μg
- 価格：¥93,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human GITR Ligand/TNFSF18 サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB6942-500，スタンダードとして#694-GL-025を用いる。 別名：Activation-inducible TNF-related ligand クローン：109117 Genbank No： 8995 Protein Accession No： Q9UNG2 |
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| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Human | 免疫動物 | Mouse |
| 交差性 | Human | 適用 | ELISA |
| 標識 | Biotin | 性状 | Protein A/G Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Monoclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | |||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human |
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| Label | Biotin |
| Immunogen | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human GITR LigandGlu52-Ser177Accession # Q9UNG2 |
| Source | Monoclonal Mouse IgG1 Clone # 109117 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects human GITR Ligand in ELISAs. In ELISAs, this antibody does not cross-react or interfere with recombinant human (rh) APRIL/TNFSF13, rhLIGHT/TNFSF14, rhTNF-alpha /TNFSF2, or rhVEGI/TNFSF15. |
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Applications and Data
| Recommended Concentration | Sample | |
| Human GITR Ligand/TNFSF18 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human GITR Ligand/TNFSF18 Antibody (Catalog #MAB6942 ) |
| ELISA Detection (Matched Antibody Pair) | 0.5-2.0 µg/mL | Human GITR Ligand/TNFSF18 Biotinylated Antibody (Catalog #BAM6943 ) |
| ELISA Standard | Recombinant Human GITR Ligand/TNFSF18 Protein (Catalog #694-GL ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: GITR Ligand/TNFSF18 | GITR (glucocorticoid-induced TNF receptor superfamily-related protein, also named AITR, activation-inducible TNF receptor superfamily-related protein) and GITR ligand (GITRL) are novel members of the TNF receptor (TNFR) and TNF superfamilies (SF) that have been designated TNFRSF18 and TNFSF18, respectively. Human GITRL cDNA encodes a 177 amino acid residues type II membrane protein. The carboxy-terminal extracellular domain shows sequence identity to TNF/TNFSF2 (21%), Fas ligand/TNFSF6 (21%), TRAIL/TNFSF10 (18%), and lymphotoxin alpha /TNFSF1 (18%). GITRL is constitutively expressed in human umbilical vein endothelial cells but is not expressed in resting or stimulated T cell lines, B cell lines or peripheral blood mononuclear cells. GITR, the receptor for GITRL, is expressed at low levels in peripheral blood T cells, bone marrow, thymus, spleen and lymph nodes. In contrast to mouse GITR, expression of human GITR is not induced by treatment with dexamethasone, but is up-regulated by antigen-receptor stimulation or by treatment with soluble anti-CD3 plus anti-CD28 or PMA plus ionomycin. Ligation of GITR has been found to induce nuclear factor (NF)-kappa B activation via TNF receptor-associated factor 2 and protect cells from TCR activation-induced cell death. It has been proposed that GITRL and GITR may modulate T lymphocyte functions in peripheral tissues. |
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References
| Nocentini, G. et al. (1997) Proc. Natl. Acad. Sci. USA 94:6216. | |
| Kwon, B. et al. (1999) J. Biol. Chem. 274:6056. | |
| Gurney, A.L. et al. (1999) Current Biology 9:215. | |
| Kwon, B. et al. (1999) Current Opinion in Immunology 11:340. | |
| Long Name: | Glucocorticoid Induced TNF Receptor Family Related Gene Ligand |
| Entrez Gene IDs: | 8995 (Human); 240873 (Mouse); 364031 (Rat) |
| Alternate Names: | Activation-inducible TNF-related ligand; AITRLMGC138237; GITR Ligand; GITRL; GITRLglucocorticoid-induced TNFR-related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRLGITR ligand; TL6AITR ligand; TNFSF18; tumor necrosis factor (ligand) superfamily, member 18; tumor necrosis factor ligand superfamily member 18 |
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Related Research Areas
| Common Macrophage Markers | ||
| Co-stimulatory and Co-inhibitory Molecules | ||
| Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members | ||
| Regulation of T Cell Co-stimulation by TNF Superfamily Members | ||
| Regulatory T Cells (Tregs) | ||
| TNF Superfamily | ||
| TNF Superfamily Ligands | ||
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Related Product & Information
| Background | GITR Ligand/TNFSF18 |
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| background_content | Background: GITR Ligand/TNFSF18 GITR (glucocorticoid-induced TNF receptor superfamily-related protein, also named AITR, activation-inducible TNF receptor superfamily-related protein) and GITR ligand (GITRL) are novel members of the TNF receptor (TNFR) and TNF superfamilies (SF) that have been designated TNFRSF18 and TNFSF18, respectively. Human GITRL cDNA encodes a 177 amino acid residues type II membrane protein. The carboxy-terminal extracellular domain shows sequence identity to TNF/TNFSF2 (21%), Fas ligand/TNFSF6 (21%), TRAIL/TNFSF10 (18%), and lymphotoxin alpha /TNFSF1 (18%). GITRL is constitutively expressed in human umbilical vein endothelial cells but is not expressed in resting or stimulated T cell lines, B cell lines or peripheral blood mononuclear cells. GITR, the receptor for GITRL, is expressed at low levels in peripheral blood T cells, bone marrow, thymus, spleen and lymph nodes. In contrast to mouse GITR, expression of human GITR is not induced by treatment with dexamethasone, but is up-regulated by antigen-receptor stimulation or by treatment with soluble anti-CD3 plus anti-CD28 or PMA plus ionomycin. Ligation of GITR has been found to induce nuclear factor (NF)-kappa B activation via TNF receptor-associated factor 2 and protect cells from TCR activation-induced cell death. It has been proposed that GITRL and GITR may modulate T lymphocyte functions in peripheral tissues. |
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Citations
- Expression of GITR ligand abrogates immunosuppressive function of ocular tissue and differentially modulates inflammatory cytokines and chemokines.
Authors: Mahesh SP, Li Z, Liu B, Fariss RN, Nussenblatt RB
Eur. J. Immunol., 2006;36(8):2128-38.
Species: Human
Sample Type: Cell Culture Supernates
Application: ELISA Development
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