抗Mer抗体(Anti-Mer, Human, Goat-Poly, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：29894
Merに対する抗体(Anti-Mer, Human, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Summary
- Summary
- Related Product & Information
- Citations
価格
[在庫・価格 ：2024年05月04日 00時00分現在]
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Anti-Mer, Human, Goat-Poly, Biotin |
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[在庫・価格 ：2024年05月04日 00時00分現在]
Anti-Mer, Human, Goat-Poly, Biotin
文献数： 2
- 商品コード：BAF891
- メーカー：RSD
- 包装：50μg
- 価格：¥113,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
マッチドペア：Human Mer サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB8912-500，スタンダードとして#891-MR-100を用いる。 別名：c-Eyk Genbank No： 10461 Protein Accession No： Q12866 |
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| 保存条件 | 法規備考 | ||
| 抗原種 | Human | 免疫動物 | Goat |
| 交差性 | Human | 適用 | ELISA,Western Blot |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | |||
| 関連記事 |
R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human |
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| Label | Biotin |
| Immunogen | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human MerArg26-Ala499Accession # Q12866 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects human Mer in ELISAs and Western blots. In sandwich immunoassays, approximately 6% cross-reactivity with recombinant mouse Mer is observed, and less than 0.3% cross-reactivity with recombinant human (rh) Axl is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Human Mer Fc Chimera (Catalog # 891-MR) |
| Human Mer Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human Mer Antibody (Catalog #MAB8912 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Human Mer Biotinylated Antibody (Catalog #BAF891 ) |
| ELISA Standard | Recombinant Human Mer Fc Chimera Protein, CF (Catalog #891-MR ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: Mer | Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Recent studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions. |
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References
| Nagata, K. et al. (1996) J. Biol. Chem. 22:30022. | |
| Crosier, K.E. and P.S Crosier (1997) Pathology 29:131. | |
| Long Name: | Receptor Tyrosine Protein Kinase Mer |
| Entrez Gene IDs: | 10461 (Human); 17289 (Mouse) |
| Alternate Names: | c-Eyk; c-mer proto-oncogene tyrosine kinase; C-mer; EC 2.7.10; EC 2.7.10.1; MER receptor tyrosine kinase; Mer; MerTK; MGC133349; Receptor tyrosine kinase MerTK; RP38Proto-oncogene c-Mer; STK kinase; tyrosine-protein kinase Mer |
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Related Research Areas
| Cancer Biomarkers | ||||||||
| Infectious Diseases | ||||||||
| Mouse Tissue-Resident Macrophage Markers | ||||||||
| Receptor Tyrosine Kinases (RTKs) | ||||||||
| Receptor Tyrosine Kinases (RTKs) in the Akt Pathway | ||||||||
| Receptors in the Jak/STAT Pathway | ||||||||
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| Images | Ratings | Applications | Species | Reviewed By | Date | Details | ||
|---|---|---|---|---|---|---|---|---|
| Very Good | ELISA | Human | Anonymous | 04/26/2017 | ||||
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Summary
| Application | ELISA | |||||||
| Sample Tested | A549 human lung carcinoma cell line | |||||||
| Species | Human | |||||||
| Excellent | ICC/IF | Human | Anonymous | 07/03/2016 |
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Summary
| Application | Immunocytochemistry/Immunofluorescence |
| Sample Tested | HUMAN MACROPHAGES |
| Species | Human |
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Related Product & Information
| Background | Mer |
|---|---|
| background_content | Background: Mer Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Recent studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions. |
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Citations
- IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids.
Authors: Zizzo G, Cohen P
J Immunol, 2013;190(10):5237-46.
Species: Human
Sample Type: Cell Lysates
Application: WB - Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.
Authors: Zizzo G, Hilliard B, Monestier M, Cohen P
J Immunol, 2012;189(7):3508-20.
Species: Human
Sample Type: Cell Lysates
Application: WB
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