抗Mouse IGF-I抗体(Anti-Mouse IGF-I antibody)
掲載日情報：2021/01/28 現在Webページ番号：29406
Mouse IGF-Iに対する抗体(Anti-Mouse IGF-I )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- Data Examples
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年05月14日 00時00分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-Mouse IGF-I/IGF-1 MAb (Clone 126002) |
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[在庫・価格 ：2025年05月14日 00時00分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-Mouse IGF-I/IGF-1 MAb (Clone 126002)
文献数： 0
- 商品コード：MAB791-100
- メーカー：RSD
- 包装：100μg
- 価格：¥101,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 別名：IBP1 クローン：126002 Genbank No： 3479 Protein Accession No： P05017 |
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| 別包装品 | 別包装品あり | ||||||
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| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Hamster | |||||
| 交差性 | Mouse | 適用 | ELISA,Neutralising,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | |||||||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Mouse IGF-I/IGF-1 MAb (Clone 126002)
文献数： 0
- 商品コード：MAB791-500
- メーカー：RSD
- 包装：500μg
- 価格：¥232,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Mouse IGF-I サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAF791，スタンダードとして#791-MG-050を用いる。 別名：IBP1 クローン：126002 Genbank No： 3479 Protein Accession No： P05017 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Hamster | |||||
| 交差性 | Mouse | 適用 | ELISA,Neutralising,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | |||||||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Mouse IGF-I/IGF-1 MAb (Clone 126002)
文献数： 0
- 商品コード：MAB791-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：IBP1 クローン：126002 Genbank No： 3479 Protein Accession No： P05017 |
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|---|---|---|---|---|---|---|---|
| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Hamster | |||||
| 交差性 | Mouse | 適用 | ELISA,Neutralising,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
|
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| 製品記事 | 使いっきり抗体 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Mouse |
|---|---|
| Label | Unconjugated |
| Immunogen | E. coli-derived recombinant mouse IGF-IGly49-Ala118Accession # P05017 |
| Source | Monoclonal Hamster IgG Clone # 126002 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects mouse IGF-I in direct ELISAs and Western blots. In ELISAs, this antibody does not cross-react with recombinant human (rh) IGF‑I, rmIGF-II, rmIGFBP-2, rmIGFBP-5, and rmIGFBP-6. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 1 µg/mL | Recombinant Mouse IGF-I (Catalog # 791-MG) |
| Mouse IGF-I Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Mouse IGF‑I Antibody (Catalog #MAB791 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse IGF‑I Biotinylated Antibody (Catalog #BAF791 ) |
| ELISA Standard | Recombinant Mouse IGF-I Protein, CF (Catalog #791-MG ) | |
| Neutralization | Measured by its ability to neutralize IGF‑I-induced proliferation in the MCF‑7 human breast cancer cell line. Karey, K.P. et al. (1988) Cancer Research 48:4083. The Neutralization Dose (ND50) is typically 0.3-1.5 µg/mL in the presence of 15 ng/mL Recombinant Mouse IGF‑I. | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | ||
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Data Examples
| Neutralization |
![Neutralization IGF-I Antibody (126002) [Unconjugated]](http://resources.rndsystems.com/images/datasheets/antibody/IGF-I_MAB791_Block_Neutralize_9277.jpg) click image to view larger | Cell Proliferation Induced by IGF‑I and Neutralization by Mouse IGF‑I Antibody.Recombinant Mouse IGF‑I (Catalog # 791-MG) stimulates proliferation in the MCF‑7 human breast cancer cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IGF‑I (15 ng/mL) is neutralized (green line) by increasing concentrations of Mouse IGF-I Monoclonal Antibody (Catalog # MAB791). The ND50 is typically 0.3-1.5 µg/mL. |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: IGF-I | Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-I is identical between isoforms and is generated by proteolytic removal of the N- and C-terminal regions. Mature mouse IGF-I shares 94% and 99% amino acid (aa) sequence identity with human and rat IGF-I, respectively (2), and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects (1). IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4-7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). IGF-I association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors (10). |
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References
| Philippou, A. et al. (2007) In Vivo 21:45. | |
| Bell, G.I. et al. (1986) Nucleic Acids Res. 14:7873. | |
| Guvakova, M.A. (2007) Int. J. Biochem. Cell Biol. 39:890. | |
| Clemmons, D.R. (2006) Curr. Opin. Pharmacol. 6:620. | |
| Bluher, S. et al. (2005) Best Pract. Res. Clin. Endocrinol. Metab. 19:577. | |
| Garcia-Segura, L.M. et al. (2006) Neuroendocrinology 84:275. | |
| Malemud, C.J. (2007) Clin. Chim. Acta 375:10. | |
| Samani, A.A. et al. (2007) Endocrine Rev. 28:20. | |
| LeRoith, D. and S. Yakar (2007) Nat. Clin. Pract. Endocrinol. Metab. 3:302. | |
| Denley, A. et al. (2005) Cytokine Growth Factor Rev. 16:421. | |
| Long Name: | Insulin-like Growth Factor I |
| Entrez Gene IDs: | 3479 (Human); 16000 (Mouse); 24482 (Rat) |
| Alternate Names: | IBP1; IGF1; IGF-1; IGF1A; IGFI; IGF-I; IGF-IA; IGF-IB; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; Mechano growth factor; MGF; Somatomedin A; Somatomedin C; somatomedin-C |
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Related Research Areas
| Alpha Granule Soluble Molecules | ||
| ALS Related Molecules | ||
| Cancer Biomarkers | ||
| Diabetes and Obesity Research | ||
| Endocrine Regulation of Lipid Metabolism | ||
| gamma delta T Cells | ||
| Glucose Homeostasis | ||
| IGF Family | ||
| IGF Ligands | ||
| Metabolic Peptide Hormones and Regulators | ||
| Preeclampsia | ||
| Protein/Peptide Hormones and Regulators | ||
| Reproduction | ||
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| Neutralization | |
|---|---|
 | Cell Proliferation Induced by IGF‑I and Neutralization by Mouse IGF‑I Antibody. Recombinant Mouse IGF‑I (Catalog # 791-MG) stimulates proliferation in the MCF‑7 human breast cancer cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IGF‑I (15 ng/mL) is neutralized (green line) by increasing concentrations of Mouse IGF-I Monoclonal Antibody (Catalog # MAB791). The ND50 is typically 0.3-1.5 µg/mL. |
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Related Product & Information
| Long Name | Insulin-like Growth Factor I |
|---|---|
| Entrez Gene IDs | 3479 (Human); 16000 (Mouse); 24482 (Rat) |
| Background | IGF-I |
| background_content | Background: IGF-I Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-I is identical between isoforms and is generated by proteolytic removal of the N- and C-terminal regions. Mature mouse IGF-I shares 94% and 99% amino acid (aa) sequence identity with human and rat IGF-I, respectively (2), and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects (1). IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4-7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). IGF-I association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors (10). |
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
- Insulin-like growth factor 1 is a direct HOXA9 target important for hematopoietic transformation.
Authors: Steger J, Fuller E, Garcia-Cuellar M, Hetzner K, Slany R
Leukemia, 2015;29(4):901-8.
Species: Mouse
Sample Type: Cell Culture Supernates
Application: ELISA Development - Spatial distribution of insulin-like growth factor binding protein-2 following hypoxic-ischemic injury.
Authors: Fletcher L, Isgor E, Sprague S, Williams L, Alajajian B, Jimenez D, Digicaylioglu M
BMC Neurosci, 2013;14(0):158.
Species: Mouse
Sample Type: Tissue Homogenates
Application: ELISA Capture - IGFBP-3 is a metastasis suppression gene in prostate cancer.
Authors: Mehta HH, Gao Q, Galet C
Cancer Res., 2011;71(15):5154-63.
Species: Mouse
Sample Type: Serum
Application: ELISA Development - Evidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation.
Authors: Yamada PM, Mehta HH, Hwang D
Endocrinology, 2010;151(12):5741-50.
Species: Mouse
Sample Type: Serum
Application: ELISA Development - Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model.
Authors: Raina K, Blouin MJ, Singh RP, Majeed N, Deep G, Varghese L, Glode LM, Greenberg NM, Hwang D, Cohen P, Pollak MN, Agarwal R
Cancer Res., 2007;67(22):11083-91.
Species: Mouse
Sample Type: Tissue Homogenates
Application: ELISA Development
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