抗Human BMP-7抗体(Anti-Human BMP-7 antibody)
掲載日情報：2021/01/28 現在Webページ番号：29346
Human BMP-7に対する抗体(Anti-Human BMP-7 )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- Data Examples
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年04月26日 20時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-Human BMP-7 MAb (Clone 164313) |
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[在庫・価格 ：2025年04月26日 20時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-Human BMP-7 MAb (Clone 164313)
文献数： 0
- 商品コード：MAB3542-100
- メーカー：RSD
- 包装：100μg
- 価格：¥99,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 別名：BMP7 クローン：164313 Genbank No： 655 Protein Accession No： P18075 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Mouse | |||||
| 交差性 | Human | 適用 | ELISA,IHC,Neutralising | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | |||||||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Human BMP-7 MAb (Clone 164313)
文献数： 0
- 商品コード：MAB3542-500
- メーカー：RSD
- 包装：500μg
- 価格：¥232,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human BMP-7 サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAM354，スタンダードとして#354-BP-010を用いる。 別名：BMP7 クローン：164313 Genbank No： 655 Protein Accession No： P18075 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Mouse | |||||
| 交差性 | Human | 適用 | ELISA,IHC,Neutralising | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | |||||||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Human BMP-7 MAb (Clone 164313)
文献数： 0
- 商品コード：MAB3542-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：BMP7 クローン：164313 Genbank No： 655 Protein Accession No： P18075 |
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|---|---|---|---|---|---|---|---|
| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Mouse | |||||
| 交差性 | Human | 適用 | ELISA,IHC,Neutralising | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | 使いっきり抗体 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human |
|---|---|
| Label | Unconjugated |
| Immunogen | Chinese hamster ovary cell line CHO-derived recombinant human BMP‑7Arg292-His431Accession # P18075 |
| Source | Monoclonal Mouse IgG1 Clone # 164313 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects human BMP-7 in ELISAs. In ELISAs, this antibody shows approximately 25-50% cross-reactivity with recombinant human (rh) BMP‑6 and no cross-reactivity with rhBMP-2, -3, -4, -5, or -8. |
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Applications and Data
| Recommended Concentration | Sample | |
| Immunohistochemistry | 8-25 µg/mL | See below |
| Human BMP-7 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human BMP‑7 Antibody (Catalog #MAB3542 ) |
| ELISA Detection (Matched Antibody Pair) | 0.5-2.0 µg/mL | Human BMP‑7 Biotinylated Antibody (Catalog #BAM354 ) |
| ELISA Standard | Recombinant Human BMP-7 Protein (Catalog #354-BP ) | |
| Neutralization | Measured by its ability to neutralize BMP‑7-induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. Erlacher, L. et al. (1998) J. Bone Miner. Res. 13:383. The Neutralization Dose (ND50) is typically 4-12 µg/mL in the presence of 1 µg/mL Recombinant Human BMP‑7 and 50 µg/mL L-ascorbic acid. | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | ||
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Data Examples
| Neutralization |
![Neutralization BMP-7 Antibody (164313) [Unconjugated]](http://resources.rndsystems.com/images/datasheets/antibody/BMP-7_MAB3542_Block_Neutralize_9160.jpg) click image to view larger | Alkaline Phosphatase Production Induced by BMP‑7 and Neutralization by Human BMP‑7 Antibody.Recombinant Human BMP‑7 (Catalog # 354-BP) induces alkaline phosphatase production in the the ATDC5 mouse chondrogenic cell line in a dose-dependent manner (orange line). Alkaline phosphatase production elicited by Recombinant Human BMP‑7 (1 µg/mL) is neutralized (green line) by increasing concentrations of Human BMP‑7 Monoclonal Antibody (Catalog # MAB3542). The ND50 is typically 4-12 µg/mL in the presence of L-ascorbic acid (50 µg/mL). |
| Immunohistochemistry |
![Immunohistochemistry BMP-7 Antibody (164313) [Unconjugated]](http://resources.rndsystems.com/images/datasheets/antibody/BMP-7_MAB3542_Immunohistochemistry_6999.jpg) click image to view larger | BMP‑7 in Human Prostate Cancer Tissue.BMP‑7 was detected in immersion fixed paraffin-embedded sections of human prostate cancer tissue using 25 µg/mL Human BMP‑7 Monoclonal Antibody (Catalog # MAB3542) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections. |
| Immunohistochemistry |
![Immunohistochemistry BMP-7 Antibody (164313) [Unconjugated]](http://resources.rndsystems.com/images/datasheets/antibody/BMP-7_MAB3542_Immunohistochemistry_9705.jpg) click image to view larger | BMP‑7 in Human Prostate.BMP‑7 was detected in immersion fixed paraffin-embedded sections of human prostate using Human BMP‑7 Monoclonal Antibody (Catalog # MAB3542) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections. |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: BMP-7 | BMP-7, or osteogenic protein 1 (OP-1), is one of at least 15structurally and functionally related BMPs, which are members of thetransforming growth factor beta (TGF-beta ) superfamily. BMPs regulatecartilage and bone formation, embryogenesis and morphogenesis ofvarious tissues and organs, and growth, differentiation, chemotaxis andapoptosis of various cell types. Biologically active BMP-7 is adisulfide-linked homodimer. Cellular responses to BMP-7 have been shownto be mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. | |
| Long Name: | Bone Morphogenetic Protein 7 | |
| Entrez Gene IDs: | 655 (Human); 12162 (Mouse); 85272 (Rat) | |
| Alternate Names: | BMP7; BMP-7; bone morphogenetic protein 7; Eptotermin alfa; OP-1; OP-1OP1; Osteogenic protein 1 | |
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Related Research Areas
| BMP Family | ||
| BMPs (Bone Morphogenetic Proteins) | ||
| Early Mesodermal Lineage Markers | ||
| Mesenchymal to Epithelial Transition | ||
| Negative Regulators of EMT | ||
| Neural Crest Cell Markers | ||
| TGF-beta Superfamily | ||
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| Neutralization | |
|---|---|
 | Alkaline Phosphatase Production Induced by BMP‑7 and Neutralization by Human BMP‑7 Antibody. Recombinant Human BMP‑7 (Catalog # 354-BP) induces alkaline phosphatase production in the the ATDC5 mouse chondrogenic cell line in a dose-dependent manner (orange line). Alkaline phosphatase production elicited by Recombinant Human BMP‑7 (1 µg/mL) is neutralized (green line) by increasing concentrations of Human BMP‑7 Monoclonal Antibody (Catalog # MAB3542). The ND50 is typically 4-12 µg/mL in the presence of L-ascorbic acid (50 µg/mL). |
| Immunohistochemistry | |
 | BMP‑7 in Human Prostate Cancer Tissue. BMP‑7 was detected in immersion fixed paraffin-embedded sections of human prostate cancer tissue using 25 µg/mL Human BMP‑7 Monoclonal Antibody (Catalog # MAB3542) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections. |
| Immunohistochemistry | |
 | BMP‑7 in Human Prostate. BMP‑7 was detected in immersion fixed paraffin-embedded sections of human prostate using Human BMP‑7 Monoclonal Antibody (Catalog # MAB3542) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections. |
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Related Product & Information
| Long Name | Bone Morphogenetic Protein 7 |
|---|---|
| Entrez Gene IDs | 655 (Human); 12162 (Mouse); 85272 (Rat) |
| Background | BMP-7 |
| background_content | Background: BMP-7 BMP-7, or osteogenic protein 1 (OP-1), is one of at least 15structurally and functionally related BMPs, which are members of thetransforming growth factor beta (TGF-beta ) superfamily. BMPs regulatecartilage and bone formation, embryogenesis and morphogenesis ofvarious tissues and organs, and growth, differentiation, chemotaxis andapoptosis of various cell types. Biologically active BMP-7 is adisulfide-linked homodimer. Cellular responses to BMP-7 have been shownto be mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. |
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products.The data collected includes not only links to publications in PubMed,but also provides information about sample types, species, and experimental conditions.
- Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism.
Authors: Dai J, Keller J, Zhang J, Lu Y, Yao Z, Keller ET
Cancer Res., 2005;65(18):8274-85.
Species: Human
Sample Type: Cell Lysates
Application: WB
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