抗Human BMP-2抗体(Anti-Human BMP-2 antibody)

• 価格
• Product Details
• Applications and Data
• Related Research Areas
• Related Product & Information
• Citations

価格

目次に戻る

Product Details

Species Reactivity	Human
Label	Unconjugated
Immunogen	Chinese hamster ovary cell line CHO-derived recombinant human BMP-2Gln283-Arg396Accession # P12643
Source	Monoclonal Mouse IgG2B Clone # 100221
Purification	Protein A or G purified from ascites
Specificity	Detects human BMP-2 in ELISAs and Western blots. In Western blots, this antibody shows less than 1% cross-reactivity with recombinant human (rh) BMP‑3, rhBMP-4, rhBMP-5, rhBMP-6, or rhBMP-7.

目次に戻る

Applications and Data

	Recommended Concentration	Sample
Western Blot	1 µg/mL	Recombinant Human BMP‑2 (Catalog # 355-BM)
Human BMP-2 Sandwich Immunoassay	Reagent
ELISA Capture (Matched Antibody Pair)	2-8 µg/mL	Human BMP‑2 Antibody (Catalog #MAB3551 )
ELISA Detection (Matched Antibody Pair)	0.5-2.0 µg/mL	Human BMP‑2 Biotinylated Antibody (Catalog #BAM3552 )
ELISA Standard		Recombinant Human/Mouse/Rat BMP-2 Protein (Catalog #355-BM )
Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website.		Preparation and Storage
Reconstitution	Reconstitute at 0.5 mg/mL in sterile PBS.	Reconstitution Buffer Available
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: BMP-2	BMP-2 is one of at least 15 structurally and functionally related BMPs,which are members of the transforming growth factor beta (TGF-beta )superfamily, BMPs were originally identified as protein regulators ofcartilage and bone formation. However, they have since been shown to beinvolved in embryogenesis and morphogenesis of various tissues andorgans.
Long Name:	Bone Morphogenetic Protein 2
Entrez Gene IDs:	650 (Human); 12156 (Mouse); 29373 (Rat)
Alternate Names:	BMP2; BMP-2; BMP-2A; BMP2ABone morphogenetic protein 2A; bone morphogenetic protein 2

目次に戻る

Related Research Areas

BMP Family

BMPs (Bone Morphogenetic Proteins)

BMPs and Regulators Secreted by Endothelial Cells

Early Mesodermal Lineage Markers

EMT Induction

Mesenchymal to Epithelial Transition

Molecules Secreted by VSMC

TGF-beta Superfamily

TNF? drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling Authors: LA Hurst, BJ Dunmore, L Long, A Crosby, R Al-Lamki, J Deighton, M Southwood, X Yang, MZ Nikolic, B Herrera, GJ Inman, JR Bradley, AA Rana, PD Upton, NW Morrell Nat Commun, 2017;8(0):14079. Species: Mouse Sample Type: Whole Cells Application: Neut

目次に戻る

Related Product & Information

Background	BMP-2
background_content	Background: BMP-2 BMP-2 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor beta (TGF-beta ) superfamily, BMPs were originally identified as protein regulators of cartilage and bone formation. However, they have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs.

目次に戻る

Citations

1. TNF? drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling
   Authors: LA Hurst, BJ Dunmore, L Long, A Crosby, R Al-Lamki, J Deighton, M Southwood, X Yang, MZ Nikolic, B Herrera, GJ Inman, JR Bradley, AA Rana, PD Upton, NW Morrell
   Nat Commun, 2017;8(0):14079.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Neut


2. Osteogenic Surface Modification Based on Functionalized Poly-P-Xylylene Coating.
   Authors: Chang C, Yeh S, Lee B, Chen C, Su C, Lin Y, Liu C, Chen H
   PLoS ONE, 2015;10(9):e0137017.
   Species: Human
   Sample Type: Recombinant Protein
   Application: Bioassay


3. Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade.
   Authors: Du Y, Xiao Q, Yip HK
   Invest. Ophthalmol. Vis. Sci., 2010;51(7):3764-73.
   Species: Mouse
   Sample Type: Tissue Homogenates
   Application: WB


4. Periodontal regeneration using ex vivo autologous stem cells engineered to express the BMP-2 gene: an alternative to alveolaplasty.
   Authors: Chen YL, Chen PK, Jeng LB, Huang CS, Yang LC, Chung HY, Chang SC
   Gene Ther., 2008;15(22):1469-77.
   Species: Rabbit
   Sample Type: Cell Lysates
   Application: WB


5. Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.
   Authors: Kuns-Hashimoto R, Kuninger D, Nili M, Rotwein P
   Am. J. Physiol., Cell Physiol., 2008;294(4):C994-C1003.
   Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
   Sample Type: Cell Culture Supernates
   Application: IP


6. Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis.
   Authors: Kane R, Godson C, O'Brien C
   Mol. Vis., 2008;14(0):1138-48.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


7. Targeting of bone morphogenetic protein growth factor complexes to fibrillin.
   Authors: Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bachinger HP, Sakai LY
   J. Biol. Chem., 2008;283(20):13874-88.
   Species: Human
   Sample Type: Recombinant Protein
   Application: WB


8. Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism.
   Authors: Dai J, Keller J, Zhang J, Lu Y, Yao Z, Keller ET
   Cancer Res., 2005;65(18):8274-85.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


9. Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer.
   Authors: Kayed H, Kleeff J, Keleg S, Guo J, Ketterer K, Berberat P, Giese N, Esposito I, Giese T, Buchler M, Friess H
   Int J Cancer, 2004;110(5):668-76.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB

目次に戻る