抗Galectin-7抗体(Anti-Galectin-7, Mouse, Rat-Mono antibody)
掲載日情報:2021/01/28 現在Webページ番号:29286
Galectin-7に対する抗体(Anti-Galectin-7, Mouse, Rat-Mono )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- Data Examples
- References
- Related Research Areas
- Summary
- Related Product & Information
価格
[在庫・価格 :2024年05月07日 18時55分現在]
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Anti-Galectin-7, Mouse, Rat-Mono(212923) |
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Anti-Mouse Galectin-7 MAb (Clone 212923) |
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[在庫・価格 :2024年05月07日 18時55分現在]
Anti-Galectin-7, Mouse, Rat-Mono(212923)
文献数: 0
- 商品コード:MAB1304
- メーカー:RSD
- 包装:500μg
- 価格:¥121,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 |
マッチドペア:Mouse Galectin-7 サンドイッチELISAの補足用抗体として利用可能,検出用抗体として#BAF1304,スタンダードとして#1304-GA-050を用いる。 別名:Gal-7 クローン:212923 Genbank No: 3963 Protein Accession No: AAK29385 |
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別包装品 | 別包装品あり | ||||||
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保存条件 | -20℃ | 法規備考 | |||||
抗原種 | Mouse | 免疫動物 | Rat | ||||
交差性 | Mouse | 適用 | ELISA,IHC,Western Blot | ||||
標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Monoclonal | フォーマット | |||||
掲載カタログ |
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製品記事 |
R&D Systems社のGalectin-7関連製品 |
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関連記事 |
R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
Anti-Mouse Galectin-7 MAb (Clone 212923)
文献数: 0
- 商品コード:MAB1304-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥30,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 |
※受注発注品。形状:溶液または凍結乾燥 別名:Gal-7 クローン:212923 Genbank No: 3963 Protein Accession No: AAK29385 |
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別包装品 | 別包装品あり | ||||||
法規制等 | |||||||
保存条件 | -20℃ | 法規備考 | |||||
抗原種 | 免疫動物 | Rat | |||||
交差性 | Mouse | 適用 | ELISA,IHC,Western Blot | ||||
標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Monoclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | |||||||
関連記事 |
R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
Species Reactivity | Mouse |
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Label | Unconjugated |
Immunogen | E. coli-derived recombinant mouse Galectin‑7Ser2-Phe136Accession # AAK29385 |
Source | Monoclonal Rat IgG2A Clone # 212923 |
Purification | Protein A or G purified from hybridoma culture supernatant |
Specificity | Detects mouse Galectin-7 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse Galectin‑1, ‑3, ‑4, recombinant human (rh) Galectin-2, -7, or -8 is observed. In Western blots, approximately 20% cross-reactivity with rhGalectin‑3, approximately 10% cross-reactivity with rhGalectin-7, and no cross-reactivity with rhGalectin-1 is observed. |
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Applications and Data
Recommended Concentration | Sample | |
Western Blot | 1 µg/mL | Recombinant Mouse Galectin‑7 (Catalog # 1304-GA) |
Immunohistochemistry | 8-25 µg/mL | See below |
Mouse Galectin-7 Sandwich Immunoassay | Reagent | |
ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Mouse Galectin‑7 Antibody (Catalog #MAB1304 ) |
ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse Galectin‑7 Biotinylated Antibody (Catalog #BAF1304 ) |
ELISA Standard | Recombinant Mouse Galectin-7 Protein (Catalog #1304-GA ) | |
Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. |
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Data Examples
Immunohistochemistry |
click image to view larger | Galectin‑7 in Mouse Thymus. Galectin‑7 was detected in perfusion fixed frozen sections of mouse thymus using Rat Anti-Mouse Galectin‑7 Monoclonal Antibody (Catalog # MAB1304) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS017) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of lymphocytes. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections. |
Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
Background: Galectin-7 | The galectins constitute a large family of carbohydrate-binding proteins with specificity for N-acetyl-lactosamine-containing glycoproteins. At least 14 mammalian galectins, which share structural similarities in their carbohydrate recognition domains (CRD), have been identified. The galectins have been classified into the prototype galectins (-1, -2, -5, -7, -10, -11, -13, -14), which contain one CRD and exist either as a monomer or a noncovalent homodimer; the chimera galectins (Galectin-3) containing one CRD linked to a nonlectin domain; and the tandem-repeat galectins (-4, -6, -8, -9, -12) consisting of two CRDs joined by a linker peptide. Galectins lack a classical signal peptide and can be localized to the cytosolic compartments where they have intracellular functions. However, via one or more as yet unidentified non-classical secretory pathways, galectins can also be secreted to function extracellularly. Individual members of the galectin family have different tissue distribution profiles and exhibit subtle differences in their carbohydrate-binding specificities. Each family member may preferentially bind to a unique subset of cell-surface glycoproteins (1‑4). Mouse Galectin-7 is a prototype monomeric galectin. It is expressed in stratified epithelia and is significantly down-regulated in squamous cell carcinomas. Galectin-7 is a pro-apoptotic protein that is highly induced by the tumor suppressor protein p53. It functions intracellularly upstream of JNK activation to enhance cytochrome c release during apoptosis (5). Galectin-7 may also be involved in cell-cell and cell-matrix interactions and exogenous galectin has been found to accelerate the re‑epithelialization of wounds (6). |
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References
Rabinovich, A. et al. (2002) TRENDS in Immunol. 23:313. | |
Rabinovich, A. et al. (2002) J. Leukocyte Biology 71:741. | |
Hughes, R.C. (2002) Biochimie 83:667. | |
R&D Systems' Cytokine Bulletin, Summer (2002). | |
Kuwabara, I. et al. (2002) J. Biol. Chem. 277:3487. | |
Cao, Z. et al. (2002) J. Biol. Chem. 277:42299. | |
Entrez Gene IDs: | 3963 (Human); 16858 (Mouse) |
Alternate Names: | GAL7; Gal-7; galectin 7; Galectin7; Galectin-7; HKL-14; lectin, galactoside-binding, soluble, 7; LGALS7; LGALS7A; p53-induced gene 1 protein; PI7; PIG1; TP53I1 |
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Related Research Areas
Galectins | ||||||||||
Lectins | ||||||||||
Images | Ratings | Applications | Species | Reviewed By | Date | Details | ||||
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Enlarge | Excellent | IHC | Human | Anonymous | 10/26/2015 | Image Details |
Immunohistochemistry: Mouse Galectin‑7 Antibody [MAB1304]. |
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Summary
Application | Immunohistochemistry |
Sample Tested | Human tissue |
Species | Human |
Other Experimental Details | This version of antibody is very specific and works well at 1:500 dilution and is almost equal to polyclonal version. Specificity: Specific Sensitivity: Sensitive Buffer: PBS Dilution: 1:500 |
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Related Product & Information
Background | Galectin-7 |
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background_content | Background: Galectin-7 The galectins constitute a large family of carbohydrate-binding proteins with specificity for N-acetyl-lactosamine-containing glycoproteins. At least 14 mammalian galectins, which share structural similarities in their carbohydrate recognition domains (CRD), have been identified. The galectins have been classified into the prototype galectins (-1, -2, -5, -7, -10, -11, -13, -14), which contain one CRD and exist either as a monomer or a noncovalent homodimer; the chimera galectins (Galectin-3) containing one CRD linked to a nonlectin domain; and the tandem-repeat galectins (-4, -6, -8, -9, -12) consisting of two CRDs joined by a linker peptide. Galectins lack a classical signal peptide and can be localized to the cytosolic compartments where they have intracellular functions. However, via one or more as yet unidentified non-classical secretory pathways, galectins can also be secreted to function extracellularly. Individual members of the galectin family have different tissue distribution profiles and exhibit subtle differences in their carbohydrate-binding specificities. Each family member may preferentially bind to a unique subset of cell-surface glycoproteins (1‑4). Mouse Galectin-7 is a prototype monomeric galectin. It is expressed in stratified epithelia and is significantly down-regulated in squamous cell carcinomas. Galectin-7 is a pro-apoptotic protein that is highly induced by the tumor suppressor protein p53. It functions intracellularly upstream of JNK activation to enhance cytochrome c release during apoptosis (5). Galectin-7 may also be involved in cell-cell and cell-matrix interactions and exogenous galectin has been found to accelerate the re‑epithelialization of wounds (6). |
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