抗Human CXCR4 Phycoerythrin抗体(Anti-Human CXCR4 Phycoerythrin antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Phycoerythrin
Immunogen	Mouse 3T3 cells transfected with human CXCR4
Source	Monoclonal Mouse IgG2B Clone # 44717
Purification	Protein A or G purified from ascites
Specificity	Reacts specifically with human and non-human cells expressing human CXCR4 (fusin) as detected by flow cytometry. It will also react with cells expressing feline CXCR4 but not rat CXCR4. This antibody does not cross-react with other chemokine receptors.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry
	Detection of CXCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CXCR4 PE‑conjugated Monoclonal Antibody (Catalog # FAB173P) and Mouse Anti-Human CD19 APC‑conjugated Monoclonal Antibody (Catalog # FAB4867A). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Entrez Gene IDs	7852 (Human); 12767 (Mouse); 60628 (Rat); 483900 (Canine); 493676 (Feline)
Background	CXCR4
background_content	Background: CXCR4 CXCR4 is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and -2 viral entry into cells.

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Citations

1. A human immunodeficiency syndrome caused by mutations in CARMIL2
   Authors: T Schober, T Magg, M Laschinger, M Rohlfs, ND Linhares, J Puchalka, T Weisser, K Fehlner, J Mautner, C Walz, K Hussein, G Jaeger, B Kammer, I Schmid, M Bahia, SD Pena, U Behrends, BH Belohradsk, C Klein, F Hauck
   Nat Commun, 2017;8(0):14209.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. CXCR4/IgG-expressing plasma cells are associated with human gastrointestinal tissue inflammation.
   Authors: Buckner, Clarisa, Moir, Susan, Kardava, Lela, Ho, Jason, Santich, Brian H, Kim, Leo Jin, Funk, Emily K, Nelson, Amy K, Winckler, Britanny, Chairez, Cheryl L, Theobald-Whiting, Narda L, Anaya-O'Brien, Sandra, Alimchandani, Meghna, Quezado, Martha M, Yao, Michael, Kovacs, Joseph A, Chun, Tae-Wook, Fauci, Anthony, Malech, Harry L, De Ravin, Suk See
   J Allergy Clin Immunol, 2014;133(6):1676-85.e5.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


3. Expression and functional heterogeneity of chemokine receptors CXCR4 and CXCR7 in primary patient-derived glioblastoma cells.
   Authors: Liu, Che, Pham, Kien, Luo, Defang, Reynolds, Brent A, Hothi, Parvinde, Foltz, Gregory, Harrison, Jeffrey
   PLoS ONE, 2013;8(3):e59750.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


4. Protein kinase C and NF-kappaB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.
   Authors: Raposo RA, Trudgian DC, Thomas B, van Wilgenburg B, Cowley SA, James W
   J. Immunol., 2011;187(2):748-59.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


5. Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.
   Authors: Badr G, Lefevre EA, Mohany M
   PLoS ONE, 2011;6(9):e23741.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


6. Human melanoma metastases express functional CXCR4.
   Authors: Scala S, Giuliano P, Ascierto PA, Ierano C, Franco R, Napolitano M, Ottaiano A, Lombardi ML, Luongo M, Simeone E, Castiglia D, Mauro F, De Michele I, Calemma R, Botti G, Caraco C, Nicoletti G, Satriano RA, Castello G
   Clin. Cancer Res., 2006;12(8):2427-33.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


7. Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry.
   Authors: Hatse S, Princen K, Vermeire K, Gerlach LO, Rosenkilde MM, Schwartz TW, Bridger G, De Clercq E, Schols D
   FEBS Lett., 2003;546(2):300-6.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


8. Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.
   Authors: Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A
   J. Leukoc. Biol., 2003;73(5):584-90.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


9. Clonal Th2 cells associated with chronic hypereosinophilia: TARC-induced CCR4 down-regulation in vivo.
   Authors: de Lavareille A, Roufosse F, Schandene L, Stordeur P, Cogan E, Goldman M
   Eur. J. Immunol., 2001;31(4):1037-46.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow

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