抗CXCL5抗体(Anti-CXCL5, Human, Goat-Poly, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：29090
CXCL5に対する抗体(Anti-CXCL5, Human, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年04月26日 20時55分現在]
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Anti-CXCL5, Human, Goat-Poly, Biotin <Anti-ENA-78> |
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[在庫・価格 ：2025年04月26日 20時55分現在]
Anti-CXCL5, Human, Goat-Poly, Biotin <Anti-ENA-78>
文献数： 3
- 商品コード：BAF254
- メーカー：RSD
- 包装：50μg
- 価格：¥119,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human CXCL5/ENA-78 サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB654-500，スタンダードとして#254-XB-025を用いる。 別名：CXCL5，ENA-78 Genbank No： 6374 Protein Accession No： P42830 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Human | 免疫動物 | Goat |
| 交差性 | Human | 適用 | ELISA,Western Blot |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | M1/M2 Macrophage Activation Marker |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human |
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| Label | Biotin |
| Immunogen | E. coli-derived recombinant human CXCL5/ENA-78Ala37-Asn114Accession # P42830 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects human ENA-78 in ELISAs and Western blots. In sandwich immunoassays, less than 0.2% cross-reactivity with rhGCP-2 is observed and less than 0.05% cross-reactivity with rmGCP-2, rhGRO alpha, rrCINC-1, rmKC, rhNAP-2 and rhIL-8 is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Human CXCL5/ENA‑78 (Catalog # 254-XB) |
| Human CXCL5/ENA-78 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human CXCL5/ENA‑78 Antibody (Catalog #MAB654 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Human CXCL5/ENA‑78 Biotinylated Antibody (Catalog #BAF254 ) |
| ELISA Standard | Recombinant Human CXCL5/ENA-78 Protein (Catalog #254-XB ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: CXCL5/ENA-78 | CXCL5, also known as epithelial cell-derived neutrophil-activating peptide (ENA-78), is an 8 kDa proinflammatory member of the CXC subfamily of chemokines. Its Glu-Leu-Arg (ELR) motif confers angiogenic properties and distinguishes it from ELR-CXC chemokines which are angiostatic (1 - 3). Human CXCL5 shares 57% amino acid (aa) sequence identity with mouse and rat CXCL5. Among other human ELR+ chemokines, it shares 77% aa sequence identity with CXCL6/GCP-2 and 35% - 51% with CXCL1/GRO alpha, CXCL2/GRO beta, CXCL3/GRO gamma, CXCL7/NAP-2, and CXCL8/IL-8. Inflammatory stimulation upregulates CXCL5 production in multiple hematopoietic cell types, fibroblasts, endothelial cells, and vascular smooth muscle cells. In vivo, CXCL5 is elevated at sites of inflammation and pulmonary fibrosis where it promotes neutrophil infiltration and activation as well as angiogenesis (3 - 6). Its upregulation contributes to increased vascularization, tumor growth, and metastasis in many cancers (6 - 9). Full length CXCL5 (78 aa) is trimmed at the N-terminus by cathepsin G and chymotrypsin to ENA-74 (74 aa) and ENA-70 (70 aa), with the shortened forms showing increased potency relative to full length CXCL5 (10, 11). CXCL5 exerts its effects primarily through interactions with CXCR2 (6, 12). It also binds duffy antigen receptor for chemokines (DARC), which can limit CXCR2-mediated responses (13, 14). |
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References
| Strieter, R.M. et al. (2005) Cytokine Growth Factor Rev. 16:593. | |
| Balestrieri, M.L. et al. (2008) Cardiovasc. Res. 78:250. | |
| Walz, A.. et al. (1991) J. Exp. Med. 174:1355. | |
| Strieter, R.M. et al. (1992) Immunol. Invest. 21:549. | |
| Koch, A.E. et al. (1994) J. Clin. Invest. 94:1012. | |
| Begley, L.A. et al. (2008) Neoplasia 10:244. | |
| Vandercappellen, J. et al. (2008) Cancer Lett. 267:226. | |
| Arenberg, D.A. et al. (1998) J. Clin. Invest. 102:465. | |
| Miyazaki, H. et al. (2006) Cancer Res. 66:4279. | |
| Wuyts, A. et al. (1999) Eur. J. Biochem. 260:421. | |
| Nufer, O. et al. (1999) Biochemistry 38:636. | |
| Ahuja, S.K. and P.M. Murphy (1996) J. Biol. Chem. 271:20545. | |
| Kashiwazaki, M. et al. (2003) Int. Immunol. 15:1219. | |
| Horton, L.W. et al. (2007) Cancer Res. 67:9791. | |
| Entrez Gene IDs: | 6374 (Human) |
| Alternate Names: | CXCL5; CXCL5/ENA-78; ENA78; ENA-78 |
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Related Research Areas
| Alpha Granule Soluble Molecules | ||
| Chemokines and Receptors | ||
| Chemokines and Receptors in Angiogenesis | ||
| CXC Chemokines and Receptors | ||
| Macrophage Activation Markers | ||
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Related Product & Information
| Background | CXCL5/ENA-78 |
|---|---|
| background_content | Background: CXCL5/ENA-78 CXCL5, also known as epithelial cell-derived neutrophil-activating peptide (ENA-78), is an 8 kDa proinflammatory member of the CXC subfamily of chemokines. Its Glu-Leu-Arg (ELR) motif confers angiogenic properties and distinguishes it from ELR-CXC chemokines which are angiostatic (1 - 3). Human CXCL5 shares 57% amino acid (aa) sequence identity with mouse and rat CXCL5. Among other human ELR+ chemokines, it shares 77% aa sequence identity with CXCL6/GCP-2 and 35% - 51% with CXCL1/GRO alpha, CXCL2/GRO beta, CXCL3/GRO gamma, CXCL7/NAP-2, and CXCL8/IL-8. Inflammatory stimulation upregulates CXCL5 production in multiple hematopoietic cell types, fibroblasts, endothelial cells, and vascular smooth muscle cells. In vivo, CXCL5 is elevated at sites of inflammation and pulmonary fibrosis where it promotes neutrophil infiltration and activation as well as angiogenesis (3 - 6). Its upregulation contributes to increased vascularization, tumor growth, and metastasis in many cancers (6 - 9). Full length CXCL5 (78 aa) is trimmed at the N-terminus by cathepsin G and chymotrypsin to ENA-74 (74 aa) and ENA-70 (70 aa), with the shortened forms showing increased potency relative to full length CXCL5 (10, 11). CXCL5 exerts its effects primarily through interactions with CXCR2 (6, 12). It also binds duffy antigen receptor for chemokines (DARC), which can limit CXCR2-mediated responses (13, 14). |
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Citations
- Combination therapy: Synergistic suppression of virus-induced chemokines in airway epithelial cells.
Authors: Edwards MR, Johnson MW, Johnston SL
Am. J. Respir. Cell Mol. Biol., 2006;34(5):616-24.
Species: Human
Sample Type: Cell Culture Supernates
Application: ELISA Development - Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angiogenic activity and procollagen levels in acute respiratory distress syndrome.
Authors: Keane MP, Donnelly SC, Belperio JA, Goodman RB, Dy M, Burdick MD, Fishbein MC, Strieter RM
J. Immunol., 2002;169(11):6515-21.
Species: Human
Sample Type: BALF
Application: ELISA Development
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