抗ICAM-1抗体(Anti-ICAM-1, Human, Goat-Poly antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Unconjugated
Immunogen	Chinese hamster ovary cell line CHO-derived recombinant human ICAM‑1/CD54Extracellular domain
Source	Polyclonal Goat Serum
Purification	N/A
Specificity	Detects human ICAM‑1/CD54 in direct ELISAs and Western blots. ICAM‑1/CD54 has been screened using CHO cells transfected with cDNAs for ICAM-1, VCAM-1, and E-Selectin. ICAM‑1/CD54 was shown to be only reactive with ICAM-1.

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Applications and Data

	Recommended Concentration	Sample
Western Blot	1:1000 dilution	Recombinant Human ICAM‑1/CD54 Fc Chimera (Catalog # 720-IC)
Immunohistochemistry	1:300 dilution	Immersion fixed paraffin-embedded sections of human kidney

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Related Product & Information

Background

ICAM-1/CD54

background_content

Background: ICAM-1/CD54 Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac-1. ICAM-1 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma, TNF-alpha, IL-1 beta and LPS. Soluble ICAM-1 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and transplantation.

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Citations

1. Amyloid-beta 1-40 is associated with alterations in NG2+ pericyte population ex�vivo and in�vitro
   Authors: N Schultz, K Brännström, E Byman, S Moussaud, HM Nielsen,, A Olofsson, M Wennström
   Aging Cell, 2018;0(0):.
   Species: Human
   Sample Type: Whole Tissue
   Application: IHC-F


2. Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-kappaB-dependent phases.
   Authors: Clark P, Kim R, Pober J, Kluger M
   PLoS ONE, 2015;10(3):e0120075.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


3. Outer membrane vesicles derived from Escherichia coli up-regulate expression of endothelial cell adhesion molecules in vitro and in vivo.
   Authors: Kim J, Yoon Y, Lee J, Choi E, Yi N, Park K, Park J, Lotvall J, Kim Y, Gho Y
   PLoS ONE, 2013;8(3):e59276.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


4. Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers.
   Authors: van Grevenstein WM, Hofland LJ, van Rossen ME, van Koetsveld PM, Jeekel J, van Eijck CH
   Dig. Dis. Sci., 2007;52(10):2775-83.
   Species: Human
   Sample Type: Whole Cells
   Application: ICC


5. Endothelial adhesion molecule expression is unaltered in the peripheral nerve from patients with AIDS and distal sensory polyneuropathy.
   Authors: Fenzi F, Rossi F, Rava M, Cavallaro T, Ferrari S, Rizzuto N
   J. Neuroimmunol., 2006;178(1):111-6.
   Species: Human
   Sample Type: Whole Tissue
   Application: IHC Paraffin-embedded


6. Requirement for intercellular adhesion molecule 1 and caveolae in invasion of human oral epithelial cells by Porphyromonas gingivalis.
   Authors: Tamai R, Asai Y, Ogawa T
   Infect. Immun., 2005;73(10):6290-8.
   Species: Human
   Sample Type: Whole Cells
   Application: Neut


7. TNFalpha increases the inflammatory response to vascular balloon injury without accelerating neointimal formation.
   Authors: Miller AM, McPhaden AR, Preston A, Wadsworth RM, Wainwright CL
   Atherosclerosis, 2005;179(1):51-9.
   Species: Rabbit
   Sample Type: Whole Tissue
   Application: IHC Paraffin-embedded


8. E-selectin and ICAM-1 are incorporated into detergent-insoluble membrane domains following clustering in endothelial cells.
   Authors: Tilghman RW, Hoover RL
   FEBS Lett., 2002;525(1):83-7.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB

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