抗GM-CSF抗体(Anti-GM-CSF, Mouse, Goat-Poly antibody)
掲載日情報:2019/10/21 現在Webページ番号:28895
GM-CSFに対する抗体(Anti-GM-CSF, Mouse, Goat-Poly )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2025年04月26日 20時55分現在]
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Anti-GM-CSF, Mouse, Goat-Poly |
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Anti-Mouse GM-CSF Affinity Purified Polyclonal Ab |
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[在庫・価格 :2025年04月26日 20時55分現在]
Anti-GM-CSF, Mouse, Goat-Poly
文献数: 11
- 商品コード:AF-415-NA
- メーカー:RSD
- 包装:100μg
- 価格:¥101,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 別名:colony stimulating factor 2 (granulocyte-macrophage) Genbank No: 1437 Protein Accession No: Q14AD9 |
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別包装品 | 別包装品あり | ||||||
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保存条件 | -20℃ | 法規備考 | |||||
抗原種 | Mouse | 免疫動物 | Goat | ||||
交差性 | Mouse | 適用 | Neutralising,Western Blot | ||||
標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Polyclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | M1/M2 Macrophage Activation Marker 抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社) |
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関連記事 |
Anti-Mouse GM-CSF Affinity Purified Polyclonal Ab
文献数: 0
- 商品コード:AF-415-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥30,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | ※受注発注品。形状:溶液または凍結乾燥 別名:colony stimulating factor 2 (granulocyte-macrophage) Genbank No: 1437 Protein Accession No: Q14AD9 |
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別包装品 | 別包装品あり | ||||||
法規制等 | |||||||
保存条件 | -20℃ | 法規備考 | |||||
抗原種 | 免疫動物 | Goat | |||||
交差性 | Mouse | 適用 | Neutralising,Western Blot | ||||
標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Polyclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | M1/M2 Macrophage Activation Marker 抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社) 使いっきり抗体 |
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関連記事 |
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Product Details
Species Reactivity | Mouse |
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Label | Unconjugated |
Immunogen | E. coli-derived recombinant mouse GM-CSFAla18-Lys141Accession # Q14AD9 |
Source | Polyclonal Goat IgG |
Purification | Antigen Affinity-purified |
Specificity | Detects mouse GM-CSF in direct ELISAs and Western blots. In direct ELISAs, approximately 30% cross‑reactivity with recombinant rat GM‑CSF is observed, approximately 10% cross-reactivity with recombinant human GM‑CSF and recombinant feline GM‑CSF is observed, and less than 2% cross‑reactivity with recombinant porcine GM‑CSF is observed. |
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Applications and Data
Recommended Concentration | Sample | |
Western Blot | 0.1 µg/mL | Recombinant Mouse GM-CSF (Catalog # 415-ML) |
Neutralization | Measured by its ability to neutralize GM‑CSF-induced proliferation in the DA3 mouse myeloma cell line. Ihle, J.N. et al. (1984) Advances in Viral Oncology. In G. Klein (eds): Raven Press, New York, NY. 4:95. The Neutralization Dose (ND50) is typically 0.01-0.03 µg/mL in the presence of 0.75 ng/mL Recombinant Mouse GM‑CSF. |
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Related Product & Information
Long Name | Granulocyte Macrophage Growth Factor |
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Entrez Gene IDs | 1437 (Human); 12981 (Mouse); 116630 (Rat); 397208 (Porcine); 403923 (Canine); 493805 (Feline) |
Background | GM-CSF |
background_content | Background: GM-CSF GM-CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM-CSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils. GM-CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity. It shows clinical effectiveness in ameliorating chemotherapy-induced neutropenia, and GM-CSF transfected tumor cells are utilized as cancer vaccines. The 22 kDa glycosylated GM-CSF, similar to IL-3 and IL-5, is a cytokine with a core of four bundled alpha ‑helices. Mature mouse GM-CSF shares 49-54% amino acid sequence identity with canine, feline, human, and porcine GM-CSF and 69% with rat GM-CSF. GM‑CSF exerts its biological effects through a heterodimeric receptor complex composed of GM-CSF R alpha /CD116 and the signal transducing common beta chain (CD131) which is also a component of the high-affinity receptors for IL-3 and IL-5. In addition, GM-CSF binds a naturally occurring soluble form of GM-CSF R alpha. The activity of GM-CSF is species specific between human and mouse. Mouse GM-CSF is only weakly active on rat cells, although rat GM-CSF is fully active on mouse cells. |
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Citations
- GM-CSF-licensed CD11b+ lung dendritic cells orchestrate Th2 immunity to Blomia tropicalis.
Authors: Zhou Q, Ho A, Schlitzer A, Tang Y, Wong K, Wong F, Chua Y, Angeli V, Mortellaro A, Ginhoux F, Kemeny D
J Immunol, 2014;193(2):496-509.
Species: Mouse
Sample Type: In Vivo
Application: Neut - A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.
Authors: Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J
Blood, 2007;109(5):2234-42.
Species: Mouse
Sample Type: Cell Culture Supernates
Application: WB - Recombinant Leishmania major secreting biologically active granulocyte-macrophage colony-stimulating factor survives poorly in macrophages in vitro and delays disease development in mice.
Authors: Dumas C, Muyombwe A, Roy G, Matte C, Ouellette M, Olivier M, Papadopoulou B
Infect. Immun., 2003;71(11):6499-509.
Species: Mouse
Sample Type: Whole Cells
Application: Neut - A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells.
Authors: Shih CC, Hu MC, Hu J
Blood, 2000;95(6):1957-66.
Species: Mouse
Sample Type: Whole Cells
Application: Neut
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