抗Mouse TIM-1/KIM-1/HAVCR抗体(Anti-Mouse TIM-1/KIM-1/HAVCR antibody)
掲載日情報：2021/01/28 現在Webページ番号：28612
Mouse TIM-1/KIM-1/HAVCRに対する抗体(Anti-Mouse TIM-1/KIM-1/HAVCR )です。
※ 本製品は研究用です。研究用以外には使用できません。
追加しました。
- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年06月17日 13時35分現在]
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Anti-Mouse TIM-1/KIM-1/HAVCR MAb (Clone 222414) |
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Anti-Mouse TIM-1/KIM-1/HAVCR MAb (Clone 222414) |
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Anti-Mouse TIM-1/KIM-1/HAVCR MAb (Clone 222414) |
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[在庫・価格 ：2025年06月17日 13時35分現在]
Anti-Mouse TIM-1/KIM-1/HAVCR MAb (Clone 222414)
文献数： 3
- 商品コード：MAB1817-100
- メーカー：RSD
- 包装：100μg
- 価格：¥100,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 別名：CD365 クローン：222414 Genbank No： 26762 Protein Accession No： NP_001160104 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Rat | |||||
| 交差性 | Mouse | 適用 | ELISA,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | |||||||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Mouse TIM-1/KIM-1/HAVCR MAb (Clone 222414)
文献数： 3
- 商品コード：MAB1817-500
- メーカー：RSD
- 包装：500μg
- 価格：¥232,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Mouse TIM-1/KIM-1/HAVCR サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAF1817，スタンダードとして#1817-TM-050を用いる。 別名：CD365 クローン：222414 Genbank No： 26762 Protein Accession No： NP_001160104 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Rat | |||||
| 交差性 | Mouse | 適用 | ELISA,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | |||||||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Mouse TIM-1/KIM-1/HAVCR MAb (Clone 222414)
文献数： 3
- 商品コード：MAB1817-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：CD365 クローン：222414 Genbank No： 26762 Protein Accession No： NP_001160104 |
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|---|---|---|---|---|---|---|---|
| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Rat | |||||
| 交差性 | Mouse | 適用 | ELISA,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
|
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| 製品記事 | 使いっきり抗体 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Mouse |
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| Label | Unconjugated |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse TIM‑1/KIM-1/HAVCRTyr22-Thr212Accession # NP_001160104 |
| Source | Monoclonal Rat IgG2B Clone # 222414 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects mouse TIM‑1/KIM-1/HAVCR in ELISAs and Western blots. This antibody does not cross-react with recombinant human (rh) TIM‑1, rmTIM-2, or rmTIM-3. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 1 µg/mL | Recombinant Mouse TIM‑1/KIM‑1/HAVCR (Catalog # 1817-TM) |
| Mouse TIM-1/KIM-1/HAVCR Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Mouse TIM‑1/KIM‑1/HAVCR Antibody (Catalog #MAB1817 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse TIM‑1/KIM‑1/HAVCR Biotinylated Antibody (Catalog #BAF1817 ) |
| ELISA Standard | Recombinant Mouse TIM-1/KIM-1/HAVCR Protein (Catalog #1817-TM ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: TIM-1/KIM-1/HAVCR | TIM-1 (T cell-immunoglobulin-mucin; also known as KIM-1 or HAVCR) is a 70-80 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules (1-4). This gene family is involved in the regulation of Th1 and Th2-cell-mediated immunity. In mouse, there are eight known TIM genes (# 1-8) vs. only three genes in human (# 1, 3, and 4) (1, 2). Mouse TIM-1 and -2 are counterparts of human TIM-1 while mouse TIM-5 through 8 have no human counterparts (2). Mouse TIM-1 is synthesized as a 305 amino acid (aa) precursor that contains a 21 aa signal sequence, a 216 aa extracellular domain (ECD), a 21 aa transmembrane segment and a 47 aa cytoplasmic domain (5, 6). The ECD contains one V-type Ig-like domain and a mucin region characterized by multiple T-S-P motifs. The mucin region undergoes extensive O-linked glycosylation. The mouse TIM-1 gene is highly polymorphic and, based on rat, may undergo alternate splicing (4, 6). For instance, HBA mice show a 15 aa deletion in the mucin region that occurs in BALB/c mice (6). This difference is associated with a decreased susceptibility to asthma. Other polymorphisms are also documented (6). In human, TIM-1 is known to circulate as a soluble form. It undergoes constitutive cleavage by an undefined MMP, releasing a 75-85 kDa soluble molecule (5). The same thing might be expected in mouse. The ECD of mouse TIM-1 is 50%, 39% and 80% aa identical to human, canine and rat TIM-1 ECD, respectively. The only two reported ligands for TIM-1 are TIM-4 and the hepatitis A virus (8, 9). However, others are believed to exist, and based on the ligand for TIM-3, one possibility might be an S-type lectin (10). TIM-1 ligation induces T cell proliferation and promotes cytokine production (1, 10). In particular, it induces IL-4 production, and requires the cytoplasmic tyrosine phosphorylation motif (5). |
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References
| Meyers, J.H. et al. (2005) Trends Mol. Med. 11:1471. | |
| Kuchroo, V.K. et al. (2003) Nat. Rev. Immunol. 3:454. | |
| Mariat, C. et al. (2005) Phil. Trans. R. Soc. B 360:1681. | |
| Ichimura, T. et al. (1998) J. Biol. Chem. 273:4135. | |
| de Souza, A.J. et al. (2005) Proc. Natl. Acad. Sci. USA 102:17113. | |
| McIntire, J.J. et al. (2001) Nat. Immunol. 2:1109. | |
| Bailly, V. et al. (2002) J. Biol. Chem. 277:39739. | |
| Feigelstock, D. et al. (1998) J. Virol. 72:6621. | |
| Zhu, C. et al. (2005) Nat. Immunol. 6:1245. | |
| Meyers, J.H. et al. (2005) Nat. Immunol. 6:455. | |
| Long Name: | T Cell Immunoglobulin Mucin-1 |
| Entrez Gene IDs: | 26762 (Human); 171283 (Mouse); 286934 (Rat); 102141332 (Cynomolgus Monkey) |
| Alternate Names: | CD365; HAVCR1; HAVCR-1; HAVCRT cell immunoglobin domain and mucin domain protein 1; hepatitis A virus cellular receptor 1; Kidney injury molecule 1; KIM1; KIM-1; T-cell immunoglobulin and mucin domain-containing protein 1; TIM1; TIM-1; TIM-1TIM; TIM1TIMD-1; TIMD1T-cell membrane protein 1 |
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Related Research Areas
| B Cell Markers | ||
| Co-stimulatory and Co-inhibitory Molecules | ||
| Infectious Diseases | ||
| Renal Markers | ||
| Special Glycoproteins | ||
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追加しました。
Related Product & Information
| Background | TIM-1/KIM-1/HAVCR |
|---|---|
| background_content | Background: TIM-1/KIM-1/HAVCR TIM-1 (T cell-immunoglobulin-mucin; also known as KIM-1 or HAVCR) is a 70-80 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules (1-4). This gene family is involved in the regulation of Th1 and Th2-cell-mediated immunity. In mouse, there are eight known TIM genes (# 1-8) vs. only three genes in human (# 1, 3, and 4) (1, 2). Mouse TIM-1 and -2 are counterparts of human TIM-1 while mouse TIM-5 through 8 have no human counterparts (2). Mouse TIM-1 is synthesized as a 305 amino acid (aa) precursor that contains a 21 aa signal sequence, a 216 aa extracellular domain (ECD), a 21 aa transmembrane segment and a 47 aa cytoplasmic domain (5, 6). The ECD contains one V-type Ig-like domain and a mucin region characterized by multiple T-S-P motifs. The mucin region undergoes extensive O-linked glycosylation. The mouse TIM-1 gene is highly polymorphic and, based on rat, may undergo alternate splicing (4, 6). For instance, HBA mice show a 15 aa deletion in the mucin region that occurs in BALB/c mice (6). This difference is associated with a decreased susceptibility to asthma. Other polymorphisms are also documented (6). In human, TIM-1 is known to circulate as a soluble form. It undergoes constitutive cleavage by an undefined MMP, releasing a 75-85 kDa soluble molecule (5). The same thing might be expected in mouse. The ECD of mouse TIM-1 is 50%, 39% and 80% aa identical to human, canine and rat TIM-1 ECD, respectively. The only two reported ligands for TIM-1 are TIM-4 and the hepatitis A virus (8, 9). However, others are believed to exist, and based on the ligand for TIM-3, one possibility might be an S-type lectin (10). TIM-1 ligation induces T cell proliferation and promotes cytokine production (1, 10). In particular, it induces IL-4 production, and requires the cytoplasmic tyrosine phosphorylation motif (5). |
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Citations
- The pathological role of IL-18Ralpha in renal ischemia/reperfusion injury.
Authors: Yano T, Nozaki Y, Kinoshita K, Hino S, Hirooka Y, Niki K, Shimazu H, Kishimoto K, Funauch M, Matsumura I
Lab Invest, 2015;95(1):78-91.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Frozen - KIM-1-mediated phagocytosis reduces acute injury to the kidney.
Authors: Yang L, Brooks C, Xiao S, Sabbisetti V, Yeung M, Hsiao L, Ichimura T, Kuchroo V, Bonventre J
J Clin Invest, 2015;125(4):1620-36.
Species: Mouse
Sample Type: Cell Lysates
Application: ELISA Capture - Proximal tubule-derived colony stimulating factor-1 mediates polarization of renal macrophages and dendritic cells, and recovery in acute kidney injury.
Authors: Wang Y, Chang J, Yao B, Niu A, Kelly E, Breeggemann M, Abboud Werner S, Harris R, Zhang M
Kidney Int, 2015;88(6):1274-1282.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded - HAVCR/KIM-1 activates the IL-6/STAT-3 pathway in clear cell renal cell carcinoma and determines tumor progression and patient outcome.
Authors: Cuadros T, Trilla E, Sarro E, Vila M, Vilardell J, de Torres I, Salcedo M, Lopez-Hellin J, Sanchez A, Ramon y Cajal S, Itarte E, Morote J, Meseguer A
Cancer Res, 2014;74(5):1416-28.
Species: Human
Sample Type: Whole Cells
Application: ICC - Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis.
Authors: Nozaki Y, Nikolic-Paterson DJ, Snelgrove SL
Kidney Int., 2012;81(9):844-55.
Species: Mouse
Sample Type: Tissue Homogenates
Application: WB - T cell Ig domain and mucin domain 1 engagement on invariant NKT cells in the presence of TCR stimulation enhances IL-4 production but inhibits IFN-gamma production.
Authors: Kim HS, Kim HS, Lee CW, Chung DH
J. Immunol., 2010;184(8):4095-106.
Species: Mouse
Sample Type: Whole Cells
Application: Flow - TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.
Authors: Nakae S, Iikura M, Suto H, Akiba H, Umetsu DT, DeKruyff RH, Saito H, Galli SJ
Blood, 2007;110(7):2565-8.
Species: Mouse
Sample Type: Cell Lysates
Application: WB
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