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抗RANK/TNFRSF11A抗体(Anti-RANK/TNFRSF11A, Human, Mouse-Mono antibody)

掲載日情報：2021/01/28 現在Webページ番号：28534

アールアンドディー システムズ /
R&D Systems, Inc.
[メーカー略称：RSD]

RANK/TNFRSF11Aに対する抗体(Anti-RANK/TNFRSF11A, Human, Mouse-Mono )です。
※ 本製品は研究用です。研究用以外には使用できません。

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価格

[在庫・価格 ：2026年04月06日 18時35分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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 納期 文献数
Anti-RANK/TNFRSF11A, Human, Mouse-Mono(80704)
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中止 		本製品は取扱中止になりました 8
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説明文
クローン：80704
Genbank No： 8792
Protein Accession No： Q9Y6Q6
法規制等
保存条件 法規備考
抗原種 Human 免疫動物 Mouse クラス IgG 標識 Unlabeled
交差性 Human 適用 ELISA,FCM,Western Blot
クロナリティ Monoclonal フォーマット 性状 Protein A/G Affinity Purified 吸収処理
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製品記事
関連記事 R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド
Anti-Human RANK/TNFRSF11A MAb (Clone 80704)
  • メーカーサイト
  • お問い合わせ
中止 		本製品は取扱中止になりました 0
  • メーカーサイト
  • お問い合わせ
説明文
クローン：80704
Genbank No： 8792
Protein Accession No： Q9Y6Q6
法規制等
保存条件 法規備考
抗原種 免疫動物 Mouse クラス IgG 標識 Unlabeled
交差性 Human 適用 ELISA,FCM,Western Blot
クロナリティ Monoclonal フォーマット 性状 Protein A/G Affinity Purified 吸収処理
掲載カタログ

製品記事 使いっきり抗体
関連記事 R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド

[在庫・価格 ：2026年04月06日 18時35分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

Anti-RANK/TNFRSF11A, Human, Mouse-Mono(80704)

文献数： 8

  • 商品コード：MAB683
  • メーカー：RSD
  • 包装：500μg
  • 本製品は取扱中止になりました

説明文 クローン：80704
Genbank No： 8792
Protein Accession No： Q9Y6Q6
法規制等
保存条件 法規備考
抗原種 Human 免疫動物 Mouse
交差性 Human 適用 ELISA,FCM,Western Blot
標識 Unlabeled 性状 Protein A/G Affinity Purified
吸収処理 クラス IgG
クロナリティ Monoclonal フォーマット
掲載カタログ

製品記事
関連記事 R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド
  • 使用文献
  • メーカーサイト
  • お問い合わせ
中止

Anti-Human RANK/TNFRSF11A MAb (Clone 80704)

文献数： 0

  • 商品コード：MAB683-SP
  • メーカー：RSD
  • 包装：25μg
  • 本製品は取扱中止になりました

説明文 クローン：80704
Genbank No： 8792
Protein Accession No： Q9Y6Q6
法規制等
保存条件 法規備考
抗原種 免疫動物 Mouse
交差性 Human 適用 ELISA,FCM,Western Blot
標識 Unlabeled 性状 Protein A/G Affinity Purified
吸収処理 クラス IgG
クロナリティ Monoclonal フォーマット
掲載カタログ

製品記事 使いっきり抗体
関連記事 R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド
  • メーカーサイト
  • お問い合わせ
中止



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Product Details

Species ReactivityHuman
LabelUnconjugated
ImmunogenMouse myeloma cell line NS0-derived recombinant human RANK/TNFRSF11A. extracellular domain
SourceMonoclonal Mouse IgG1 Clone # 80704
PurificationProtein A or G purified from hybridoma culture supernatant
SpecificityDetects human RANK/TNFRSF11A in ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) 4-1BB, rhBAFF R, rhCD27, rhCD30, rhCD40, rhDR3, rhDR6, rhEDAR, rhFas, rhGITR, rhHVEM, rhLymphotoxin beta R, rhNGF R, rhOPG, rhTAJ, rhTNF RI, rhTNF RII, or recombinant mouse (rm) OX40, and rmRANK is observed.


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Applications and Data

 Recommended
Concentration		Sample
Western Blot1 µg/mLRecombinant Human RANK/TNFRSF11A Fc Chimera (Catalog # 683-RK)
Flow Cytometry0.25 µg/106 cellsSee below
CyTOF-readyReady to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
Human RANK/TNFRSF11A Sandwich ImmunoassayReagent
ELISA Capture (Matched Antibody Pair)2-8 µg/mL Human RANK/TNFRSF11A Antibody (Catalog #MAB683 )
ELISA Detection (Matched Antibody Pair)0.1-0.4 µg/mL Human RANK/TNFRSF11A Biotinylated Antibody (Catalog #BAF683 )
ELISA Standard  Recombinant Human RANK/TNFRSF11A Fc Chimera Protein, CF (Catalog #683-RK )
Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website.

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Data Examples

Flow Cytometry Flow Cytometry RANK/TNFRSF11A Antibody (80704) [Unconjugated]
click image to view larger		Detection of RANK/TNFRSF11A in A431 Human Cell Line by Flow Cytometry.A431 human epithelial carcinoma cell line was stained with Mouse Anti-Human RANK/TNFRSF11A Monoclonal Antibody (Catalog # MAB683, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).
ReconstitutionReconstitute at 0.5 mg/mL in sterile PBS.Reconstitution Buffer Available
ShippingThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: RANK/TNFRSF11A

RANK (receptor activator of NF-kappa B, also known as TRANCE receptor, osteoclast differentiation factor receptor [ODFR]) and TNFRSF11A is a member of the tumor necrosis factor receptor family. The full length human RANK cDNA encodes a type I transmembrane protein of 616 amino acids with a predicted 184 amino acid extracellular domain and a 383 amino acid cytoplasmic domain. The extracellular domain contains two potential N-linked glycosylation sites. RANK shares significant amino acid homology with other members of the TNF R family in its extracellular four cysteine-rich repeats. Human and murine RANK share 81% amino acid identity in their extracellular domains. RANK is widely expressed with highest levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. RANK is expressed in dendritic cells. In activated human peripheral blood T lymphocytes, RANK expression is induced by IL-4 and TGF-beta. Multiple tumor necrosis factor receptor-associated factors (TRAFs) are involved in the signaling of RANK. TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand [RANKL], osteoprotegerin ligand [OPGL], and osteoclast differentiation factor [ODF]) is the ligand for RANK. The biological functions mediated through RANK include activation of NF-kappa B and c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis, and lymph node organogenesis. Soluble RANK is able to block TRANCE induced biological activity.

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References

Anderson, D.M. et al. (1997) Nature 390:175.
Nakagawa, N. et al. (1998) Biochem. Biophys. Res. Commun. 245:382.
Long Name:Receptor Activator of NF-kappa-B
Entrez Gene IDs:8792 (Human); 21934 (Mouse)
Alternate Names:CD265 antigen; CD265; FEO; loss of heterozygosity, 18, chromosomal region 1; ODFR; ODFROSTS; OFE; OPTB7; Osteoclast differentiation factor receptor; PDB2; RANK; RANKLOH18CR1; Receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; TNFRSF11A; TRANCE R; TRANCER; tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily, member 11a, activator of NFKB; tumor necrosis factor receptor superfamily, member 11a, NFKB activator

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Related Research Areas

Cytokine and Growth Factor Receptors on VSMC
Mouse Tissue-Resident Macrophage Markers
Osteoblast and Osteoclast Markers
Regulatory T Cells (Tregs)
TNF Superfamily
TNF Superfamily Receptors
  1. Langerhans cell precursors acquire RANK/CD265 in prenatal human skin.
    Authors: Schoppl A, Botta A, Prior M, Akgun J, Schuster C, Elbe-Burger A
    Acta Histochem, 2015;117(4):425-30.
    Species: Human
    Sample Type: Whole Tissue
    Application: IHC Frozen


Flow Cytometry
Detection of RANK/TNFRSF11A in A431 Human Cell Line by Flow Cytometry.
A431 human epithelial carcinoma cell line was stained with Mouse Anti-Human RANK/TNFRSF11A Monoclonal Antibody (Catalog # MAB683, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).


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Related Product & Information

BackgroundRANK/TNFRSF11A
background_contentBackground:
RANK/TNFRSF11A
RANK (receptor activator of NF-kappa B, also known as TRANCE receptor, osteoclast differentiation factor receptor [ODFR]) and TNFRSF11A is a member of the tumor necrosis factor receptor family. The full length human RANK cDNA encodes a type I transmembrane protein of 616 amino acids with a predicted 184 amino acid extracellular domain and a 383 amino acid cytoplasmic domain. The extracellular domain contains two potential N-linked glycosylation sites. RANK shares significant amino acid homology with other members of the TNF R family in its extracellular four cysteine-rich repeats. Human and murine RANK share 81% amino acid identity in their extracellular domains. RANK is widely expressed with highest levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. RANK is expressed in dendritic cells. In activated human peripheral blood T lymphocytes, RANK expression is induced by IL-4 and TGF-beta. Multiple tumor necrosis factor receptor-associated factors (TRAFs) are involved in the signaling of RANK. TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand [RANKL], osteoprotegerin ligand [OPGL], and osteoclast differentiation factor [ODF]) is the ligand for RANK. The biological functions mediated through RANK include activation of NF-kappa B and c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis, and lymph node organogenesis. Soluble RANK is able to block TRANCE induced biological activity.


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Citations

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
  1. Langerhans cell precursors acquire RANK/CD265 in prenatal human skin.
    Authors: Schoppl A, Botta A, Prior M, Akgun J, Schuster C, Elbe-Burger A
    Acta Histochem, 2015;117(4):425-30.
    Species: Human
    Sample Type: Whole Tissue
    Application: IHC Frozen

  2. Receptor activator for NF-kappaB ligand in acute myeloid leukemia: expression, function, and modulation of NK cell immunosurveillance.
    Authors: Schmiedel B, Nuebling T, Steinbacher J, Malinovska A, Wende C, Azuma M, Schneider P, Grosse-Hovest L, Salih H
    J Immunol, 2013;190(2):821-31.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow

  3. RANKL expression, function, and therapeutic targeting in multiple myeloma and chronic lymphocytic leukemia.
    Authors: Schmiedel B, Scheible C, Nuebling T, Kopp H, Wirths S, Azuma M, Schneider P, Jung G, Grosse-Hovest L, Salih H
    Cancer Res, 2013;73(2):683-94.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow

  4. Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer.
    Authors: Zhao E, Wang L, Dai J, Kryczek I, Wei S, Vatan L, Altuwaijri S, Sparwasser T, Wang G, Keller E, Zou W
    Oncoimmunology, 2012;1(2):152-161.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow

  5. Epidermal receptor activator of NF-kappaB ligand controls Langerhans cells numbers and proliferation.
    Authors: Barbaroux JB, Beleut M, Brisken C, Mueller CG, Groves RW
    J. Immunol., 2008;181(2):1103-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow

  6. High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4+ T lymphocytes.
    Authors: Vernal R, Dutzan N, Hernandez M, Chandia S, Puente J, Leon R, Garcia L, Del Valle I, Silva A, Gamonal J
    J. Periodontol., 2006;77(10):1772-80.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow



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