抗Human Latent TGF-beta bp1抗体(Anti-Human Latent TGF-beta bp1 antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Unconjugated
Immunogen	Human platelet-derived large latent TGF-beta 1 complex
Source	Monoclonal Mouse IgG1 Clone # 35409
Purification	Protein A or G purified from ascites
Specificity	Detects human LTBP-1 from the large latent TGF-beta 1 complex.

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Applications and Data

	Recommended Concentration	Sample
Western Blot	1 µg/mL	Large latent TGF-beta complex from human platelets under non-reducing conditions only
Immunoaffinity Purification	This antibody can be used to affinity purify the large latent TGF-beta complex (containing both the 230 and 195 kDa binding protein) and will also pull out “free” binding protein that is not associated with the small latent TGF-beta.

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Related Product & Information

Entrez Gene IDs	4052 (Human)
Background	Latent TGF-beta bp1
background_content	Background: Latent TGF-beta bp1 TGF-beta  is synthesized as high molecular weight latent complexes. In platelets, the large latent TGF-beta 1 complex is composed of three components: mature TGF-beta 1 dimer; latency associated peptide; and a latent TGF-beta binding protein (LTBP) (1-3).The cDNAs for four binding proteins (LTBP-1, -2, -3 and -4) have now been cloned (4-5).

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Citations

1. Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells
   Authors: AJ Alshawaf, S Viventi, W Qiu, G D'Abaco, B Nayagam, M Erlichster, G Chana, I Everall, J Ivanusic, E Skafidas, M Dottori
   Sci Rep, 2018;8(1):603.
   Species: Human
   Sample Type: Whole Cells
   Application: ICC


2. ATRA modulates mechanical activation of TGF-? by pancreatic stellate cells
   Sci Rep, 2016;6(0):27639.
   Species: Human
   Sample Type: Whole Cells
   Application: IHC - PFA fixed


3. Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor beta1 (TGF-beta1) activation.
   Authors: Brophy T, Coller B, Ahamed J
   J Biol Chem, 2013;288(15):10628-39.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


4. Kidney transplantation: analysis of the expression and T cell-mediated activation of latent TGF-beta.
   Authors: Willet J, Pichitsiri W, Jenkinson S, Brain J, Wood K, Alhasan A, Spielhofer J, Robertson H, Ali S, Kirby J
   J Leukoc Biol, 2013;93(4):471-8.
   Species: Human
   Sample Type: Whole Cells
   Application: ICC


5. Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31.
   Authors: Shen M, Siu S, Byrd S, Edelmann KH, Patel N, Ketchem RR, Mehlin C, Arnett HA, Hasegawa H
   Exp. Cell Res., 2011;317(7):976-93.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


6. Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta.
   Authors: Massam-Wu T, Chiu M, Choudhury R
   J. Cell. Sci., 2010;123(0):3006-18.
   Species: Human
   Sample Type: Cell Lysates
   Application: IP


7. Matrix association of latent TGF-beta binding protein-2 (LTBP-2) is dependent on fibrillin-1.
   Authors: Vehvilainen P, Hyytiainen M, Keski-Oja J
   J. Cell. Physiol., 2009;221(3):586-93.
   Species: Human
   Sample Type: Cell Culture Supernates
   Application: WB


8. Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway.
   Authors: Gomez D, Al Haj Zen A, Borges LF, Philippe M, Gutierrez PS, Jondeau G, Michel JB, Vranckx R
   J. Pathol., 2009;218(1):131-42.
   Species: Human
   Sample Type: Whole Tissue
   Application: IHC Frozen


9. Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates.
   Authors: Torrealba JR, Katayama M, Fechner JH, Jankowska-Gan E, Kusaka S, Schultz JM, Hu H, Hamawy MM, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham WJ, Knechtle SJ
   J. Immunol., 2004;172(9):5753-64.
   Species: Primate - Macaca mulatta (Rhesus Macaque)
   Sample Type: Tissue Homogenates
   Application: WB

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