抗Human HVEM/TNFRSF14抗体(Anti-Human HVEM/TNFRSF14 antibody)
掲載日情報：2021/01/28 現在Webページ番号：28308
Human HVEM/TNFRSF14に対する抗体(Anti-Human HVEM/TNFRSF14 )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2025年08月02日 20時35分現在]
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Anti-Human HVEM/TNFRSF14 MAb (Clone 94801) |
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Anti-Human HVEM/TNFRSF14 MAb (Clone 94801) |
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Anti-Human HVEM/TNFRSF14 MAb (Clone 94801) |
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[在庫・価格 ：2025年08月02日 20時35分現在]
Anti-Human HVEM/TNFRSF14 MAb (Clone 94801)
文献数： 0
- 商品コード：MAB356-100
- メーカー：RSD
- 包装：100μg
- 価格：¥78,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 別名：ATAR クローン：94801 Genbank No： 8764 Protein Accession No： AAB58354 |
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| 別包装品 | 別包装品あり | ||||||
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| 保存条件 | 法規備考 | ||||||
| 抗原種 | 免疫動物 | Mouse | |||||
| 交差性 | Human | 適用 | ELISA,FCM,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
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| 製品記事 | |||||||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Human HVEM/TNFRSF14 MAb (Clone 94801)
文献数： 0
- 商品コード：MAB356-500
- メーカー：RSD
- 包装：500μg
- 価格：¥259,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human HVEM/TNFRSF14 サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAF356，スタンダードとして#356-HV-100を用いる。 別名：ATAR クローン：94801 Genbank No： 8764 Protein Accession No： AAB58354 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | 法規備考 | ||||||
| 抗原種 | 免疫動物 | Mouse | |||||
| 交差性 | Human | 適用 | ELISA,FCM,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | |||||||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Human HVEM/TNFRSF14 MAb (Clone 94801)
文献数： 0
- 商品コード：MAB356-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥27,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：ATAR クローン：94801 Genbank No： 8764 Protein Accession No： AAB58354 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | 法規備考 | ||||||
| 抗原種 | 免疫動物 | Mouse | |||||
| 交差性 | Human | 適用 | ELISA,FCM,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | 使いっきり抗体 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human |
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| Label | Unconjugated |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human HVEM/TNFRSF14Pro37-Val202 (Ser108Thr and Ala140Arg)Accession # AAB58354 |
| Source | Monoclonal Mouse IgG1 Clone # 94801 |
| Purification | Protein A or G purified from ascites |
| Specificity | Detects human HVEM/TNFRSF14 in direct ELISAs and Western blots. In direct ELISAs, approximately 5% cross-reactivity with recombinant human (rh) CD30 and no cross-reactivity with rh4-1BB, rhCD27, rhCD40, rhDR3, rhDR6, rhFas, rhGITR, rhNGF-R, rhOPG, rhRANK, recombinant mouse (rm) RANK, rhTAJ, rhTNF RI, rhTNF RII, or rmTNF RI is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 1 µg/mL | Recombinant Human HVEM/TNFRSF14 Fc Chimera (Catalog # 356-HV) |
| Flow Cytometry | 0.25 µg/106 cells | See below |
| CyTOF-ready | Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation. | |
| Human HVEM/TNFRSF14 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human HVEM/TNFRSF14 Antibody (Catalog #MAB356 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Human HVEM/TNFRSF14 Biotinylated Antibody (Catalog #BAF356 ) |
| ELISA Standard | Recombinant Human HVEM/TNFRSF14 Fc Chimera Protein (Catalog #356-HV ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | ||
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Data Example
| Flow Cytometry |
![Flow Cytometry HVEM/TNFRSF14 Antibody (94801) [Unconjugated]](http://resources.rndsystems.com/images/datasheets/antibody/HVEM_MAB356_Flow_Cytometry_19907.jpg) click image to view larger | Detection of HVEM/TNFRSF14 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human HVEM/TNFRSF14 Monoclonal Antibody (Catalog # MAB356, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B). View our protocol for Staining Membrane-associated Proteins. | |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available | |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | ||
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution.6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: HVEM/TNFRSF14 | Herpesvirus entry mediator (HVEM), also referred to as TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. In the TNF superfamily nomenclature, HVEM is referred to as TNFRSF14. Human HVEM cDNA encodes a 283 amino acid (aa) protein with a probable 36 aa signal peptide, a 166 aa extracellular domain, a 23 aa transmembrane region and a 58 aa cytoplasmic region. The extracellular domain of HVEM contains several cysteine-rich repeats characteristic of TNF receptor superfamily members. The short cytoplasmic region lacks a death domain present in some TNF receptor family members, but contains a TRAF (TNF receptor-associated factor) interaction domain. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D. Two TNF superfamily ligands, including the secreted TNF‑ beta (lymphotoxin alpha ) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LT beta R, the receptor for lymphotoxin alpha beta heterotrimer. |
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| References: |
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| Long Name: | Herpesvirus Entry Mediator | ||
| Entrez Gene IDs: | 8764 (Human); 230979 (Mouse); 102137807 (Cynomolgus Monkey) | ||
| Alternate Names: | ATAR; CD270 antigen; CD270; CD40-like protein; Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; HVEM; HVEMTR2HVEAATAR; LIGHTR; TNFRSF14; tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entrymediator); Tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2 | ||
| Related Research Areas | B Cell Development and DifferentiationCo-stimulatory and Co-inhibitory MoleculesMonocyte MarkersRegulation of Apoptosis by TNF Superfamily MembersRegulation of Natural Killer Cell Co-stimulation by TNF Superfamily MembersRegulation of T Cell Co-stimulation by TNF Superfamily Members | ||
| TNF Superfamily | |||
| TNF Superfamily Receptors | |||
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| Flow Cytometry | |
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 | Detection of HVEM/TNFRSF14 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human HVEM/TNFRSF14 Monoclonal Antibody (Catalog # MAB356, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B). View our protocol for Staining Membrane-associated Proteins. |
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Related Product & Information
| Background | HVEM/TNFRSF14 |
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| background_content | Background: HVEM/TNFRSF14 Herpesvirus entry mediator (HVEM), also referred to as TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. In the TNF superfamily nomenclature, HVEM is referred to as TNFRSF14. Human HVEM cDNA encodes a 283 amino acid (aa) protein with a probable 36 aa signal peptide, a 166 aa extracellular domain, a 23 aa transmembrane region and a 58 aa cytoplasmic region. The extracellular domain of HVEM contains several cysteine-rich repeats characteristic of TNF receptor superfamily members. The short cytoplasmic region lacks a death domain present in some TNF receptor family members, but contains a TRAF (TNF receptor-associated factor) interaction domain. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D. Two TNF superfamily ligands, including the secreted TNF‑ beta (lymphotoxin alpha ) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LT beta R, the receptor for lymphotoxin alpha beta heterotrimer. |
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Citations
- Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen.
Authors: de Mare-Bredemeijer E, Shi X, Mancham S, van Gent R, van der Heide-Mulder M, de Boer R, Heemskerk M, de Jonge J, van der Laan L, Metselaar H, Kwekkeboom J
J Immunol, 2015;195(4):1838-48.
Species: Human
Sample Type: Whole Cells
Application: Neut - CD160 isoforms and regulation of CD4 and CD8 T-cell responses.
Authors: El-Far, Mohamed, Pellerin, Charles, Pilote, Louise, Fortin, Jean-Fra, Lessard, Ivan A D, Peretz, Yoav, Wardrop, Elizabet, Salois, Patrick, Bethell, Richard, Cordingley, Michael, Kukolj, George
J Transl Med, 2014;12(0):217.
Species: Human
Sample Type: Whole Cells
Application: Neut - T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment.
Authors: Cheung TC, Oborne LM, Steinberg MW
J. Immunol., 2009;183(11):7286-96.
Species: Human
Sample Type: Whole Cells
Application: Flow - LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes.
Authors: Kang YM, Kim SY, Kang JH
Arthritis Rheum., 2007;56(4):1106-17.
Species: Human
Sample Type: Whole Cells
Application: Flow
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