抗Human VEGF R1抗体(Anti-Human VEGF R1 antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Unconjugated
Immunogen	S. frugiperda insect ovarian cell line Sf 21-derived recombinant human VEGF R1/Flt-1Ser27-His687Accession # NP_001153392
Source	Monoclonal Mouse IgG1 Clone # 49560
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human VEGF R1/Flt-1 in direct ELISAs and Western blots. In Western blots, this antibody does not cross-react with recombinant mouse VEGF R1, recombinant human (rh) VEGF R2, rhVEGF R3, or rhVEGF R4.

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Applications and Data

	Recommended Concentration	Sample
Western Blot	1 µg/mL	Recombinant Human VEGF R1/Flt-1 Fc Chimera (Catalog # 321-FL) under non-reducing conditions only
Flow Cytometry	2.5 µg/106 cells	See below
CyTOF-ready	Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Flow Cytometry
	Detection of VEGF R1/Flt‑1 in HUVEC Human Cells by Flow Cytometry. HUVEC human umbilical vein endothelial cells was stained with Mouse Anti-Human VEGF R1/Flt‑1 Monoclonal Antibody (Catalog # MAB321, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).

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Related Product & Information

Long Name	Vascular Endothelial Growth Factor Receptor 1
Background	VEGF R1/Flt-1
background_content	Background: VEGF R1/Flt-1 Vascular Endothelial Growth Factor Receptor 1 (VEGF R1) is a receptor tyrosine kinase that is expressed primarily on endothelial cells and plays a role in vasculogenesis and angiogenesis. A soluble variant of VEGF R1 was also reported to bind VEGF and PlGF with high affinity and function as a potent VEGF antagonist.

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Citations

1. Synergic effects of VEGF-A and SDF-1 on the angiogenic properties of endothelial progenitor cells
   Authors: Gabriela Odent Grig
   J Tissue Eng Regen Med, 2016;0(0):.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms.
   Authors: Jarajapu Y, Hazra S, Segal M, Li Calzi S, Jadhao C, Qian K, Mitter S, Raizada M, Boulton M, Grant M
   PLoS ONE, 2014;9(4):e93965.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


3. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.
   Authors: Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang LP, Gimotty PA, Gilks CB, Lal P, Zhang L, Coukos G
   Nature, 2011;475(7355):226-30.
   Species: Human
   Sample Type: Whole Cells
   Application: Neut


4. Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model.
   Authors: Brave SR, Eberlein C, Shibuya M, Wedge SR, Barry ST
   Angiogenesis, 2010;13(4):337-47.
   Species: Human
   Sample Type: Cell Lysates
   Application: ELISA Development


5. Down-regulation of vascular endothelial growth factor receptor 2 is a major molecular determinant of proteasome inhibitor-mediated antiangiogenic action in endothelial cells.
   Authors: Meissner M, Reichenbach G, Stein M, Hrgovic I, Kaufmann R, Gille J
   Cancer Res., 2009;69(5):1976-84.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


6. Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels.
   Authors: Riccioni R, Senese M, Diverio D, Riti V, Mariani G, Boe A, LoCoco F, Foa R, Peschle C, Sporn M, Testa U
   Leuk. Res., 2008;32(8):1244-58.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


7. Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts.
   Authors: Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, Petrucci E, Cedrone M, Lo-Coco F, Foa R, Peschle C, Testa U
   Stem Cells, 2007;25(8):1862-71.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


8. Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells.
   Authors: Lin YL, Liang YC, Chiang BL
   J. Leukoc. Biol., 2007;82(6):1473-80.
   Species: Human
   Sample Type: Whole Cells
   Application: Neut


9. Dissecting the role of endothelial SURVIVIN DeltaEx3 in angiogenesis.
   Authors: Caldas H, Fangusaro JR, Boue DR, Holloway MP, Altura RA
   Blood, 2007;109(4):1479-89.
   Species: Human
   Sample Type: Whole Cells
   Application: Neut


10. Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1.
    Authors: Caine GJ, Blann AD, Stonelake PS, Ryan P, Lip GY
    Eur. J. Clin. Invest., 2003;33(10):883-90.
    Species: Human
    Sample Type: Plasma
    Application: ELISA Development

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