抗TNF-β抗体(Anti-TNF-β, Human, Mouse-Mono antibody)
掲載日情報：2018/11/26 現在Webページ番号：28187
TNF-βに対する抗体(Anti-TNF-β, Human, Mouse-Mono )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2026年04月06日 15時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-TNF-β, Human, Mouse-Mono(5802.21) |
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Anti-Human Lymphotoxin-alpha/TNF-beta MAb (Clone 5802) |
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[在庫・価格 ：2026年04月06日 15時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-TNF-β, Human, Mouse-Mono(5802.21)
文献数： 1
- 商品コード：MAB211
- メーカー：RSD
- 包装：500μg
- 価格：¥95,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 別名：LT クローン：5802 Genbank No： 4049 Protein Accession No： P01374 |
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| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | Human | 免疫動物 | Mouse | ||||
| 交差性 | Human | 適用 | IC,Neutralising | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | Helper T Cells Marker Antibodies |
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Anti-Human Lymphotoxin-alpha/TNF-beta MAb (Clone 5802)
文献数： 1
- 商品コード：MAB211-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥25,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：LT クローン：5802 Genbank No： 4049 Protein Accession No： P01374 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | 法規備考 | ||||||
| 抗原種 | 免疫動物 | Mouse | |||||
| 交差性 | Human | 適用 | IC,Neutralising | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | Helper T Cells Marker Antibodies 使いっきり抗体 |
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Product Details
| Species Reactivity | Human |
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| Label | Unconjugated |
| Immunogen | E. coli-derived recombinant human Lymphotoxin‑ alpha /TNF‑ beta Leu35-Leu205Accession # P01374 |
| Source | Monoclonal Mouse IgG1 Clone # 5802 |
| Purification | Protein A or G purified from ascites |
| Specificity | Detects human Lymphotoxin‑ alpha /TNF‑ beta in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) TNF-alpha is observed. Neutralizes the biological activity of recombinant human TNF-beta. Will not neutralize the biological activity of recombinant human TNF-alpha or recombinant mouse TNF-alpha. |
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Applications and Data
| Recommended Concentration | Sample | |
| Immunocytochemistry | 8-25 µg/mL | See below |
| Neutralization | Measured by its ability to neutralize Lymphotoxin‑ alpha /TNF‑ beta -induced cytotoxicity in the L‑929 mouse fibroblast cell line. Matthews, N. and M. L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M. J. et al. (eds): IRL Press. 221. The Neutralization Dose (ND50) is typically 0.1-0.2 µg/mL in the presence of 0.25 ng/mL Recombinant Human Lymphotoxin‑ alpha /TNF‑ beta and 1 µg/mL actinomycin D. | |
| Neutralization | |
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 | Cytotoxicity Induced by Lymphotoxin‑ alpha /TNF‑ beta and Neutralization by Human Lymphotoxin‑ alpha /TNF‑ beta Antibody. Recombinant Human Lymphotoxin‑ alpha /TNF‑ beta (Catalog # 211‑TB) induces cytotoxicity in the the L‑929 mouse fibroblast cell line in a dose-dependent manner (orange line), as measured by crystal violet staining. Cytotoxicity elicited by Recombinant Human Lymphotoxin‑ alpha /TNF‑ beta (0.25 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human Lymphotoxin‑ alpha /TNF‑ beta Monoclonal Antibody (Catalog # MAB211). The ND50 is typically 0.1‑0.2 µg/mL in the presence of the metabolic inhibitor actinomycin D (1 µg/mL). |
| Immunocytochemistry | |
 | Lymphotoxin‑ alpha /TNF‑ beta in Human PBMCs. Lymphotoxin‑ alpha /TNF‑ beta was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) stimulated with LPS and monensin using Mouse Anti-Human Lymphotoxin‑ alpha /TNF‑ beta Monoclonal Antibody (Catalog # MAB211) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Non-adherent Cells. |
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Related Product & Information
| Long Name | Tumor Necrosis Factor beta |
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| Entrez Gene IDs | 4049 (Human); 16992 (Mouse) |
| Background | Lymphotoxin-alpha/TNF-beta |
| background_content | Background: Lymphotoxin-alpha/TNF-beta Tumor necrosis factor beta (TNF-beta ), also known as lymphotoxin-alpha (LT-alpha ), and TNF-alpha, are two structurally and functionally related proteins that bind to the same cell surface receptors (TNF RI and TNF RII) and produce a vast range of similar, but not identical, effects. Among these effects is the ability to kill certain tumor cells directly, from which the names tumor necrosis factor and lymphotoxin both derive. Mature TNF-beta /LT-alpha and TNF-alpha share approximately 35% protein sequence homology and the biologically active secreted forms of both proteins are homotrimers. Whereas TNF-alpha can exist as a type II membrane protein, TNF-beta /LT-alpha possesses a typical signal peptide sequence and is a secreted protein. It has been shown that TNF-beta /LT-alpha is also present on the cell surface of activated T, B and LAK cells as a heteromeric complex with LT-beta, a type II membrane protein that is another member of the TNF ligand family. The genes for TNF-alpha, TNF-beta /LT-alpha, and LT-beta are closely linked within the major histocompatibility complex. TNF-beta /LT-alpha is expressed in activated T- and B-lymphocytes. In addition to its cytotoxic action on tumor cells, TNF-beta /LT-alpha has been shown to be a mediator of inflammation and immune function. Evidence is also accumulating that TNF-beta /LT-alpha and TNF-alpha are mediators in the pathogenesis of certain autoimmune diseases. TNF-beta /LT-alpha has also been shown to have a role in lymphoid organ development. Human and mouse TNF-beta /LT-alpha share approximately 74% homology in their amino acid sequence and exhibit cross-species activity. |
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
- True infliximab resistance in rheumatoid arthritis: a role for lymphotoxin alpha?
Authors: Buch MH, Conaghan PG, Quinn MA, Bingham SJ, Veale D, Emery P
Ann. Rheum. Dis., 2004;63(10):1344-6.
Species: Human
Sample Type: Whole Tissue
Application: IHC Frozen
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