抗IL-18 Receptor抗体(Anti-IL-18 Receptor, Mouse, Goat-Poly, Biotin antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Mouse
Label	Biotin
Immunogen	Mouse myeloma cell line NS0-derived recombinant mouse IL‑18 R alpha /IL‑1 R5Ser19-Gly326Accession # Q61098
Source	Polyclonal Goat IgG
Purification	Antigen Affinity-purified
Specificity	Detects mouse IL‑18 R alpha /IL‑1 R5 in Western blots. In Western blots, approximately 10% cross‑reactivity with recombinant human IL-18 R is observed.

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Applications and Data

	Recommended Concentration	Sample
Western Blot	0.1 µg/mL	Recombinant Mouse IL‑18 R alpha /IL‑1 R5

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Related Product & Information

Long Name	Interleukin 18 Receptor alpha
Background	IL-18 R alpha/IL-1 R5
background_content	Background: IL-18 R alpha/IL-1 R5 Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immuno-regulatory functions with IL-12. The functional IL-18 receptor complex is composed of two subunits designated IL18 R alpha (also termed IL-1 R5 and IL-1 Rrp) and IL-18 R beta (also termed IL-1 R7 and AcPL). Both IL-18 R alpha and IL-18 R beta belong to the IL-1 receptor superfamily. Although IL-18 R by itself binds IL-18 with low affinity and IL-18 R beta does not bind IL18 in vitro, coexpression of IL-18 R alpha and IL18 R beta is required for high affinity binding and IL-18 responsiveness. Human IL-18 R cDNA encodes a 541 amino acid (aa) precursor type I membrane protein with a hydrophobic signal, an extracellular domain comprised of three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic region of approximately 200 aa residues. Human and mouse IL-18 R share 65% amino acid sequence homology. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta.

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Citations

1. Increased cytokine production in IL-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling (SOCS).
   Authors: Nold-Petry CA, Nold MF, Nielsen JW, Bustamante A, Zepp JA, Storm KA, Hong JW, Kim SH, Dinarello CA
   J. Biol. Chem., 2009;0(0):.
   Species: Mouse
   Sample Type: Whole Cells
   Application: ICC


2. Protection of CD8+ T cells from activation-induced cell death by IL-18.
   Authors: Li W, Kashiwamura S, Ueda H, Sekiyama A, Okamura H
   J. Leukoc. Biol., 2007;82(1):142-51.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


3. DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections.
   Authors: French AR, Sjolin H, Kim S, Koka R, Yang L, Young DA, Cerboni C, Tomasello E, Ma A, Vivier E, Karre K, Yokoyama WM
   J. Immunol., 2006;177(8):4981-90.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


4. Distinct modulatory effects of LPS and CpG on IL-18-dependent IFN-gamma synthesis.
   Authors: Gould MP, Greene JA, Bhoj V, DeVecchio JL, Heinzel FP
   J. Immunol., 2004;172(3):1754-62.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow

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