抗DLL1抗体(Anti-DLL1, Goat-Poly, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：27931
DLL1に対する抗体(Anti-DLL1, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年04月25日 19時55分現在]
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[在庫・価格 ：2025年04月25日 19時55分現在]
Anti-DLL1, Goat-Poly, Biotin
文献数： 1
- 商品コード：BAF1818
- メーカー：RSD
- 包装：50μg
- 価格：¥111,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human DLL1 サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB1818-500，スタンダードとして#1818-DL-050を用いる。 別名：Delta Genbank No： 28514 Protein Accession No： AAG09716 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Human | 免疫動物 | Goat |
| 交差性 | Human | 適用 | ELISA |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | R&D Systems社 NotchリガンドDLL1の関連製品 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human |
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| Label | Biotin |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human DLL1Ser22-Gly540Accession # AAG09716 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects recombinant human DLL1 in ELISAs. In sandwich immunoassays, less than 15% cross-reactivity with recombinant mouse (rm) DLL1 and recombinant rat DLL1 is observed, and less than 0.05% cross-reactivity with recombinant human DLL4 and rmDLL4 is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Human DLL1 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human DLL1 Antibody (Catalog #MAB1818 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Human DLL1 Biotinylated Antibody (Catalog #BAF1818 ) |
| ELISA Standard | Recombinant Human DLL1 Protein, CF (Catalog #1818-DL ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: DLL1 | Delta-like protein 1 (DLL1) is a 90-100 kDa type I transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. Mature human DLL1 consists of a 528 amino acid (aa) extracellular domain (ECD) with one DSL domain and eight EGF-like repeats, a 23 aa transmembrane segment, and a 155 aa cytoplasmic domain (1). Within the ECD, human DLL1 shares 91% aa sequence identity with mouse and rat DLL1. It shares 26%, 37%, and 54% aa sequence identity with DLL2, 3, and 4, respectively. A 60 kDa ECD fragment released by ADAM9, 12, or 17 mediated proteolysis, promotes the proliferation of hematopoietic progenitor cells (2, 3). The residual membrane-bound portion of DLL1 can be cleaved by presenilin-dependent gamma -secretase, enabling the cytoplasmic domain to migrate to the nucleus (4). DLL1 localizes to adherens junctions on neuronal processes through its association with the scaffolding protein MAGI1 (5). DLL1 is widely expressed, and it plays an important role in embryonic somite formation, cochlear hair cell differentiation, plus B and T lymphocyte differentiation (6-11). The upregulation of DLL1 in arterial endothelial cells following injury or angiogenic stimulation is central to postnatal arteriogenesis (12). DLL1 is also overexpressed in cervical carcinoma and glioma and contributes to tumor progression (1, 13). |
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References
| Gray, G.E. et al. (1999) Am. J. Pathol. 154:785. | |
| Dyczynska, E. et al. (2007) J. Biol. Chem. 282:436. | |
| Karanu, F.N. et al. (2001) Blood 97:1960. | |
| Ikeuchi, T. and S.S. Sisodia (2003) J. Biol. Chem. 278:7751. | |
| Mizuhara, E. et al. (2005) J. Biol. Chem. 280:26499. | |
| Takahashi, Y. et al. (2003) Development 130:4259. | |
| Teppner, I. et al. (2007) BMC Dev. Biol. 7:68. | |
| Kiernan, A.E. et al. (2005) Development 132:4353. | |
| Schmitt, T.M. and J.C. Zuniga-Pflucker (2002) Immunity 17:749. | |
| Hozumi, K. et al. (2004) Nat. Immunol. 5:638. | |
| Santos, M.A. et al. (2007) Proc. Natl. Acad. Sci. USA 104:15454. | |
| Limbourg, A. et al. (2007) Circ. Res. 100:363. | |
| Purow, B.W. et al. (2005) Cancer Res. 65:2353. | |
| Long Name: | Delta-like 1 |
| Entrez Gene IDs: | 28514 (Human); 13388 (Mouse); 84010 (Rat) |
| Alternate Names: | delta (Drosophila)-like 1; Delta 1; Delta; Delta1; delta-like 1 (Drosophila); delta-like protein 1; DL1; DLL1; Drosophila Delta homolog 1; H-Delta-1 |
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Related Research Areas
| Notch Family | ||
| Notch Pathway | ||
| Somite Markers | ||
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Related Product & Information
| Background | DLL1 |
|---|---|
| background_content | Background: DLL1 Delta-like protein 1 (DLL1) is a 90-100 kDa type I transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. Mature human DLL1 consists of a 528 amino acid (aa) extracellular domain (ECD) with one DSL domain and eight EGF-like repeats, a 23 aa transmembrane segment, and a 155 aa cytoplasmic domain (1). Within the ECD, human DLL1 shares 91% aa sequence identity with mouse and rat DLL1. It shares 26%, 37%, and 54% aa sequence identity with DLL2, 3, and 4, respectively. A 60 kDa ECD fragment released by ADAM9, 12, or 17 mediated proteolysis, promotes the proliferation of hematopoietic progenitor cells (2, 3). The residual membrane-bound portion of DLL1 can be cleaved by presenilin-dependent gamma -secretase, enabling the cytoplasmic domain to migrate to the nucleus (4). DLL1 localizes to adherens junctions on neuronal processes through its association with the scaffolding protein MAGI1 (5). DLL1 is widely expressed, and it plays an important role in embryonic somite formation, cochlear hair cell differentiation, plus B and T lymphocyte differentiation (6-11). The upregulation of DLL1 in arterial endothelial cells following injury or angiogenic stimulation is central to postnatal arteriogenesis (12). DLL1 is also overexpressed in cervical carcinoma and glioma and contributes to tumor progression (1, 13). |
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Citations
- Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture.
Authors: Estrach S, Legg J, Watt FM
J. Cell. Sci., 2007;120(0):2944-52.
Species: Human
Sample Type: Cell Lysates
Application: WB
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