抗BDNF抗体(Anti-BDNF, Human, Mouse-Mono, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：27829
BDNFに対する抗体(Anti-BDNF, Human, Mouse-Mono, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年04月27日 00時00分現在]
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Anti-BDNF, Human, Mouse-Mono(37141), Biotin |
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[在庫・価格 ：2025年04月27日 00時00分現在]
Anti-BDNF, Human, Mouse-Mono(37141), Biotin
文献数： 3
- 商品コード：BAM648
- メーカー：RSD
- 包装：50μg
- 価格：¥119,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human BDNF サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB848-500，スタンダードとして#248-BD-005を用いる。 別名：abrineurin クローン：37141 Genbank No： 627 Protein Accession No： P23560 |
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| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Human | 免疫動物 | Mouse |
| 交差性 | Human | 適用 | ELISA |
| 標識 | Biotin | 性状 | Protein A/G Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Monoclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | |||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human |
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| Label | Biotin |
| Immunogen | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human BDNFArg128-Arg247 Accession # P23560 |
| Source | Monoclonal Mouse IgG2A Clone # 37141 |
| Purification | Protein A or G purified from ascites |
| Specificity | Detects human BDNF in ELISAs. In sandwich ELISAs, no cross-reactivity was observed with recombinant human (rh) beta -NGF, rhNT-3, or rhNT-4. |
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Applications and Data
| Recommended Concentration | Sample | |
| Human BDNF Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human BDNF Antibody (Catalog #MAB848 ) |
| ELISA Detection (Matched Antibody Pair) | 0.5-2.0 µg/mL | Human BDNF Biotinylated Antibody (Catalog #BAM648 ) |
| ELISA Standard | Recombinant Human BDNF Protein (Catalog #248-BD ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: BDNF | Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins. All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. Similarly to NGF, bioactive BDNF is predicted to be a non-covalently linked homodimer. BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. The amino acid sequence of mature BDNF is identical in all mammals examined. High levels of expression of BDNF have been detected in the hippocampus, cerebellum, fetal eye and placenta. In addition, low levels of BDNF expression are also found in the pituitary gland, spinal cord, heart, lung and skeletal muscle. BDNF binds with high affinity and specifically activates the TrkB tyrosine kinase receptor. |
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References
| Eide, F.F. et al. (1993) Exp. Neurol. 121:200. | |
| Snider, W.D. (1994) Cell 77:627. | |
| Barbacid, M. (1994) J. Neurobiol. 25:1386. | |
| Long Name: | Brain-derived Neurotrophic Factor |
| Entrez Gene IDs: | 627 (Human); 12064 (Mouse); 24225 (Rat) |
| Alternate Names: | Abrineurin; ANON2; BDNF; brain-derived neurotrophic factor; BULN2; MGC34632; neurotrophin |
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Related Research Areas
| Adult Neurogenesis | ||
| Developmental Factors Implicated in Neurodegeneration | ||
| Diabetes | ||
| Diabetic Peripheral Neuropathy | ||
| Neurotrophic Factors and Receptors | ||
| Neurotrophin/Trk Family | ||
| Obesity | ||
| VPS10P-domain Family | ||
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Related Product & Information
| Background | BDNF |
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| background_content | Background: BDNF Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins. All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. Similarly to NGF, bioactive BDNF is predicted to be a non-covalently linked homodimer.BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. The amino acid sequence of mature BDNF is identical in all mammals examined. High levels of expression of BDNF have been detected in the hippocampus, cerebellum, fetal eye and placenta. In addition, low levels of BDNF expression are also found in the pituitary gland, spinal cord, heart, lung and skeletal muscle. BDNF binds with high affinity and specifically activates the TrkB tyrosine kinase receptor. |
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Citations
- Illness severity and biomarkers in depression: Using a unidimensional rating scale to examine BDNF
Authors: MA Caldieraro, EA Vares, LH Souza, L Spanemberg, TA Guerra, B Wollenhaup, P Ferrari, AA Nierenberg, MP Fleck
Compr Psychiatry, 2017;75(0):46-52.
Species: Human
Sample Type: Serum
Application: ELISA detection - BDNF plasma levels in acute stroke.
Authors: Di Lazzaro V, Profice P, Pilato F, Dileone M, Florio L, Tonali PA, Angelucci F
Neurosci. Lett., 2007;422(2):128-30.
Species: Human
Sample Type: Plasma
Application: ELISA Development
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