抗BMP-6抗体(Anti-BMP-6, Human, Goat-Poly, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：27729
BMP-6に対する抗体(Anti-BMP-6, Human, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年04月26日 20時55分現在]
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[在庫・価格 ：2025年04月26日 20時55分現在]
Anti-BMP-6, Human, Goat-Poly, Biotin
文献数： 2
- 商品コード：BAF507
- メーカー：RSD
- 包装：50μg
- 価格：¥112,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human BMP-6 サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB507-500，スタンダードとして#507-BP-020を用いる。 別名：BMP6 Genbank No： 654 Protein Accession No： P22004 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Human | 免疫動物 | Goat |
| 交差性 | Human | 適用 | ELISA,Western Blot |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | |||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human |
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| Label | Biotin |
| Immunogen | E. coli-derived recombinant human BMP‑6 (R&D Systems, Catalog # 507-BP)Gln382-His513Accession # P22004 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects human BMP-6 in ELISAs and Western blots. In sandwich immunoassays, less than 4% cross-reactivity with recombinant human (rh) BMP‑5 is observed and less than 0.5% cross-reactivity with rhBMP‑2, rhBMP‑4, rhBMP‑7, rhBMP‑8, rhTGF‑ beta 1, rhTGF‑ beta 2, and rhTGF‑ beta 3 is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Human BMP‑6 (Catalog # 507-BP) |
| Human BMP-6 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human BMP‑6 Antibody (Catalog #MAB507 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Human BMP‑6 Biotinylated Antibody (Catalog #BAF507 ) |
| ELISA Standard | Recombinant Human BMP-6 Protein (Catalog #507-BP ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: BMP-6 | Human BMP-6 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor beta (TGF-beta ) superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. However, they have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. Similarly to other TGF-beta family proteins, BMPs are highly conserved across animal species. At the amino acid sequence level, mature human and mouse BMP-6 shares 96% amino acid sequence identity. BMP-6 is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxy-terminal domain. Biologically active BMP-6 is a disulfide-linked homodimer of the carboxy-terminal 132 amino acid residues that contains the characteristic seven conserved cysteine residues involved in the formation of the cysteine knot and the single interchain disulfide bond. Cellular responses to BMP-6 have been shown to be mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. Based on amino acid sequence similarity, BMP-5, -6, -7 and -8 are in the same subgroup. |
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References
| Ebendal, T. et al. (1998) J. Neurosci. Res. 51:139. | |
| Reddi, A.H. (1998) Nature Biotechnology 16:247. | |
| Long Name: | Bone Morphogenetic Protein 6 |
| Entrez Gene IDs: | 654 (Human); 12161 (Mouse); 25644 (Rat) |
| Alternate Names: | BMP6; BMP-6; bone morphogenetic protein 6; vegetal related growth factor (TGFB-related); vegetal-related (TGFB related) cytokine; VG-1-R; VG-1-related protein; Vg1-related sequence; VGR; VGR1; Vgr-1 |
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Related Research Areas
| BMP Family | ||
| BMPs (Bone Morphogenetic Proteins) | ||
| Early Mesodermal Lineage Markers | ||
| Molecules Secreted by VSMC | ||
| Negative Regulators of EMT | ||
| TGF-beta Superfamily | ||
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Related Product & Information
| Background | BMP-6 |
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| background_content | Background: BMP-6 Human BMP-6 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor beta (TGF-beta ) superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. However, they have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. Similarly to other TGF-beta family proteins, BMPs are highly conserved across animal species. At the amino acid sequence level, mature human and mouse BMP-6 shares 96% amino acid sequence identity. BMP-6 is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxy-terminal domain. Biologically active BMP-6 is a disulfide-linked homodimer of the carboxy-terminal 132 amino acid residues that contains the characteristic seven conserved cysteine residues involved in the formation of the cysteine knot and the single interchain disulfide bond. Cellular responses to BMP-6 have been shown to be mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. Based on amino acid sequence similarity, BMP-5, -6, -7 and -8 are in the same subgroup. |
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Citations
- Induction of osteogenic differentiation of adipose derived stem cells by microstructured nitinol actuator-mediated mechanical stress.
Authors: Strauss S, Dudziak S, Hagemann R, Barcikowski S, Fliess M, Israelowitz M, Kracht D, Kuhbier J, Radtke C, Reimers K, Vogt P
PLoS ONE, 2102;7(12):e51264.
Species: Human
Sample Type: Whole Cells
Application: ICC - The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis.
Authors: Martinez V, Sacedon R, Hidalgo L, Valencia J, Fernandez-Sevilla L, Hernandez-Lopez C, Vicente A, Varas A
PLoS ONE, 2015;10(6):e0131453.
Species: Human
Sample Type: Whole Cells
Application: Flow
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