抗BLC抗体(Anti-BLC, Mouse, Goat-Poly, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：27696
BLCに対する抗体(Anti-BLC, Mouse, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年04月26日 20時35分現在]
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Anti-BLC, Mouse, Goat-Poly, Biotin <Anti-BCA-1> |
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[在庫・価格 ：2025年04月26日 20時35分現在]
Anti-BLC, Mouse, Goat-Poly, Biotin <Anti-BCA-1>
文献数： 6
- 商品コード：BAF470
- メーカー：RSD
- 包装：50μg
- 価格：¥119,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Mouse CXCL13/BLC/BCA-1 サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB470-500または#MAB470R-100，スタンダードとして#470-BC-025を用いる。 別名：ANGIE Genbank No： 10563 Protein Accession No： Q3U1E8 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Mouse | 免疫動物 | Goat |
| 交差性 | Mouse | 適用 | ELISA,Western Blot |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | |||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Mouse |
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| Label | Biotin |
| Immunogen | E. coli-derived recombinant mouse CXCL13/BLC (R&D Systems, Catalog # 470-BC)Ile22-Ala109Accession # Q3U1E8 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects mouse CXCL13 in ELISAs and Western blots. In sandwich immunoassays, less than 0.05% cross-reactivity with recombinant human CXCL13, recombinant mouse (rm) I-TAC, rmMIG, and rmSDF-1 alpha is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Mouse CXCL13/BLC/BCA‑1 (Catalog # 470-BC) |
| Mouse CXCL13/BLC/BCA-1 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Mouse CXCL13/BLC/BCA‑1 Antibody (Catalog #MAB470R ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse CXCL13/BLC/BCA‑1 Biotinylated Antibody (Catalog #BAF470 ) |
| ELISA Standard | Recombinant Mouse CXCL13/BLC/BCA-1 Protein (Catalog #470-BC ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: CXCL13/BLC/BCA-1 | CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Mouse BCA-1 cDNA encodes a precursor protein of 109 amino acid residues with a putative leader sequence of 21 residues. Mature mouse BCA-1 shares 64% amino acid sequence similarity with the human protein and 23 - 34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA-1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for BCA-1. Among cells of the hematopoietic lineages, the expression of BLR1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. Mice lacking BLR1 have been shown to lack inguinal lymph nodes. These mice were also found to have impaired development of Peyer’s patches and defective formation of primary follicles and germinal centers in the spleen as a result of the inability of B lymphocytes to migrate into B cell areas. |
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References
| Gunn, M.D. et al. (1998) Nature, 391:799. | |
| Legler, D.F. et al. (1998) J. Exp. Med. 187:655. | |
| Forster, R. et al. (1996) Cell 87:1037. | |
| Entrez Gene IDs: | 10563 (Human); 55985 (Mouse) |
| Alternate Names: | ANGIE; ANGIE2; B cell-attracting chemokine 1; B lymphocyte chemoattractant; BCA1; BCA-1; BCA1B-cell chemoattractant; BCA-1CXC chemokine BLC; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); BLC; BLCSmall-inducible cytokine B13; BLR1L; B-lymphocyte chemoattractant; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); chemokine (C-X-C motif) ligand 13; C-X-C motif chemokine 13; CXCL13; SCYB13B-cell-attracting chemokine 1; small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant) |
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Related Research Areas
| B Cell Chemotaxis, Migration, and Adhesion | ||
| Chemokines and Receptors | ||
| Chemokines and Receptors in Angiogenesis | ||
| Chemokines and Receptors in Tfh Cell Differentiation and Function | ||
| CXC Chemokines and Receptors | ||
| gamma delta T Cells | ||
| Macrophage Activation Markers | ||
| Molecules Secreted by VSMC | ||
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Related Product & Information
| Background | CXCL13/BLC/BCA-1 |
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| background_content | Background: CXCL13/BLC/BCA-1 CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Mouse BCA-1 cDNA encodes a precursor protein of 109 amino acid residues with a putative leader sequence of 21 residues. Mature mouse BCA-1 shares 64% amino acid sequence similarity with the human protein and 23 - 34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA-1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for BCA-1. Among cells of the hematopoietic lineages, the expression of BLR1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. Mice lacking BLR1 have been shown to lack inguinal lymph nodes. These mice were also found to have impaired development of Peyer’s patches and defective formation of primary follicles and germinal centers in the spleen as a result of the inability of B lymphocytes to migrate into B cell areas. |
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Citations
- Peyer's patch inducer cells play a leading role in the formation of B and T cell zone architecture.
Authors: Nakagawa R, Togawa A, Nagasawa T, Nishikawa S
J Immunol, 2013;190(7):3309-18.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Fluorescence - Colonic patch and colonic SILT development are independent and differentially regulated events.
Authors: Baptista A, Olivier B, Goverse G, Greuter M, Knippenberg M, Kusser K, Domingues R, Veiga-Fernandes H, Luster A, Lugering A, Randall T, Cupedo T, Mebius R
Mucosal Immunol, 2013;6(3):511-21.
Species: Mouse
Sample Type: Whole Tissue
Application: IF - Response patterns of cytokines/chemokines in two murine strains after irradiation.
Authors: Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, Salzman P, Wang W, Liu C, Vidyasagar S, Zhang L, Ju S, Okunieff P, Zhang L
Cytokine, 2012;58(2):169-77.
Species: Mouse
Sample Type: Plasma
Application: Luminex Assay Development - Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs.
Authors: Katakai T, Suto H, Sugai M, Gonda H, Togawa A, Suematsu S, Ebisuno Y, Katagiri K, Kinashi T, Shimizu A
J. Immunol., 2008;181(9):6189-200.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Frozen
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