抗Eotaxin-3抗体(Anti-Eotaxin-3, Human, Goat-Poly, Biotin antibody)

• 2025/12/01

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  [RSD]厳選 抗体＆リコンビナントタンパク質 30％OFFキャンペーン[～2026/02/27] NEW

  期間：2025/12/01 ～2026/02/27

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  R&D Systems, Inc.（RSD）

• 価格
• Product Details
• Applications and Data
• References
• Related Research Areas
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Biotin
Immunogen	E. coli-derived recombinant human CCL26/Eotaxin-3 (R&D Systems, Catalog # 346-E3)Thr24-Leu94Accession # Q9Y258
Source	Polyclonal Goat IgG
Purification	Antigen Affinity-purified
Specificity	Detects human CCL26/Eotaxin-3 in ELISAs and Western blots. In sandwich immunoassays, less than 0.5% cross-reactivity with recombinant human (rh) Eotaxin, rhEotaxin‑2, recombinant mouse (rm) Eotaxin, and rmEotaxin‑2 is observed.

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Applications and Data

	Recommended Concentration	Sample
Western Blot	0.1 µg/mL	Recombinant Human CCL26/Eotaxin‑3 (Catalog # 346-E3)
Human CCL26/Eotaxin-3 Sandwich Immunoassay	Reagent
ELISA Capture (Matched Antibody Pair)	2-8 µg/mL	Human CCL26/Eotaxin‑3 Antibody (Catalog #MAB653 )
ELISA Detection (Matched Antibody Pair)	0.1-0.4 µg/mL	Human CCL26/Eotaxin‑3 Biotinylated Antibody (Catalog #BAF346 )
ELISA Standard		Recombinant Human CCL26/Eotaxin-3 Protein (Catalog #653-E3 )
Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website.		Preparation and Storage
Reconstitution	Reconstitute at 0.2 mg/mL in sterile PBS.	Reconstitution Buffer Available
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CCL26/Eotaxin-3	Eotaxin-3, also named CCL26 or SCYA26, is a novel human CC chemokine that maps to chromosome 7q11.2, within 40 kilobases of the Eotaxin-2 loci. Eotaxin-3/CCL26 has been shown to be constitutively expressed in the heart and ovary. In addition, low levels of Eotaxin-3/CCL26 expression can also be detected in various tissues. The expression of Eotaxin-3/CCL26 in vascular endothelial cells has been shown to be up-regulated by IL-13 and IL-4. Eotaxin-3/CCL26 cDNA encodes a 94 amino acid (aa) residue protein with a putative signal peptide of either 23 or 26 aa residues. Eotaxin-3/CCL26 induces calcium flux in eosinophils as well as in CCR3-transfected cells. Eotaxin-3/CCL26 has also been shown to cross-desensitize cells to other CCR3 ligands.

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References

Gou, R.F. et al. (1999) Genomics 58:313.
Kitamura, M. et al. (1999) J. Biol. Chem. 274:27975.
Shinkai, A. et al. (1999) J. Immunol. 163:1602.
Entrez Gene IDs:	10344 (Human)
Alternate Names:	CC chemokine IMAC; C-C motif chemokine 26; CCL26; chemokine (C-C motif) ligand 26; chemokine N1; Eotaxin3; Eotaxin-3; IMAC; Macrophage inflammatory protein 4-alpha; MGC126714; MIP-4a; MIP-4alpha; SCYA26; SCYA26MIP-4-alpha; small inducible cytokine A26; small inducible cytokine subfamily A (Cys-Cys), member 26; Small-inducible cytokine A26; TSC-1Thymic stroma chemokine-1

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Related Research Areas

CC Chemokines and Receptors

Chemokines and Receptors

Chemokines and Receptors in Allergy and Asthma

Macrophage Activation Markers

Chronic aeroallergen during infancy enhances eotaxin-3 expression in airway epithelium and nerves. Authors: Chou DL, Daugherty BL, McKenna EK, Hsu WM, Tyler NK, Plopper CG, Hyde DM, Schelegle ES, Gershwin LJ, Miller LA Am. J. Respir. Cell Mol. Biol., 2005;33(1):1-8. Species: Primate - Macaca mulatta (Rhesus Macaque) Sample Type: Whole Tissue Application: IHC

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Related Product & Information

Background

CCL26/Eotaxin-3

background_content

Background: CCL26/Eotaxin-3 Eotaxin-3, also named CCL26 or SCYA26, is a novel human CC chemokine that maps to chromosome 7q11.2, within 40 kilobases of the Eotaxin-2 loci. Eotaxin-3/CCL26 has been shown to be constitutively expressed in the heart and ovary. In addition, low levels of Eotaxin-3/CCL26 expression can also be detected in various tissues. The expression of Eotaxin-3/CCL26 in vascular endothelial cells has been shown to be up-regulated by IL-13 and IL-4. Eotaxin-3/CCL26 cDNA encodes a 94 amino acid (aa) residue protein with a putative signal peptide of either 23 or 26 aa residues. Eotaxin-3/CCL26 induces calcium flux in eosinophils as well as in CCR3-transfected cells. Eotaxin-3/CCL26 has also been shown to cross-desensitize cells to other CCR3 ligands.

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Citations

1. Chronic aeroallergen during infancy enhances eotaxin-3 expression in airway epithelium and nerves.
   Authors: Chou DL, Daugherty BL, McKenna EK, Hsu WM, Tyler NK, Plopper CG, Hyde DM, Schelegle ES, Gershwin LJ, Miller LA
   Am. J. Respir. Cell Mol. Biol., 2005;33(1):1-8.
   Species: Primate - Macaca mulatta (Rhesus Macaque)
   Sample Type: Whole Tissue
   Application: IHC


2. Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments.
   Authors: Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G
   Blood, 2004;104(2):314-20.
   Species: Human
   Sample Type: Cell Culture Supernates
   Application: ELISA Development

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