抗IGF-Ⅰ抗体(Anti-IGF-Ⅰ, Human, Goat-Poly, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：27558
IGF-Ⅰに対する抗体(Anti-IGF-Ⅰ, Human, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年05月13日 18時55分現在]
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Anti-IGF-I/IGF-1, Human, Goat-Poly, Biotin |
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[在庫・価格 ：2025年05月13日 18時55分現在]
Anti-IGF-I/IGF-1, Human, Goat-Poly, Biotin
文献数： 8
- 商品コード：BAF291
- メーカー：RSD
- 包装：50μg
- 価格：¥120,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human IGF-I サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB291-500，スタンダードとして#291-G1-200を用いる。 別名：IBP1 Genbank No： 3479 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Human | 免疫動物 | Goat |
| 交差性 | Human | 適用 | ELISA,Western Blot |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | R&D Systems社のIGF-Ⅰ関連抗体 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human |
|---|---|
| Label | Biotin |
| Immunogen | E. coli-derived recombinant human IGF-I |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects human IGF-I in ELISAs and Western blots. In sandwich immunoassays, less than 0.1% recombinant human (rh) IGF‑I sR, recombinant mouse (rm) IGF‑I, rmIGF‑II, rhIGF-II, rhIGFBP-1, rhIGFBP-2, rhIGFBP-3, rhIGFBP-4, rhIGFBP-5, and rhIGFBP-6 is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Human IGF-I (Catalog # 291-G1) |
| Human IGF-I Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human IGF‑I Antibody (Catalog #MAB291 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Human IGF‑I Biotinylated Antibody (Catalog #BAF291 ) |
| ELISA Standard | Recombinant Human IGF-I Protein, CF (Catalog #291-G1 ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: IGF-I | Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF-I is synthesized as two precursor isoforms with N- and alternate C-terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-I is identical between isoforms and is generated by proteolytic removal of the N- and C-terminal regions. Mature human IGF-I shares 94% and 96% aa sequence identity with mouse and rat IGF-I, respectively (2), and exhibits cross-species activity. It shares 64% aa sequence identity with mature human IGF-II. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects (1). IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4 - 7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). IGF-I association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors (10). |
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References
| Philippou, A. et al. (2007) In Vivo 21:45. | |
| Sandberg-Nordqvist, A.C. et al. (1992) Brain Res. Mol. Brain Res. 12:275. | |
| Guvakova, M.A. (2007) Int. J. Biochem. Cell Biol. 39:890. | |
| Clemmons, D.R. (2006) Curr. Opin. Pharmacol. 6:620. | |
| Bluher, S. et al. (2005) Best Pract. Res. Clin. Endocrinol. Metab. 19:577. | |
| Garcia-Segura, L.M. et al. (2006) Neuroendocrinology 84:275. | |
| Malemud, C.J. (2007) Clin. Chim. Acta 375:10. | |
| Samani, A.A. et al. (2007) Endocrine Rev. 28:20. | |
| LeRoith, D. and S. Yakar (2007) Nat. Clin. Pract. Endocrinol. Metab. 3:302. | |
| Denley, A. et al. (2005) Cytokine Growth Factor Rev. 16:421. | |
| Long Name: | Insulin-like Growth Factor I |
| Entrez Gene IDs: | 3479 (Human); 16000 (Mouse); 24482 (Rat) |
| Alternate Names: | IBP1; IGF1; IGF-1; IGF1A; IGFI; IGF-I; IGF-IA; IGF-IB; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; Mechano growth factor; MGF; Somatomedin A; Somatomedin C; somatomedin-C |
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Related Research Areas
| Alpha Granule Soluble Molecules | ||
| ALS Related Molecules | ||
| Cancer Biomarkers | ||
| Diabetes and Obesity Research | ||
| Endocrine Regulation of Lipid Metabolism | ||
| gamma delta T Cells | ||
| Glucose Homeostasis | ||
| IGF Family | ||
| IGF Ligands | ||
| Metabolic Peptide Hormones and Regulators | ||
| Preeclampsia | ||
| Protein/Peptide Hormones and Regulators | ||
| Reproduction | ||
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Related Product & Information
| Background | IGF-I |
|---|---|
| background_content | Background: IGF-I Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF-I is synthesized as two precursor isoforms with N- and alternate C-terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-I is identical between isoforms and is generated by proteolytic removal of the N- and C-terminal regions. Mature human IGF-I shares 94% and 96% aa sequence identity with mouse and rat IGF-I, respectively (2), and exhibits cross-species activity. It shares 64% aa sequence identity with mature human IGF-II. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects (1). IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4 - 7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). IGF-I association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors (10). |
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Citations
- Calling Biomarkers in Milk Using a Protein Microarray on Your Smartphone.
Authors: Ludwig S, Tokarski C, Lang S, van Ginkel L, Zhu H, Ozcan A, Nielen M
PLoS ONE, 2015;10(8):e0134360.
Species: Bovine
Sample Type: Milk
Application: Microarray - ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence.
Authors: Luo X, Suzuki M, Ghandhi S, Amundson S, Boothman D
PLoS ONE, 2014;9(6):e99983.
Species: Human
Sample Type: Cell Culture Supernates
Application: ELISA detection - Development and validation of sandwich ELISA microarrays with minimal assay interference.
Authors: Gonzalez RM, Seurynck-Servoss SL, Crowley SA
J. Proteome Res., 2008;7(6):2406-14.
Species: Human
Sample Type: Serum
Application: ELISA Microarray Development - Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy.
Authors: Yin D, Vreeland F, Schaaf LJ, Millham R, Duncan BA, Sharma A
Clin. Cancer Res., 2007;13(3):1000-9.
Species: Human
Sample Type: Plasma
Application: ELISA Development
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