抗IL-18 Receptor抗体(Anti-IL-18 Receptor, Mouse, Goat-Poly antibody)
掲載日情報:2018/11/26 現在Webページ番号:27341
IL-18 Receptorに対する抗体(Anti-IL-18 Receptor, Mouse, Goat-Poly )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2025年02月14日 20時15分現在]
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Anti-IL-18 Receptor, Mouse, Goat-Poly |
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Anti-Mouse IL-18 R alpha/IL-1 R5 Affinity Purified Polyclonal Ab |
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[在庫・価格 :2025年02月14日 20時15分現在]
Anti-IL-18 Receptor, Mouse, Goat-Poly
文献数: 19
- 商品コード:AF856
- メーカー:RSD
- 包装:100μg
- 価格:¥100,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 別名:IL-18 R alpha,IL-1 R5 Genbank No: 8809 Protein Accession No: Q61098 |
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別包装品 | 別包装品あり | ||||||
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保存条件 | -20℃ | 法規備考 | |||||
抗原種 | Mouse | 免疫動物 | Goat | ||||
交差性 | Mouse | 適用 | FCM,Neutralising,Western Blot | ||||
標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Polyclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | Helper T Cells Marker Antibodies |
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関連記事 |
Anti-Mouse IL-18 R alpha/IL-1 R5 Affinity Purified Polyclonal Ab
文献数: 1
- 商品コード:AF856-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥30,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | ※受注発注品。形状:溶液または凍結乾燥 Genbank No: 8809 Protein Accession No: Q61098 |
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別包装品 | 別包装品あり | ||||||
法規制等 | |||||||
保存条件 | -20℃ | 法規備考 | |||||
抗原種 | 免疫動物 | Goat | |||||
交差性 | Mouse | 適用 | FCM,Neutralising,Western Blot | ||||
標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Polyclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | Helper T Cells Marker Antibodies 使いっきり抗体 |
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関連記事 |
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Product Details
Species Reactivity | Mouse |
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Label | Unconjugated |
Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse IL‑18 R alpha /IL-1 R5Ser19-Gly326Accession # Q61098 |
Source | Polyclonal Goat IgG |
Purification | Antigen Affinity-purified |
Specificity | Detects mouse IL‑18 R alpha in direct ELISAs and Western blots. In direct ELISAs, approximately 25% cross-reactivity with recombinant human IL‑18 R is observed. |
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Applications and Data
Recommended Concentration | Sample | |
Western Blot | 0.1 µg/mL | Recombinant Mouse IL‑18 R alpha /IL‑1 R5 |
Flow Cytometry | 2.5 µg/106 cells | Mouse splenocytes or EL-4/IL-2 cells |
CyTOF-ready | Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation. | |
Neutralization | Measured by its ability to neutralize IL‑18/IL‑1F4-induced IFN‑ gamma secretion in activated mouse T cells. Ahn, H.J. et al. (1997) J. Immunol. 159:2125. The Neutralization Dose (ND50) is typically 0.2-0.8 µg/mL in the presence of 0.5 ng/mL Recombinant Mouse IL‑18/IL‑1F4 and 0.1 ng/mL Recombinant Mouse IL‑12. |
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Related Product & Information
Long Name | Interleukin 18 Receptor alpha |
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Entrez Gene IDs | 8809 (Human); 16182 (Mouse) |
Background | IL-18 R alpha/IL-1 R5 |
background_content | Background: IL-18 R alpha/IL-1 R5 Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immuno-regulatory functions with IL-12. The functional IL-18 receptor complex is composed of two subunits designated IL18 R alpha (also termed IL-1 R5 and IL-1 Rrp) and IL-18 R beta (also termed IL-1 R7 and AcPL). Both IL-18 R alpha and IL-18 R beta belong to the IL-1 receptor superfamily. Although IL-18 R by itself binds IL-18 with low affinity and IL-18 R beta does not bind IL18 in vitro, coexpression of IL-18 R alpha and IL18 R beta is required for high affinity binding and IL-18 responsiveness. Human IL-18 R cDNA encodes a 541 amino acid (aa) precursor type I membrane protein with a hydrophobic signal, an extracellular domain comprised of three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic region of approximately 200 aa residues. Human and mouse IL-18 R share 65% amino acid sequence homology. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta. |
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Citations
- Interleukin-18 and its receptor are expressed in gonadotropin-releasing hormone neurons of mouse and rat forebrain
Authors: S Kuwahara-O, S Maeda, K Kobayashi, Y Minato, K Tanaka, K Yamanishi, M Hata, W Li, T Hayakawa, K Noguchi, H Okamura, H Yagi
Neurosci. Lett., 2017;0(0):. - Increased cytokine production in IL-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling (SOCS).
Authors: Nold-Petry CA, Nold MF, Nielsen JW, Bustamante A, Zepp JA, Storm KA, Hong JW, Kim SH, Dinarello CA
J. Biol. Chem., 2009;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Neut - IL-18 induces a marked gene expression profile change and increased Ccl1 (I-309) production in mouse mucosal mast cell homologs.
Authors: Wiener Z, Pocza P, Racz M, Nagy G, Tolgyesi G, Molnar V, Jaeger J, Buzas E, Gorbe E, Papp Z, Rigo J, Falus A
Int. Immunol., 2008;20(12):1565-73.
Species: Mouse
Sample Type: Whole Cells
Application: Flow - Protective effect of IL-18 on kainate- and IL-1beta-induced cerebellar ataxia in mice.
Authors: Andoh T, Kishi H, Motoki K, Nakanishi K, Kuraishi Y, Muraguchi A
J. Immunol., 2008;180(4):2322-8.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Frozen - Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation.
Authors: Chandrasekar B, Patel DN, Mummidi S, Kim JW, Clark RA, Valente AJ
J. Biol. Chem., 2007;283(7):4200-9.
Species: Mouse
Sample Type: Whole Cells
Application: Flow - Disruption of interleukin-18, but not interleukin-1, increases vulnerability to preterm delivery and fetal mortality after intrauterine inflammation.
Authors: Wang X, Hagberg H, Mallard C, Zhu C, Hedtjarn M, Tiger CF, Eriksson K, Rosen A, Jacobsson B
Am. J. Pathol., 2006;169(3):967-76.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Frozen - Combined stimulation with interleukin-18 and CpG induces murine natural killer dendritic cells to produce IFN-gamma and inhibit tumor growth.
Authors: Chaudhry UI, Kingham TP, Plitas G, Katz SC, Raab JR, DeMatteo RP
Cancer Res., 2006;66(21):10497-504.
Species: Mouse
Sample Type: Whole Cells
Application: Flow - Distinct modulatory effects of LPS and CpG on IL-18-dependent IFN-gamma synthesis.
Authors: Gould MP, Greene JA, Bhoj V, DeVecchio JL, Heinzel FP
J. Immunol., 2004;172(3):1754-62.
Species: Mouse
Sample Type: Whole Cells
Application: Neut
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