抗I-TAC抗体(Anti-I-TAC, Mouse, Goat-Poly antibody)
掲載日情報：2021/01/28 現在Webページ番号：27122
I-TACに対する抗体(Anti-I-TAC, Mouse, Goat-Poly )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- Data Examples
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年04月26日 20時55分現在]
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Anti-I-TAC, Mouse, Goat-Poly <Anti-CXCL11> |
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Anti-Mouse CXCL11/I-TAC Affinity Purified Polyclonal Ab |
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[在庫・価格 ：2025年04月26日 20時55分現在]
Anti-I-TAC, Mouse, Goat-Poly <Anti-CXCL11>
文献数： 4
- 商品コード：AF572
- メーカー：RSD
- 包装：100μg
- 価格：¥105,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Mouse CXCL11/I-TAC サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAF572，スタンダードとして#572-MC-025を用いる。 別名：beta-R1 Genbank No： 6373 Protein Accession No： Q9JHH5 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | Mouse | 免疫動物 | Goat | ||||
| 交差性 | Mouse | 適用 | ELISA,Neutralising,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Polyclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | M1/M2 Macrophage Activation Marker |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Mouse CXCL11/I-TAC Affinity Purified Polyclonal Ab
文献数： 0
- 商品コード：AF572-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：beta-R1 Genbank No： 6373 Protein Accession No： Q9JHH5 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Goat | |||||
| 交差性 | Mouse | 適用 | ELISA,Neutralising,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Polyclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | M1/M2 Macrophage Activation Marker 使いっきり抗体 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Mouse |
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| Label | Unconjugated |
| Immunogen | E. coli-derived recombinant mouse CXCL11/I-TACPhe22-Met100Accession # Q9JHH5 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects mouse CXCL11/I-TAC in ELISAs and Western blots. In sandwich ELISAs, less than 0.2% cross-reactivity with recombinant human CXCL11, recombinant mouse (rm) BLC, rmCRG‑2, rmGCP‑2, rmMIG, rmPF4, and rmSDF‑1 alpha is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Mouse CXCL11/I-TAC (Catalog # 572-MC) |
| Mouse CXCL11/I-TAC Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 0.2-0.8 µg/mL | Mouse CXCL11/I‑TAC Antibody (Catalog #AF572 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse CXCL11/I‑TAC Biotinylated Antibody (Catalog #BAF572 ) |
| ELISA Standard | Recombinant Mouse CXCL11/I-TAC Protein (Catalog #572-MC ) | |
| Neutralization | Measured by its ability to neutralize CXCL11/I‑TAC-induced chemotaxis in the BaF3 mouse pro‑B cell line transfected with human CXCR3. The Neutralization Dose (ND50) is typically 2-12 µg/mL in the presence of 200 ng/mL Recombinant Mouse CXCL11/I‑TAC. | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | ||
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Data Examples
| Neutralization |
![Neutralization CXCL11/I-TAC Antibody [Unconjugated]](http://resources.rndsystems.com/images/datasheets/antibody/CXCL11_AF572_Block_Neutralize_8927.jpg) click image to view larger | Chemotaxis Induced by CXCL11/I‑TAC and Neutralization by Mouse CXCL11/I‑TAC Antibody.Recombinant Mouse CXCL11/I‑TAC (Catalog # 572-MC) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR3 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Mouse CXCL11/ I‑TAC (200 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse CXCL11/I-TAC Antigen Affinity-purified Polyclonal Antibody (Catalog # AF572). The ND50 is typically 2-12 µg/mL. |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: CXCL11/I-TAC | CXCL11 (also known as I-TAC, SCYB9B, H174, IP-9, and beta -R1) is a member within the non-ELR CXC chemokine subgroup and has been designated CXCL11. CXCL11, together with MIG and IP-10, constitute a subset of chemokines that are ligands for CXCR3, a chemokine receptor that is primarily expressed on activated Th1 cells and NK cells. The three chemokines were also reported to act as antagonists for CCR3, a chemokine receptor that is preferentially expressed on activated Th2 cells. Mouse CXCL11 cDNA encodes a 100 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide that is cleaved to yield a 79 aa residue mature protein. Mature mouse and human CXCL11 share 71% aa sequence identity. Mouse CXCL11 also shares 36% and 29% aa sequence identity with mouse IP-10 (CRG-2) and mouse MIG, respectively. The gene for mouse CXCL11 has been mapped to chromosome 5, in close proximity to the IP-10 and MIG genes. Mouse CXCL11 is induced in multiple tissues during endoxemia, with the greatest expression in lung, heart, small intestine, and kidney. The endotoxemia-induced mouse CXCL11 expression is strongly attenuated by treatment with glucocorticoid. |
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References
| Widney, D.P. et al. (2000) J. Immunol. 164:6322. | |
| Meyer, M. et al. (2000) Cytogenet. Cell Genet. 88:278. | |
| Loetscher, P. et al. (2001) J. Biol. Chem. Manuscript M005652200. | |
| Entrez Gene IDs: | 6373 (Human); 56066 (Mouse) |
| Alternate Names: | beta-R1; b-R1; chemokine (C-X-C motif) ligand 11; CXCL11; H174; H174IP9; Interferon gamma-inducible protein 9; Interferon-inducible T-cell alpha chemoattractant; IP-9member 11; ITAC; I-TAC; I-TACMGC102770; SCYB9B; small inducible cytokine subfamily B (Cys-X-Cys), member 9B; Small-inducible cytokine B11 |
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Related Research Areas
| Chemokines and Receptors | ||
| Chemokines and Receptors in Angiogenesis | ||
| CXC Chemokines and Receptors | ||
| Macrophage Activation Markers | ||
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| Neutralization | |
|---|---|
 | Chemotaxis Induced by CXCL11/I‑TAC and Neutralization by Mouse CXCL11/I‑TAC Antibody. Recombinant MouseCXCL11/I‑TAC (Catalog #572-MC) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR3 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Mouse CXCL11/I‑TAC (200 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse CXCL11/I-TAC Antigen Affinity-purified Polyclonal Antibody (Catalog # AF572). The ND50 is typically 2-12 µg/mL. |
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Related Product & Information
| Entrez Gene IDs | 6373 (Human); 56066 (Mouse) |
|---|---|
| Background | CXCL11/I-TAC |
| background_content | Background: CXCL11/I-TAC CXCL11 (also known as I-TAC, SCYB9B, H174, IP-9, and beta -R1) is a member within the non-ELR CXC chemokine subgroup and has been designated CXCL11. CXCL11, together with MIG and IP-10, constitute a subset of chemokines that are ligands for CXCR3, a chemokine receptor that is primarily expressed on activated Th1 cells and NK cells. The three chemokines were also reported to act as antagonists for CCR3, a chemokine receptor that is preferentially expressed on activated Th2 cells. Mouse CXCL11 cDNA encodes a 100 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide that is cleaved to yield a 79 aa residue mature protein. Mature mouse and human CXCL11 share 71% aa sequence identity. Mouse CXCL11 also shares 36% and 29% aa sequence identity with mouse IP-10 (CRG-2) and mouse MIG, respectively. The gene for mouse CXCL11 has been mapped to chromosome 5, in close proximity to the IP-10 and MIG genes. Mouse CXCL11 is induced in multiple tissues during endoxemia, with the greatest expression in lung, heart, small intestine, and kidney. The endotoxemia-induced mouse CXCL11 expression is strongly attenuated by treatment with glucocorticoid. |
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Citations
- Sensing and alarm function of resident memory CD8(+) T cells.
Authors: Schenkel J, Fraser K, Vezys V, Masopust D
Nat Immunol, 2013;14(5):509-13.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC - Comprehensive assessment of chemokine expression profiles by flow cytometry.
Authors: Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D
J. Clin. Invest., 2010;120(3):907-23.
Species: Mouse
Sample Type: Whole Cells
Application: Flow
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