抗IL-18抗体(Anti-IL-18, Rat, Goat-Poly antibody)
掲載日情報:2019/10/21 現在Webページ番号:27080
IL-18に対する抗体(Anti-IL-18, Rat, Goat-Poly )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2025年02月14日 20時35分現在]
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Anti-IL-18, Rat, Goat-Poly |
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Anti-Rat IL-18/IL-1F4 Affinity Purified Polyclonal Ab |
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[在庫・価格 :2025年02月14日 20時35分現在]
Anti-IL-18, Rat, Goat-Poly
文献数: 10
- 商品コード:AF521
- メーカー:RSD
- 包装:100μg
- 価格:¥107,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 別名:Iboctadekin Genbank No: 3606 Protein Accession No: P97636 |
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別包装品 | 別包装品あり | ||||||
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保存条件 | -20℃ | 法規備考 | |||||
抗原種 | Rat | 免疫動物 | Goat | ||||
交差性 | Rat | 適用 | Neutralising,Western Blot | ||||
標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Polyclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | M1/M2 Macrophage Activation Marker Helper T Cells Marker Antibodies |
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関連記事 |
Anti-Rat IL-18/IL-1F4 Affinity Purified Polyclonal Ab
文献数: 0
- 商品コード:AF521-SP
- メーカー:RSD
- 包装:25μg
- 価格:¥30,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | ※受注発注品。形状:溶液または凍結乾燥 別名:Iboctadekin Genbank No: 3606 Protein Accession No: P97636 |
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別包装品 | 別包装品あり | ||||||
法規制等 | |||||||
保存条件 | 法規備考 | ||||||
抗原種 | 免疫動物 | Goat | |||||
交差性 | Rat | 適用 | Neutralising,Western Blot | ||||
標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
吸収処理 | クラス | IgG | |||||
クロナリティ | Polyclonal | フォーマット | |||||
掲載カタログ |
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製品記事 | M1/M2 Macrophage Activation Marker Helper T Cells Marker Antibodies 使いっきり抗体 |
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関連記事 |
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Product Details
Species Reactivity | Rat |
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Label | Unconjugated |
Immunogen | E. coli-derived recombinant rat IL‑18/IL-1F4His37-Ser194Accession # P97636 |
Source | Polyclonal Goat IgG |
Purification | Antigen Affinity-purified |
Specificity | Detects rat IL‑18/IL-1F4 in direct ELISAs and Western blots. In Western blots, approximately 35% cross-reactivity with recombinant mouse IL‑18 is observed and approximately 10% cross-reactivity with recombinant human IL‑18 is observed. |
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Applications and Data
Recommended Concentration | Sample | |
Western Blot | 0.1 µg/mL | Recombinant Rat IL‑18/IL‑1F4 (Catalog # 521-RL) |
Neutralization | Measured by its ability to neutralize IL‑18/IL‑1F4-induced IFN‑ gamma secretion in activated mouse T cells [Ahn, H.J. et al. (1997) J. Immunol. 159:2125]. The Neutralization Dose (ND50) is typically 1-3 µg/mL in the presence of 15 ng/mL Recombinant Rat IL‑18/IL‑1F4 and 0.1 ng/mL Recombinant Mouse IL‑12. |
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Related Product & Information
Long Name | Interleukin 18 |
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Entrez Gene IDs | 3606 (Human); 16173 (Mouse); 29197 (Rat); 397057 (Porcine); 574151 (Primate) |
Background | IL-18/IL-1F4 |
background_content | Background: IL-18/IL-1F4 Interleukin-18 (IL-18), also known as IL-1F4 and IFN-gamma inducing factor (IGIF), is a member of the IL-1 family of cytokines and is a key molecule in the innate immune response (1). Rat IL-18 is synthesized as a 24 kDa proprotein that contains a 36 amino acid (aa) propeptide and a 158 aa mature region (2). Under inflammatory conditions, the propeptide is cleaved by Caspase-1 in the cytoplasm to liberate the mature nonglycosylated 18 kDa monomeric IL-18 (3, 4). Mature rat IL-18 shares 91% aa sequence identity with mouse IL-18 and 60-64% aa sequence identity with human, canine, feline, porcine, and rhesus macaque IL-18. IL-18 is secreted by a variety of cell types including macrophages, dendritic cells, and epithelial cells (1, 5). Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity (6). IL-18 interacts with the widely expressed IL-18 R alpha which then recruits the signaling subunit IL-18 R beta (7, 8). The IL-1 family member IL-1F7 also binds to IL-18 R alpha but does not recruit IL-18 R beta or induce signaling (9). IL-1F7 binds IL-18 BP and enhances its neutralizing effect on IL-18 activity (9). IL-18 synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma (1, 5, 10-12). IL-18 can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses (13, 14). Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome (1, 5, 15, 16). In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion (11). |
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Citations
- Interleukin-18 and its receptor are expressed in gonadotropin-releasing hormone neurons of mouse and rat forebrain
Authors: S Kuwahara-O, S Maeda, K Kobayashi, Y Minato, K Tanaka, K Yamanishi, M Hata, W Li, T Hayakawa, K Noguchi, H Okamura, H Yagi
Neurosci. Lett., 2017;0(0):.
Species: Rat
Sample Type: Whole Tissue
Application: IHC - Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury.
Authors: Miyoshi K, Obata K, Kondo T, Okamura H, Noguchi K
J. Neurosci., 2008;28(48):12775-87.
Species: Rat
Sample Type: In Vivo
Application: In vivo - Inhibition of angiogenesis by interleukin-4 gene therapy in rat adjuvant-induced arthritis.
Authors: Haas CS, Amin MA, Allen BB, Ruth JH, Haines GK, Woods JM, Koch AE
Arthritis Rheum., 2006;54(8):2402-14.
Species: Rat
Sample Type: Tissue Homogenates
Application: Neut - Caspase-1-processed interleukins in hyperoxia-induced cell death in the developing brain.
Authors: Felderhoff-Mueser U, Sifringer M, Polley O, Dzietko M, Leineweber B, Mahler L, Baier M, Bittigau P, Obladen M, Ikonomidou C, Buhrer C
Ann. Neurol., 2005;57(1):50-9.
Species: Rat
Sample Type: Tissue Homogenates
Application: WB - Role of IL-18 in acute lung inflammation.
Authors: Jordan JA, Guo RF, Yun EC, Sarma V, Warner RL, Crouch LD, Senaldi G, Ulich TR, Ward PA
J. Immunol., 2001;167(12):7060-8.
Species: Rat
Sample Type: BALF
Application: ELISA Development
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