抗CTLA-4抗体(Anti-CTLA-4, Mouse, Goat-Poly antibody)
掲載日情報：2021/01/28 現在Webページ番号：27040
CTLA-4に対する抗体(Anti-CTLA-4, Mouse, Goat-Poly )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2024年05月04日 00時00分現在]
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Anti-CTLA-4, Mouse, Goat-Poly |
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Anti-Mouse CTLA-4 Affinity Purified Polyclonal Ab |
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[在庫・価格 ：2024年05月04日 00時00分現在]
Anti-CTLA-4, Mouse, Goat-Poly
文献数： 2
- 商品コード：AF476
- メーカー：RSD
- 包装：100μg
- 価格：¥100,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
マッチドペア：Mouse CTLA-4 サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAF476，スタンダードとして#434-CT-200を用いる。 別名：CD Genbank No： 1493 Protein Accession No： Q6GTR6 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | Mouse | 免疫動物 | Goat | ||||
| 交差性 | Mouse | 適用 | ELISA,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Polyclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | |||||||
| 関連記事 |
R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Mouse CTLA-4 Affinity Purified Polyclonal Ab
文献数： 0
- 商品コード：AF476-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
※受注発注品。形状：溶液または凍結乾燥 別名：CD Genbank No： 1493 Protein Accession No： Q6GTR6 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | 法規備考 | ||||||
| 抗原種 | 免疫動物 | Goat | |||||
| 交差性 | Mouse | 適用 | ELISA,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Polyclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | |||||||
| 関連記事 |
R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Mouse |
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| Label | Unconjugated |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse CTLA-4Ala37-Phe162Accession # Q6GTR6 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects mouse CTLA-4 in ELISAs and Western blots. In sandwich immunoassays, less than 1% cross-reactivity with recombinant human CTLA‑4, recombinant mouse (rm) CD28, rmICOS, and rmPD-1 is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Mouse CTLA‑4 Fc Chimera (Catalog # 434-CT) |
| Mouse CTLA-4 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 0.2-0.8 µg/mL | Mouse CTLA‑4 Antibody (Catalog #AF476 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse CTLA‑4 Biotinylated Antibody (Catalog #BAF476 ) |
| ELISA Standard | Recombinant Mouse CTLA-4 Fc Chimera Protein (Catalog #434-CT ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: CTLA-4 | CTLA-4 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. CTLA-4 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CTLA-4 and CD28 are composed of a single |
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References
| Lenschow, D.J. et al. (1996) Annu. Rev. Immunol. 14:233. | |
| Hathcock, K.S. and R.J. Hodes (1996) Advances in Immunol. 62:131. | |
| Ward, S.G. (1996) Biochem. J. 318:361. | |
| Long Name: | Cytotoxic T-lymphocyte-associated Molecule 4 |
| Entrez Gene IDs: | 1493 (Human); 12477 (Mouse); 403696 (Canine); 102115124 (Cynomolgus Monkey) |
| Alternate Names: | CD; CD152 antigen; CD152; CD152IDDM12; CD28; celiac disease 3; CELIAC3; CTLA4; CTLA-4; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte-associated serine esterase-4; GRD4; GSE; ICOS; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 |
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Related Research Areas
| B Cell Activation | ||
| Co-stimulatory and Co-inhibitory Molecules | ||
| Dendritic Cell Co-stimulatory Molecules | ||
| ITIM/ITAM Immunoreceptors and Related Molecules | ||
| Regulatory T Cells (Tregs) | ||
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Related Product & Information
| Long Name | Cytotoxic T-lymphocyte-associated Molecule 4 |
|---|---|
| Entrez Gene IDs | 1493 (Human); 12477 (Mouse); 403696 (Canine); 102115124 (Cynomolgus Monkey) |
| Background | CTLA-4 |
| background_content | Background: CTLA-4 CTLA-4 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. CTLA-4 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CTLA-4 and CD28 are composed of a singleIg V‑like extracellular domain, a transmembrane domain and an intracellular domain. CTLA-4 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. The genes encoding these two molecules are closely linked on human chromosome 2. CTLA-4 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CTLA-4 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CTLA-4 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with 20-100-fold higher affinity than CD28. The physiological role of CTLA-4 in T cell costimulation is currently being studied. |
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Citations
- Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig.
Authors: Bonham CA, Peng L, Liang X, Chen Z, Wang L, Ma L, Hackstein H, Robbins PD, Thomson AW, Fung JJ, Qian S, Lu L
J. Immunol., 2002;169(6):3382-91.
Species: Mouse
Sample Type: Serum
Application: ELISA Development
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