抗IL-6 R alpha抗体(Anti-IL-6 Receptor, Soluble, Human, Goat-Poly antibody)

掲載日情報:2019/10/21 現在Webページ番号:26837

IL-6 R alphaに対する抗体(Anti-IL-6 Receptor, Soluble, Human, Goat-Poly )です。
本製品は研究用です。研究用以外には使用できません。

価格

[在庫・価格 :2025年04月26日 20時35分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
詳細 商品名
  • 商品コード
  • メーカー
  • 包装
  • 価格
  • 在庫
  • 法規制等
納期 文献数
Anti-IL-6 Receptor α, Human, Goat-Poly
10日程度 ※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 1
  • 使用文献
  • メーカーサイト
  • お問い合わせ
説明文
別名:IL-6 R,IL-6Ra,IL6R,IL-6R alpha,IL-6R α
Genbank No: 3570
Protein Accession No: P08887
法規制等
保存条件 -20℃ 法規備考
抗原種 Human 免疫動物 Goat クラス IgG 標識 Unlabeled
交差性 Human 適用 Neutralising,Western Blot
クロナリティ Polyclonal フォーマット 性状 Protein A/G Affinity Purified 吸収処理
掲載カタログ

製品記事 Helper T Cells Marker Antibodies
関連記事

[在庫・価格 :2025年04月26日 20時35分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

Anti-IL-6 Receptor α, Human, Goat-Poly

文献数: 1

説明文 別名:IL-6 R,IL-6Ra,IL6R,IL-6R alpha,IL-6R α
Genbank No: 3570
Protein Accession No: P08887
法規制等
保存条件 -20℃ 法規備考
抗原種 Human 免疫動物 Goat
交差性 Human 適用 Neutralising,Western Blot
標識 Unlabeled 性状 Protein A/G Affinity Purified
吸収処理 クラス IgG
クロナリティ Polyclonal フォーマット
掲載カタログ

製品記事 Helper T Cells Marker Antibodies
関連記事



目次に戻る

Product Details

Species ReactivityHuman
LabelUnconjugated
ImmunogenS. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL‑6 R alpha Leu20-Asp358Accession # P08887
SourcePolyclonal Goat IgG
PurificationProtein A or G purified
SpecificityDetects human IL‑6 R alpha in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant mouse IL-6 R alpha and recombinant human LIF is observed.


目次に戻る

Applications and Data

 Recommended
Concentration
Sample
Western Blot1 µg/mLRecombinant Human IL‑6 R alpha (Catalog # 227-SR)
NeutralizationMeasured by its ability to neutralize IL‑6 R alpha -mediated inhibition of proliferation in the M1 mouse myeloid leukemia cell line. The Neutralization Dose (ND50) is typically 1-4 µg/mL in the presence of 30 ng/mL Recombinant Human IL‑6 R alpha and 30 ng/mL Recombinant Human IL‑6.


Neutralization
IL‑6 R alpha  Enhancement of IL‑6‑dependent Inhibition of Cell Proliferation and Neutralization by Human IL‑6 R alpha  Antibody.
Recombinant Human IL‑6 R alpha (Catalog # 227-SR) enhances Recombinant Human IL‑6 (Catalog # 206-IL) inhibition of proliferation in the M1 mouse myeloid leukemia cell line in a dose-dependent manner (orange line). Enhancement of Recombinant Human IL‑6 (30 ng/mL) activity elicited by Recombinant Human IL‑6 R alpha (30 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL‑6 R alpha Polyclonal Antibody (Catalog #AB‑227‑NA). The ND50 is typically 1‑4 µg/mL.


目次に戻る

Related Product & Information

Long NameInterleukin 6 Receptor alpha
Entrez Gene IDs3570 (Human); 16194 (Mouse)
BackgroundIL-6 R alpha
background_contentBackground:
IL-6 R alpha
The multi-functional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6 R alpha ) and a signal-transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. Both components of the receptor complex, IL-6 R alpha and gp130 have been cloned, sequenced, and expressed (1-4). A soluble form of the IL-6 R alpha has been found in the urine of healthy adult humans (5). This soluble receptor apparently arises from proteolytic cleavage of membrane-bound IL-6 R alpha and is about 50kDa in size. No naturally-occurring mRNA encoding a truncated form of the IL-6 R alpha has been reported. Soluble forms of human and murine IL-6 R alpha s have been constructed, however, by insertion of termination codons into the regions of the IL-6 R alpha cDNAs encoding the external portions of the receptors and prior to the transmembrane domains. These soluble receptors have been expressed in COS-7 and CHO cells and have been shown to bind to IL-6 in solution and to augment the activity of IL-6 as a result of the binding of the IL-6/IL-6 R alpha complex to membrane-bound gp130 (6, 7).


目次に戻る

Citations

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
  1. Lipopolysaccharide-squamous cell carcinoma-monocyte interactions induce cancer-supporting factors leading to rapid STAT3 activation.
    Authors: Kurago ZB, Lam-ubol A, Stetsenko A
    Head Neck Pathol, 2008;2(1):1-12.
    Species: Human
    Sample Type: Whole Cells
    Application: Neut



目次に戻る

お問い合わせ先

(テクニカルサポート 試薬担当)

reagent@funakoshi.co.jp

製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。
表示価格に、消費税等は含まれていません。一部価格が予告なく変更される場合がありますので、あらかじめご了承下さい。