抗Lymphotoxin-alpha/TNF-beta抗体(Anti-TNF-β, Human, Goat-Poly antibody)
掲載日情報：2019/10/21 現在Webページ番号：26822
Lymphotoxin-alpha/TNF-betaに対する抗体(Anti-TNF-β, Human, Goat-Poly )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2026年04月06日 20時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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[在庫・価格 ：2026年04月06日 20時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-TNF-β, Human, Goat-Poly
文献数： 0
- 商品コード：AB-211-NA
- メーカー：RSD
- 包装：1mg
- 価格：¥72,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 別名：LT Genbank No： 4049 Protein Accession No： P01374 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Human | 免疫動物 | Goat |
| 交差性 | Human | 適用 | Neutralising,Western Blot |
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | Helper T Cells Marker Antibodies |
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| 関連記事 | |||
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Product Details
| Species Reactivity | Human |
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| Label | Unconjugated |
| Immunogen | E. coli-derived recombinant human Lymphotoxin‑ alpha /TNF‑ beta Leu35-Leu205Accession # P01374 |
| Source | Polyclonal Goat IgG |
| Purification | Protein A or G purified |
| Specificity | Detects human Lymphotoxin‑ alpha /TNF‑ beta in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human TNF-alpha and recombinant mouse TNF-alpha is observed. Neutralizes the biological activity of recombinant human (rh) TNF-beta and natural human TNF-beta, but will not neutralize the biological activity of rhTNF-alpha or recombinant mouse TNF-alpha. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 1 µg/mL | Recombinant Human Lymphotoxin‑ alpha /TNF‑ beta (Catalog # 211-TB) |
| Neutralization | Measured by its ability to neutralize Lymphotoxin‑ alpha /TNF‑ beta -induced cytotoxicity in the L‑929 mouse fibroblast cell line. Matthews, N. and M. L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M. J. et al. (eds): IRL Press. 221. The Neutralization Dose (ND50) is typically 0.2-0.4 µg/mL in the presence of 1 ng/mL Recombinant Human Lymphotoxin‑ alpha /TNF‑ beta and 1 µg/mL actinomycin D. | |
| Neutralization | |
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 | Cytotoxicity Induced by Lymphotoxin‑ alpha /TNF‑ beta and Neutralization by Human Lymphotoxin‑ alpha /TNF‑ beta Antibody. Recombinant Human Lymphotoxin‑ alpha /TNF‑ beta (Catalog # 211‑TB) induces cytotoxicity in the the L‑929 mouse fibroblast cell line in a dose-dependent manner (orange line), as measured by crystal violet staining. Cytotoxicity elicited by Recombinant Human Lymphotoxin‑ alpha /TNF‑ beta (1 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti‑Human Lymphotoxin‑ alpha /TNF‑ beta Polyclonal Antibody (Catalog # AB‑211‑NA). The ND50 is typically 0.2‑0.4 µg/mL in the presence of the metabolic inhibitor actinomycin D (1 µg/mL). |
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Related Product & Information
| Long Name | Tumor Necrosis Factor beta |
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| Entrez Gene IDs | 4049 (Human); 16992 (Mouse) |
| Background | Lymphotoxin-alpha/TNF-beta |
| background_content | Background: Lymphotoxin-alpha/TNF-beta Tumor necrosis factor beta (TNF-beta ), also known as lymphotoxin-alpha (LT-alpha ), and TNF-alpha, are two structurally and functionally related proteins that bind to the same cell surface receptors (TNF RI and TNF RII) and produce a vast range of similar, but not identical, effects. Among these effects is the ability to kill certain tumor cells directly, from which the names tumor necrosis factor and lymphotoxin both derive. Mature TNF-beta /LT-alpha and TNF-alpha share approximately 35% protein sequence homology and the biologically active secreted forms of both proteins are homotrimers. Whereas TNF-alpha can exist as a type II membrane protein, TNF-beta /LT-alpha possesses a typical signal peptide sequence and is a secreted protein. It has been shown that TNF-beta /LT-alpha is also present on the cell surface of activated T, B, and LAK cells as a heteromeric complex with LT-beta, a type II membrane protein that is another member of the TNF ligand family. The genes for TNF-alpha, TNF-beta /LT-alpha, and LT-beta are closely linked within the major histocompatibility complex. TNF-beta /LT-alpha is expressed in activated T- and B-lymphocytes. In addition to its cytotoxic action on tumor cells, TNF-beta /LT-alpha has been shown to be a mediator of inflammation and immune function. Evidence is also accumulating that TNF-beta /LT-alpha and TNF-alpha are mediators in the pathogenesis of certain autoimmune diseases. TNF-beta /LT-alpha has also been shown to have a role in lymphoid organ development. Human and mouse TNF-beta /LT-alpha share approximately 74% homology in their amino acid sequence and exhibit cross-species activity. |
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