抗PINK1モノクローナル抗体(Anti-PINK1) PINK1 antibody (S4-15:クローン名) | StressMarq Biosciences
掲載日情報：2017/10/30 現在Webページ番号：26688
PINK1に対するモノクローナル抗体 (Anti-PINK1) PINK1 antibody (S4-15:クローン名) です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月28日 16時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-PINK1, Mouse-Mono(S4-15) |
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[在庫・価格 ：2025年04月28日 16時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-PINK1, Mouse-Mono(S4-15)
文献数： 1
- 商品コード：SMC-450D
- メーカー：STQ
- 包装：100μg
- 価格：¥82,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 別名：Parkinson disease (autosomal recessive) 6，EC 2.7.11.1，PARK6，serine/threonine-protein kinase PINK1 mitochondrial，PTEN-induced putative kinase protein 1，protein kinase BRPK，BRPK，FLJ27236，PTEN induced putative kinase 1，Phosphatase and Tensin Homolog クローン：N4/15 (Formerly sold as S4-15) Genbank No： 65018 Gene Accession No： NP_115785.1 Protein Accession No： Q9BXM7.1 |
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| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Human | 免疫動物 | Mouse |
| 交差性 | Human/Rat/Mouse | 適用 | IC,IF,IHC,Western Blot |
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Monoclonal | フォーマット | |
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| 製品記事 | 抗PINK1抗体 | Anti-PINK1 antibody 抗PINK1抗体 神経科学（Neuroscience）研究用 抗体／タンパク質 （StressMarq Biosciences社） |
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製品情報
Product Name
PINK1 Antibody
Type
Monoclonal
Datasheet
Description
Anti-PINK1
Research Area
Neuroscience
Alternative Names
Parkinson disease (autosomal recessive) 6, EC 2.7.11.1, PARK6, serine/threonine-protein kinase PINK1 mitochondrial, PTEN-induced putative kinase protein 1, protein kinase BRPK, BRPK, FLJ27236, PTEN induced putative kinase 1, Phosphatase and Tensin Homolog
Clone Number
S4-15
Host Species
Mouse
Isotype
IgG1
Immunogen
Fusion protein amino acids 112-496 (cytoplasmic C-terminus) of human PINK1 (accession # Q9BZM7). 82% identical to rat and 81% identical to mouse. >30% identity with DMPK.
Applications
WB, ICC, IHC
Species Reactivity
Human, Rat, Mouse
Accession Number
NP_115785.1
Gene ID
65018
SwissProt
Q9BXM7.1
Background Info
Detects a 50 kDa protein corresponding to the molecular weight of PINK1
Recommended Dilutions
1:1000 WB
Form
Protein G Purified
Storage Buffer
PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Certificate of Analysis
References
Research Background
PINK1 (PTEN induced putative kinase 1) is a mitochondrial serine/threonine kinase which maintains mitochondrial function/integrity, provides protection against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins, and is involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). PINK1 is synthesized as a 63 kD protein which undergoes proteolyt processing to generate at least two cleaved forms (55 kD and 42 kD). PINK1 and its substrates have been found in the cytosol as well as in different sub-mitochondrial compartments, and according to the recent reports; PINK1 may be targeted to OMM (outer mitochondrial membrane) with its kinase domain facing the cytosol, providing a possible explanation for the observed physical interaction with the cytosolic E3 ubiquitin ligase Parkin. Defective PINK1 may cause alterations in processing, stability, localization and activity as well as binding to substrates/interaction-partners which ultimately leads to differential effects on mitochondrial function and morphology. Mutations in PINK1 are linked to autosomal recessive early onset Parkinson's disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of alpha-synuclein, as well as proteasome dysfunction.
PINK1 (PTEN induced putative kinase 1) is a mitochondrial serine/threonine kinase which maintains mitochondrial function/integrity, provides protection against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins, and is involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). PINK1 is synthesized as a 63 kD protein which undergoes proteolyt processing to generate at least two cleaved forms (55 kD and 42 kD). PINK1 and its substrates have been found in the cytosol as well as in different sub-mitochondrial compartments, and according to the recent reports; PINK1 may be targeted to OMM (outer mitochondrial membrane) with its kinase domain facing the cytosol, providing a possible explanation for the observed physical interaction with the cytosolic E3 ubiquitin ligase Parkin. Defective PINK1 may cause alterations in processing, stability, localization and activity as well as binding to substrates/interaction-partners which ultimately leads to differential effects on mitochondrial function and morphology. Mutations in PINK1 are linked to autosomal recessive early onset Parkinson's disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of alpha-synuclein, as well as proteasome dysfunction.
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