抗GABA(B) Receptor 2モノクローナル抗体(Anti-GABA(B) Receptor 2) GABA(B) Receptor 2 antibody (S81-2:クローン名) | StressMarq Biosciences
掲載日情報:2017/10/30 現在Webページ番号:26663
GABA(B) Receptor 2に対するモノクローナル抗体 (Anti-GABA(B) Receptor 2) GABA(B) Receptor 2 antibody (S81-2:クローン名) です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 :2025年04月26日 00時00分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-GABA(B)R2 Protein, Mouse-Mono(S81-2) |
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[在庫・価格 :2025年04月26日 00時00分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-GABA(B)R2 Protein, Mouse-Mono(S81-2)
文献数: 0
- 商品コード:SMC-402D
- メーカー:STQ
- 包装:100μg
- 価格:¥82,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 別名:BcDNA:GH07312,CG6706,CT20836,D GABA[[B]]R2,D Gaba2,FLJ36928,G protein coupled receptor 51,G-protein coupled receptor 51,GAB B R2,GABA B R2,GABA B receptor 2,GABA B RECEPTOR,GABA-B receptor 2,GABA-B-R2,GABA-BR2,GABA[[B]]R2,GABAB R2,GABABR 2,GABABR2,GABB R2 クローン:N81/2 (Formerly sold as S81-2) Genbank No: 83633 Gene Accession No: NP_113990.1 Protein Accession No: O88871 |
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保存条件 | 法規備考 | ||
抗原種 | Rat | 免疫動物 | Mouse |
交差性 | Human/Mouse/Rat | 適用 | IC,IF,IHC,Western Blot |
標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
吸収処理 | クラス | IgG | |
クロナリティ | Monoclonal | フォーマット | |
掲載カタログ |
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製品記事 | 抗GABA B Receptor 2抗体 | Anti-GABA B Receptor 2 antibody Anti-Neurotransmitter Receptor Antibody(StressMarq Biosciences社) 神経科学(Neuroscience)研究用 抗体/タンパク質 (StressMarq Biosciences社) |
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製品情報
Product Name
GABA(B) Receptor 2 Antibody
Type
Monoclonal
Datasheet
Description
Anti-GABA(B) Receptor 2
Research Area
Transporters
Alternative Names
BcDNA:GH07312, CG6706, CT20836, D GABA[[B]]R2, D Gaba2, FLJ36928, G protein coupled receptor 51, G-protein coupled receptor 51, GAB B R2, GABA B R2, GABA B receptor 2, GABA B RECEPTOR, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABA[[B]]R2, GABAB R2, GABABR
Clone Number
S81-2
Host Species
Mouse
Isotype
IgG1
Immunogen
Fusion protein amino acids 861-912 of rat GABA(B)R2
Applications
IHC, WB, ICC
Species Reactivity
Human, Mouse, Rat
Accession Number
NP_113990.1
Gene ID
83633
SwissProt
O88871
Background Info
Detects ~105kDa. No cross-reactivity against GABA(B)R1
Form
Protein G Purified
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide.
Certificate of Analysis
1µg/mL of SMC-402 was sufficient for detection of GABA(B)R2 in 20µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
References
Research Background
GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission (1). Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site (2). Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a
95 kD protein (3). G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation (1).
References
GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission (1). Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site (2). Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a
95 kD protein (3). G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation (1).
References
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