抗HCN3モノクローナル抗体(Anti-HCN3) HCN3 antibody (S141-28:クローン名) | StressMarq Biosciences

掲載日情報:2017/10/30 現在Webページ番号:26624

HCN3に対するモノクローナル抗体 (Anti-HCN3) HCN3 antibody (S141-28:クローン名) です。


本製品は研究用です。研究用以外には使用できません。

[在庫・価格 :2024年03月29日 17時15分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
詳細 商品名
  • 商品コード
  • メーカー
  • 包装
  • 価格
  • 在庫
  • 法規制等
納期 文献数
Anti-HCN3, Mouse-Mono(S141-28)
中止
本製品は取扱中止になりました 0
説明文
クローン:S141-28
Genbank No: 15168
Gene Accession No: NP_032253.1
Protein Accession No: O88705
法規制等
保存条件 法規備考
抗原種 Mouse 免疫動物 Mouse クラス IgG 標識 Unlabeled
交差性 Human/Mouse/Rat 適用 Antibody Microarray,IC,IF,IHC,Western Blot
クロナリティ Monoclonal フォーマット 性状 Protein A/G Affinity Purified 吸収処理
掲載カタログ

製品記事 抗HCN3抗体 | Anti-HCN3 antibody
抗イオンチャネル(Ion Channel)抗体
神経科学(Neuroscience)研究用 抗体/タンパク質 (StressMarq Biosciences社)
関連記事

[在庫・価格 :2024年03月29日 17時15分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

Anti-HCN3, Mouse-Mono(S141-28)

文献数: 0

  • 商品コード:SMC-306D
  • メーカー:STQ
  • 包装:100μg
  • 本製品は取扱中止になりました

説明文 クローン:S141-28
Genbank No: 15168
Gene Accession No: NP_032253.1
Protein Accession No: O88705
法規制等
保存条件 法規備考
抗原種 Mouse 免疫動物 Mouse
交差性 Human/Mouse/Rat 適用 Antibody Microarray,IC,IF,IHC,Western Blot
標識 Unlabeled 性状 Protein A/G Affinity Purified
吸収処理 クラス IgG
クロナリティ Monoclonal フォーマット
掲載カタログ

製品記事 抗HCN3抗体 | Anti-HCN3 antibody
抗イオンチャネル(Ion Channel)抗体
神経科学(Neuroscience)研究用 抗体/タンパク質 (StressMarq Biosciences社)
関連記事
中止

製品情報

Western blot analysis of HCN3 in rat brain membrane lysates using a 1:1000 dilution of SMC-306.
Western blot analysis of HCN3 in rat brain membrane lysates using a 1:1000 dilution of SMC-306.
IF analysis of HCN3 in human hippocampal tissues using SMC-306.Courtesy of Dr. Turksen, Ottawa Hospital Research Institute, Canada.
IF analysis of HCN3 in human hippocampal tissues using SMC-306.Courtesy of Dr. Turksen, Ottawa Hospital Research Institute, Canada.
Product Name
HCN3 Antibody
Type
Monoclonal
Description
Anti-HCN3
Research Area
Ion Channels, Neuroscience
Alternative Names
KIAA1535, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3, hyperpolarization activated cyclic nucleotide-gated potassium channel 3
Clone Number
S141-28
Host Species
Mouse
Isotype
IgG1
Immunogen
Fusion protein amino acids 660-779 (C terminus) of mouse HCN3, accession number O88705
Applications
WB, ICC, IHC, IF
Species Reactivity
Mouse, Rat
Accession Number
NP_032253.1
Gene ID
15168
SwissProt
O88705
Background Info
Detects ~90kDa. No cross-reactivity against other HCNs
Recommended Dilutions
1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)
Form
Protein G Purified
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Certificate of Analysis
1 µg/mL of SMC-306 was sufficient for detection of HCN3 in 10µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
References
Research Background
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1).  They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane.  Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium.  Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels.  There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics.  The first are voltage- gated ion channels which open and close in response to membrane potential.  These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role.  Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein.  The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels.  Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both the heart and brain (3).

References
1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.:Sunderland, MA USA.

2. www.iochannels.org

3. Zong X., et al. (2005) J Biol Chem. 280(40): 34224-34233

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