抗SAP102抗体 | Anti-SAP102 antibody
掲載日情報：2018/10/03 現在Webページ番号：251714
StressMarq Biosciences社の抗SAP102抗体(Anti-SAP102 antibody)です。
※本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2025年04月26日 00時00分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-SAP102, Mouse-Mono(S19-2) |
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[在庫・価格 ：2025年04月26日 00時00分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-SAP102, Mouse-Mono(S19-2)
文献数： 0
- 商品コード：SMC-134C
- メーカー：STQ
- 包装：25μg
- 本製品は取扱中止になりました
| 説明文 | クローン：S19-2 Genbank No： 58948 Gene Accession No： NP_113827.1 Protein Accession No： Q62936 |
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| 保存条件 | 法規備考 | ||
| 抗原種 | Rat | 免疫動物 | Mouse |
| 交差性 | Human/Mouse/Rat | 適用 | Antibody Microarray,IC,IF,IHC,IP,Western Blot |
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Monoclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | グリアマーカー（Glial Markers）／ニューロンマーカー（Neuron Markers）抗体 （StressMarq Biosciences社） 神経科学（Neuroscience）研究用 抗体／タンパク質 （StressMarq Biosciences社） |
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| 関連記事 | |||
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製品情報
 | Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SAP102 Monoclonal Antibody, Clone S19-2 (SMC-134). Tissue: Neuroblastoma cell line SK-N-BE. Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SAP102 Monoclonal Antibody (SMC-134) at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm . Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) SAP102 Antibody (D) Composite. |
 | Western Blot analysis of Rat brain lysates showing detection of SAP102 protein using Mouse Anti-SAP102 Monoclonal Antibody, Clone S19-2 (SMC-134). Load: 15 µg protein. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-SAP102 Monoclonal Antibody (SMC-134) at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. |
Product Name
SAP102 Antibody
Clonality
Monoclonal
Description
Mouse Anti-Rat SAP102 Monoclonal IgG1
Research Areas
Cell Markers, Cell Signaling, Neuron Markers, Neuroscience, Organelle Markers, Postsynaptic Markers
Alternative Names
DLG3 Antibody, MRX90 Antibody, NEDLG Antibody, XLMR Antibody, Disks large homolog 3 Antibody, PSD-95/SAP90-related protein 1 Antibody, Synapse-associated protein 102 Antibody, SAP-102 Antibody
Clone Number
S19-2
Host Species
Mouse
Isotype
IgG1
Immunogen
Fusion protein amino acids 1-120 of rat SAP102
Applications
WB, IHC, IP, ICC/IF, AM
Species Reactivity
Human, Mouse, Rat
Accession Number
NP_113827.1
Gene ID
58948
Swiss Prot
Q62936
Specificity
Detects ~105kDa. No cross-reactivity against PSD95, SAP97 or Chapsyn-110.
Purification
Protein G Purified
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Certificate of Analysis
1 µg/ml was sufficient for detection of Sap102 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.
References
Scientific Background
Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal (1, 2). SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homology 3 domain and a guanylate kinase domain (3). All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway (3, 4). SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains (3). In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.
References
1. Muller B.M., et al. (1996) Neuron 17: 255-265.
2. Lau L. F., et al. (1996) J. Biol. Chem. 271: 21622-21628.
3. Cuthbert P.C., et al. (2007) J Neuroscience 27:2673-2682.
4. Lau L.F., et al. (1996) J Biol Chem 274:5782-5790.
Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal (1, 2). SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homology 3 domain and a guanylate kinase domain (3). All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway (3, 4). SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains (3). In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.
References
1. Muller B.M., et al. (1996) Neuron 17: 255-265.
2. Lau L. F., et al. (1996) J. Biol. Chem. 271: 21622-21628.
3. Cuthbert P.C., et al. (2007) J Neuroscience 27:2673-2682.
4. Lau L.F., et al. (1996) J Biol Chem 274:5782-5790.
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