YLF-466D | CAS:1273323-67-3

• 価格
• 構造式
• 製品情報
• 製品詳細
• 文献

価格

目次に戻る

構造式

目次に戻る

製品情報

YLF-466D is an orally bioavailable activator of AMP-activated protein kinase (AMPK), an enzyme involved in regulation of cellular energy homeostasis. YLF-466D activates AMPK at a concentration of 150 µM in platelets. It inhibits platelet aggregation induced by thrombin, ADP, and collagen (IC₅₀s = 84, 55, and 87 µM, respectively) and inhibits aggregation of whole blood. YLF-466D leads to dose-dependent glucose uptake in L6 myotubes and, at a dose of 150 mg/kg, improves glucose tolerance in two mouse models of diabetes.

目次に戻る

製品詳細

name	YLF-466D
Formal Name	3-[[(3E)-3-[(4-chlorophenyl)phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-1-yl]methyl]-benzoic acid
CAS Number	1273323-67-3
Molecular Formula	C29H20ClNO3
Formula Weight	465.9
Purity	≥98%
Formulation	A crystalline solid
λmax	341 nm
SMILES	O=C1N(CC2=CC=CC(C(O)=O)=C2)C3=C(C=CC=C3)/C1=C(C4=CC=CC=C4)\C5=CC=C(Cl)C=C5
InChI Code	InChI=1S/C29H20ClNO3/c30-23-15-13-21(14-16-23)26(20-8-2-1-3-9-20)27-24-11-4-5-12-25(24)31(28(27)32)18-19-7-6-10-22(17-19)29(33)34/h1-17H,18H2,(H,33,34)/b27-26+
InChI Key	BPBOVHROVFJFAH-CYYJNZCTSA-N
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
Stability	≥ 2 years

目次に戻る

文献

1. Liu, Y., Park, J.-M., Oh, S.-J., et al. Antiplatelet effect of a newly developed AMP-activated protein kinase activator YLF-466D. Eur. J. Pharmacol. 760, 81-87 (2015).

2. Yu, L.-F., Lo, Y.-Y., Su, M.-B., et al. Development of novel alkene oxindole derivatives as orally efficacious AMP-activated protein kinase activators. ACS Med. Chem. Lett. 4(5), 475-480 (2013).

3. Li, Y.-Y., Yu, L.-F., Zhang, L.-N., et al. Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicol. Appl. Pharmacol. 273(2), 325-334 (2013).

目次に戻る